Protein: ASXL3
Putative Polycomb group protein ASXL3 (Additional sex combs-like protein 3)

Gene: ASXL3
Organism: Homo sapiens
Interactions: 163
UniProt ID: Q9C0F0

Gene Ontology (top 5):
GO:0003677 - DNA binding
GO:0003682 - chromatin binding
GO:0008270 - zinc ion binding
GO:0009887 - animal organ morphogenesis
GO:0035517 - PR-DUB complex

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1364582

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

3

11

Small-scale

0.847

High

260423

BRD4
Bromodomain-containing protein 4

2

13

Small-scale

0.595

High

987469

RL40
Ubiquitin-ribosomal protein eL40 fusion protein

1

5

High-throughput

0.553

High

1149186

SF3A1
Splicing factor 3A subunit 1

1

16

High-throughput

0.553

High

542205

TOP1
DNA topoisomerase 1

1

1

High-throughput

0.515

High

909178

NEK4
Serine/threonine-protein kinase Nek4

1

7

High-throughput

0.489

High

143240

NFIB
Nuclear factor 1 B-type

1

10

High-throughput

0.479

High

186002

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

7

Small-scale

0.479

High

228361

CPSF5
Cleavage and polyadenylation specificity factor subunit 5

1

2

High-throughput

0.479

High

256982

H2B1K
Histone H2B type 1-K

1

20

High-throughput

0.479

High

259093

DNJA2
DnaJ homolog subfamily A member 2

1

16

High-throughput

0.479

High

334096

SMC2
Structural maintenance of chromosomes protein 2

1

7

High-throughput

0.479

High

390167

ALBU
Albumin

1

4

High-throughput

0.479

High

404398

GCR
Glucocorticoid receptor

1

20

High-throughput

0.479

High

424458

HMGN1
Non-histone chromosomal protein HMG-14

1

1

High-throughput

0.479

High

426572

HMGN2
Non-histone chromosomal protein HMG-17

1

5

High-throughput

0.479

High

443507

CDK1
Cyclin-dependent kinase 1

1

5

High-throughput

0.479

High

474268

NFIC
Nuclear factor 1 C-type

1

16

High-throughput

0.479

High

485396

ROA1
Heterogeneous nuclear ribonucleoprotein A1

1

13

High-throughput

0.479

High

535513

BIP
Endoplasmic reticulum chaperone BiP

1

16

High-throughput

0.479

High

552689

IMDH2
Inosine-5'-monophosphate dehydrogenase 2

1

4

High-throughput

0.479

High

558389

XRCC6
X-ray repair cross-complementing protein 6

1

8

High-throughput

0.479

High

573239

KPYM
Pyruvate kinase PKM

1

2

High-throughput

0.479

High

620574

NUCL
Nucleolin

1

13

High-throughput

0.479

High

648226

NDKB
Nucleoside diphosphate kinase B

1

5

High-throughput

0.479

High

658389

RS3
Small ribosomal subunit protein uS3

1

3

High-throughput

0.479

High

714961

EF1D
Elongation factor 1-delta

1

6

High-throughput

0.479

High

727954

DNJA1
DnaJ homolog subfamily A member 1

1

16

High-throughput

0.479

High

751340

DUT
Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial

1

2

High-throughput

0.479

High

794616

RBMX
RNA-binding motif protein, X chromosome

1

11

High-throughput

0.479

High

905480

HCFC1
Host cell factor 1

1

4

Small-scale

0.479

High

915485

HMGA2
High mobility group protein HMGI-C

1

4

High-throughput

0.479

High

958188

ARP3
Actin-related protein 3

1

15

High-throughput

0.479

High

980285

H4
Histone H4

1

8

High-throughput

0.479

High

981687

RAN
GTP-binding nuclear protein Ran

1

11

High-throughput

0.479

High

994783

YBOX1
Y-box-binding protein 1

1

6

High-throughput

0.479

High

1027735

HNRPU
Heterogeneous nuclear ribonucleoprotein U

