HitPredict

Interactor 1: SKP1 (P63208)
S-phase kinase-associated protein 1 (Cyclin-A/CDK2-associated protein p19) (p19A) (Organ of Corti protein 2) (OCP-2) (Organ of Corti protein II) (OCP-II) (RNA polymerase II elongation factor-like protein) (SIII) (Transcription elongation factor B polypeptide 1-like) (p19skp1)
Gene: SKP1

Interactor 2: FBW10 (Q5XX13)
F-box/WD repeat-containing protein 10 (F-box and WD-40 domain-containing protein 10) (Ubiquitin ligase-specificity factor)
Gene: FBXW10

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	36990424
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 163 Hs			1 1052
+	Sp
		953229 SKP1_SCHPO (1-163): 6.54e-73: 217: 56.36		POF1_SCHPO (276-719): 1.06e-99: 329: 21.53
+	Sc
		431143 SKP1_YEAST (2-163): 5.85e-65: 198: 42.19		CDC4_YEAST (275-702): 1.26e-88: 303: 20.08
+	Hs
		245588 SKP1_HUMAN (1-163): 1.62e-87: 254: 100.00		TBL1X_HUMAN (514-840): 6.11e-51: 191: 11.59
+	Mm
		1257397 SKP1_MOUSE (1-163): 8.88e-88: 255: 99.39		FBXW7_MOUSE (40-516): 4.22e-39: 158: 12.28
+	Hs
		929021 SKP1_HUMAN (1-163): 1.62e-87: 254: 100.00		FBXW7_HUMAN (40-516): 5.06e-39: 157: 12.28
+	Mm
		1112932 SKP1_MOUSE (1-163): 8.88e-88: 255: 99.39		FBW1A_MOUSE (29-448): 4.19e-35: 144: 10.44
+	Dm
		218244 O77430_DROME (1-163): 1.01e-79: 235: 76.69		O44382_DROME (534-766): 1.07e-41: 162: 16.01
+	Xl
		1174984 SKP1_XENLA (1-163): 1.62e-87: 254: 100.00		TRCB_XENLA (604-838): 8.25e-29: 124: 7.72
+	Hs
		929125 SKP1_HUMAN (1-163): 1.62e-87: 254: 100.00		FBW1A_HUMAN (604-838): 1.88e-28: 124: 7.34
+	Ce
		105479 SKR1_CAEEL (4-162): 2.25e-78: 232: 70.81		SEL10_CAEEL (608-835): 1.23e-29: 127: 7.42
+	Dm
		285042 O77430_DROME (1-163): 1.01e-79: 235: 76.69		FBXW7_DROME (160-476): 3.51e-26: 118: 11.27
+	Mm
		1131317 SKP1_MOUSE (1-163): 8.88e-88: 255: 99.39		FBW1B_MOUSE (602-752): 6.67e-17: 87.3: 12.58
+	Hs
		929110 SKP1_HUMAN (1-163): 1.62e-87: 254: 100.00		FBW1B_HUMAN (602-752): 1.09e-16: 86.5: 12.58
+	Dm
		285012 O77430_DROME (1-163): 1.01e-79: 235: 76.69		Q9VDE3_DROME (613-761): 7.93e-16: 83.8: 12.08
+	Dm
		1180601 Q7KJ69_DROME (1-163): 1.92e-74: 221: 67.49		Q9VDE3_DROME (613-761): 7.93e-16: 83.8: 12.08
+	Sp
		1000009 SKP1_SCHPO (1-163): 6.54e-73: 217: 56.36		POF11_SCHPO (583-753): 4.07e-15: 81.4: 10.35
+	Sc
		759309 SKP1_YEAST (2-163): 5.85e-65: 198: 42.19		MET30_YEAST (641-900): 2.08e-19: 95.7: 8.81
+	Sp
		144900 SKP1_SCHPO (1-163): 6.54e-73: 217: 56.36		POP2_SCHPO (451-610): 2.74e-10: 66.6: 28.05
+	Dm
		1363661 Q9VWC4_DROME (2-153): 3.67e-64: 195: 56.21		Q9VDE3_DROME (613-761): 7.93e-16: 83.8: 12.08
+	Ce
		105997 G5EDD8_CAEEL (4-162): 1.84e-65: 199: 60.25		LIN23_CAEEL (613-682): 7.77e-11: 68.3: 12.86