HitPredict

Interactor 1: TAU (P10636)
Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau)
Gene: MAPT

Interactor 2: OTUB1 (Q96FW1)
Ubiquitin thioesterase OTUB1 (EC 3.4.19.12) (Deubiquitinating enzyme OTUB1) (OTU domain-containing ubiquitin aldehyde-binding protein 1) (Otubain-1) (hOTU1) (Ubiquitin-specific-processing protease OTUB1)
Gene: OTUB1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.63	0.60	0.619

Property	Details
Experiments	28083634, 35063084
Identification Methods	enzymatic study, proximity labelling technology, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0006974 - DNA damage response
Homologous interactions	2

Homologous interactions

Color coding for hit scores

	1 758 Hs			1 271
+	Mm
		498068 TAU_MOUSE (1-758): 1.4e-69: 244: 70.17		OTUB1_MOUSE (1-271): 3.18e-150: 422: 99.63
+	Hs
		654029 MAP4_HUMAN (3-742): 6.73e-32: 135: 20.56		OTUB1_HUMAN (1-271): 3.25e-150: 422: 100.00