1

14

High-throughput

0.479

High

1029748

FOXK2
Forkhead box protein K2

1

11

Small-scale

0.479

High

1087997

NFIA
Nuclear factor 1 A-type

1

17

High-throughput

0.479

High

1089541

ILF2
Interleukin enhancer-binding factor 2

1

4

High-throughput

0.479

High

1134372

IMB1
Importin subunit beta-1

1

9

High-throughput

0.479

High

1146810

PCBP1
Poly(rC)-binding protein 1

1

16

High-throughput

0.479

High

1148938

SC23A
Protein transport protein Sec23A

1

2

High-throughput

0.479

High

1157916

DDB1
DNA damage-binding protein 1

1

7

High-throughput

0.479

High

1162889

H2A2C
Histone H2A type 2-C

1

12

High-throughput

0.479

High

1338273

KMT2C
Histone-lysine N-methyltransferase 2C

1

20

Small-scale

0.479

High

1363319

DDX1
ATP-dependent RNA helicase DDX1

1

11

High-throughput

0.479

High

1387738

MBD6
Methyl-CpG-binding domain protein 6

1

16

High-throughput

0.479

High

1404894

PARK7
Parkinson disease protein 7

1

3

High-throughput

0.479

High

1405611

TSNAX
Translin-associated protein X

1

1

High-throughput

0.479

High

1421200

MBD5
Methyl-CpG-binding domain protein 5

1

6

High-throughput

0.479

High

1421203

DNPEP
Aspartyl aminopeptidase

1

2

High-throughput

0.479

High

1421205

RTRAF
RNA transcription, translation and transport factor protein

1

2

High-throughput

0.479

High

1421206

RUVB2
RuvB-like 2

1

9

High-throughput

0.479

High

889500

CLK1
Dual specificity protein kinase CLK1

1

19

High-throughput

0.457

High

179396

ARPC2
Actin-related protein 2/3 complex subunit 2

1

2

High-throughput

0.437

High

179560

ARPC3
Actin-related protein 2/3 complex subunit 3

1

1

High-throughput

0.437

High

194609

KDM6A
Lysine-specific demethylase 6A

1

9

Small-scale

0.437

High

209665

SERA
D-3-phosphoglycerate dehydrogenase

1

11

High-throughput

0.437

High

224356

BUB3
Mitotic checkpoint protein BUB3

1

14

High-throughput

0.437

High

281657

MTX2
Metaxin-2

1

2

High-throughput

0.437

High

283961

NDUS3
NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial

1

1

High-throughput

0.437

High

360216

GSHR
Glutathione reductase, mitochondrial

1

3

High-throughput

0.437

High

361919

HPRT
Hypoxanthine-guanine phosphoribosyltransferase

1

2

High-throughput

0.437

High

387327

APOA1
Apolipoprotein A-I

1

3

High-throughput

0.437

High

387559

APOA2
Apolipoprotein A-II

1

3

High-throughput

0.437

High

403220

APOB
Apolipoprotein B-100

1

2

High-throughput

0.437

High

407525

K2C1
Keratin, type II cytoskeletal 1

1

3

High-throughput

0.437

High

409072

G3P
Glyceraldehyde-3-phosphate dehydrogenase

1

3

High-throughput

0.437

High

425023

ADT2
ADP/ATP translocase 2

1

11

High-throughput

0.437

High

443960

ATPB
ATP synthase F(1) complex subunit beta, mitochondrial

1

12

High-throughput

0.437

High

445598

IF4E
Eukaryotic translation initiation factor 4E

1

4

High-throughput

0.437

High

446035

ENOA
Alpha-enolase

1

8

High-throughput

0.437

High

457680

TBB5
Tubulin beta chain

1

8

High-throughput

0.437

High

457990

TRY1
Serine protease 1

1

3

High-throughput

0.437

High

461907

HS90A
Heat shock protein HSP 90-alpha

1

13

High-throughput

0.437

High

468776

HS90B
Heat shock protein HSP 90-beta

1

13

High-throughput

0.437

High

501855

CO4A
Complement C4-A

1

5

High-throughput

0.437

High

521924

H14
Histone H1.4

