Interactor 1: KAP0 (P10644)
cAMP-dependent protein kinase type I-alpha regulatory subunit (Tissue-specific extinguisher 1) (TSE1)
Gene: PRKAR1A

Interactor 2: GSK3B (P49841)
Glycogen synthase kinase-3 beta (GSK-3 beta) (EC 2.7.11.26) (Serine/threonine-protein kinase GSK3B) (EC 2.7.11.1)
Gene: GSK3B

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score Annotation score Interaction score
0.80 1.00 0.896

The method score is based on:

Property Details
Experiments 29568061, 32707033, 23602568, unassigned1655
Identification Methods proximity labelling technology, affinity chromatography technology, pull down, tandem affinity purification
Interaction Type physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains Pkinase~cNMP_binding, Pkinase~RIIa
Common GO terms GO:0005737 - cytoplasm
GO:0005813 - centrosome
GO:0005829 - cytosol
GO:0010629 - negative regulation of gene expression
GO:0031625 - ubiquitin protein ligase binding
and 3 others

more...

Homologous interactions 6

Homologous interactions

Color coding for hit scores

1 381
Hs

1 420
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Sc

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Last updated: 15 Jul 2024