HitPredict

Interactor 1: BIP (P11021)
Endoplasmic reticulum chaperone BiP (EC 3.6.4.10) (78 kDa glucose-regulated protein) (GRP-78) (Binding-immunoglobulin protein) (BiP) (Heat shock protein 70 family protein 5) (HSP70 family protein 5) (Heat shock protein family A member 5) (Immunoglobulin heavy chain-binding protein)
Gene: HSPA5

Interactor 2: TMEDA (P49755)
Transmembrane emp24 domain-containing protein 10 (Protein TMED10) (21 kDa transmembrane-trafficking protein) (S31I125) (S31III125) (Tmp-21-I) (Transmembrane protein Tmp21) (p23) (p24 family protein delta-1) (p24delta1) (p24delta)
Gene: TMED10

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.54	0.60	0.571

Property	Details
Experiments	36042349, 35271311
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005783 - endoplasmic reticulum GO:0005789 - endoplasmic reticulum membrane GO:0005793 - endoplasmic reticulum-Golgi intermediate compartment GO:0005886 - plasma membrane GO:0016020 - membrane and 1 others more... GO:0042470 - melanosome
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 654 Hs			1 219
+	Hs
		503685 HSP7C_HUMAN (26-637): 0: 916: 66.02		TMEDA_HUMAN (1-219): 4.49e-84: 250: 100.00
+	Hs
		504682 HSP7C_HUMAN (26-637): 0: 916: 66.02		TMED9_HUMAN (8-218): 4.55e-80: 241: 29.96
+	Hs
		502499 BIP_HUMAN (19-654): 0: 914: 100.00		TMED9_HUMAN (8-218): 4.55e-80: 241: 29.96
+	Hs
		504114 HSP7C_HUMAN (26-637): 0: 916: 66.02		TMED2_HUMAN (30-218): 4.01e-67: 206: 20.53
+	Hs
		502128 BIP_HUMAN (19-654): 0: 914: 100.00		TMED2_HUMAN (30-218): 4.01e-67: 206: 20.53
+	Hs
		502708 BIP_HUMAN (19-654): 0: 914: 100.00		TMED5_HUMAN (24-216): 5.38e-56: 179: 17.16