1

19

High-throughput

0.437

High

532945

CH60
60 kDa heat shock protein, mitochondrial

1

7

High-throughput

0.437

High

566208

K1C10
Keratin, type I cytoskeletal 10

1

4

High-throughput

0.437

High

576829

SYDC
Aspartate--tRNA ligase, cytoplasmic

1

3

High-throughput

0.437

High

578717

GLNA
Glutamine synthetase

1

3

High-throughput

0.437

High

584802

NDKA
Nucleoside diphosphate kinase A

1

5

High-throughput

0.437

High

596336

H12
Histone H1.2

1

19

High-throughput

0.437

High

646932

PUR6
Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase

1

2

High-throughput

0.437

High

659834

SAHH
Adenosylhomocysteinase

1

1

High-throughput

0.437

High

680494

ATPA
ATP synthase F(1) complex subunit alpha, mitochondrial

1

12

High-throughput

0.437

High

701334

GSTM2
Glutathione S-transferase Mu 2

1

2

High-throughput

0.437

High

702688

NDUS1
NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial

1

2

High-throughput

0.437

High

716349

PRDX6
Peroxiredoxin-6

1

11

High-throughput

0.437

High

717984

2AAA
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform

1

7

High-throughput

0.437

High

724179

SDHA
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

1

3

High-throughput

0.437

High

732396

PRDX2
Peroxiredoxin-2

1

11

High-throughput

0.437

High

770283

RL22
Large ribosomal subunit protein eL22

1

2

High-throughput

0.437

High

771928

CBS
Cystathionine beta-synthase

1

2

High-throughput

0.437

High

772058

K1C9
Keratin, type I cytoskeletal 9

1

2

High-throughput

0.437

High

777555

K22E
Keratin, type II cytoskeletal 2 epidermal

1

6

High-throughput

0.437

High

801513

HSPA9
Stress-70 protein, mitochondrial

1

19

High-throughput

0.437

High

809832

RS19
Small ribosomal subunit protein eS19

1

5

High-throughput

0.437

High

829528

ECHA
Trifunctional enzyme subunit alpha, mitochondrial

1

5

High-throughput

0.437

High

852844

VDAC2
Non-selective voltage-gated ion channel VDAC2

1

9

High-throughput

0.437

High

860933

RS10
Small ribosomal subunit protein eS10

1

6

High-throughput

0.437

High

866815

CAZA2
F-actin-capping protein subunit alpha-2

1

7

High-throughput

0.437

High

881300

FAS
Fatty acid synthase

1

3

High-throughput

0.437

High

882145

TCPG
T-complex protein 1 subunit gamma

1

15

High-throughput

0.437

High

882872

EFTU
Elongation factor Tu, mitochondrial

1

14

High-throughput

0.437

High

891027

NDUV1
NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial

1

1

High-throughput

0.437

High

894589

GDIB
Rab GDP dissociation inhibitor beta

1

5

High-throughput

0.437

High

899219

TCPQ
T-complex protein 1 subunit theta

1

20

High-throughput

0.437

High

907573

UBP11
Ubiquitin carboxyl-terminal hydrolase 11

1

7

High-throughput

0.437

High

911094

IMA1
Importin subunit alpha-1

1

3

High-throughput

0.437

High

915179

CAZA1
F-actin-capping protein subunit alpha-1

1

7

High-throughput

0.437

High

942462

GSC
Homeobox protein goosecoid

1

8

High-throughput

0.437

High

948469

ARPC4
Actin-related protein 2/3 complex subunit 4

1

1

High-throughput

0.437

High

960554

PSME3
Proteasome activator complex subunit 3

1

2

High-throughput

0.437

High

965221

WDR5
WD repeat-containing protein 5

1

11

High-throughput

0.437

High

967551

RS7
Small ribosomal subunit protein eS7

1

3

High-throughput

0.437

High

972955

RS18
Small ribosomal subunit protein uS13

1

2

High-throughput

0.437

High

974468

SMD1
Small nuclear ribonucleoprotein Sm D1

1

5

High-throughput

0.437

High

974660

SMD2
Small nuclear ribonucleoprotein Sm D2

1

2

High-throughput

0.437

High

983048

RS25
Small ribosomal subunit protein eS25

1

1

High-throughput

0.437

High

990702

1433Z
14-3-3 protein zeta/delta

1

20

High-throughput

0.437

High

993322

ACTG
Actin, cytoplasmic 2

1

13

High-throughput

0.437

High

994363

PP2AA
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

1

9

High-throughput

0.437

High

996326

EF1A1
Elongation factor 1-alpha 1

1

11

High-throughput

0.437

High

996845

TBA1B
Tubulin alpha-1B chain

1

19

High-throughput

0.437

High

997499

TBB4B
Tubulin beta-4B chain

1

8

High-throughput

0.437

High

998004

CSK21
Casein kinase II subunit alpha

1

19

High-throughput

0.437

High

999610

HBG1
Hemoglobin subunit gamma-1

1

5

High-throughput

0.437

High

999679

HBA
Hemoglobin subunit alpha

1

5

High-throughput

0.437

High

1007261

TCPB
T-complex protein 1 subunit beta

1

18

High-throughput

0.437

High

1017483

FOXK1
Forkhead box protein K1

1

11

Small-scale

0.437

High

1057253

PRDX1
Peroxiredoxin-1

1

11

High-throughput

0.437

High

1058260

C1QBP
Complement component 1 Q subcomponent-binding protein, mitochondrial

1

4

High-throughput

0.437

High

1066480

RBBP4
Histone-binding protein RBBP4

1

9

High-throughput

0.437

High

1081650

HSP7E
Heat shock 70 kDa protein 14

1

13

High-throughput

0.437

High

1095223

MTAP
S-methyl-5'-thioadenosine phosphorylase

1

3

High-throughput

0.437

High

1146990

PCBP2
Poly(rC)-binding protein 2

1

15

High-throughput

0.437

High

1148040

SF3B3
Splicing factor 3B subunit 3

1

7

High-throughput

0.437

High

1156413

SEPT7
Septin-7

1

6

High-throughput

0.437

High

1162234

NDUA5
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5

1

2

High-throughput

0.437

High

1293411

CARM1
Histone-arginine methyltransferase CARM1

1

10

High-throughput

0.437

High

1307391

RIOX2
Ribosomal oxygenase 2

1

1

High-throughput

0.437

High

1371857

CUL5
Cullin-5

1

12

High-throughput

0.437

High

1382747

ISOC2
Isochorismatase domain-containing protein 2

1

4

High-throughput

0.437

High

1386121

ISOC1
Isochorismatase domain-containing protein 1

1

4

High-throughput

0.437

High

1406019

PHB2
Prohibitin-2

1

6

High-throughput

0.437

High

1406622

HCD2
3-hydroxyacyl-CoA dehydrogenase type-2

1

1

High-throughput

0.437

High

1407864

ANM1
Protein arginine N-methyltransferase 1

1

10

High-throughput

0.437

High

1411222

TIRR
Tudor-interacting repair regulator protein

1

2

High-throughput

0.437

High

1421195

SKI8
Superkiller complex protein 8

1

12

High-throughput

0.437

High

1421196

IPYR2
Inorganic pyrophosphatase 2, mitochondrial

1

1

High-throughput

0.437

High

1421197

VP37B
Vacuolar protein sorting-associated protein 37B

1

3

High-throughput

0.437

High

1421198

CYBP
Calcyclin-binding protein

1

3

High-throughput

0.437

High

1421199

RCC2
Protein RCC2

1

5

High-throughput

0.437

High

1421201

HOP2
Homologous-pairing protein 2 homolog

1

2

High-throughput

0.437

High

1421202

PFD2
Prefoldin subunit 2

1

2

High-throughput

0.437

High

1421204

MCTS1
Malignant T-cell-amplified sequence 1

1

1

High-throughput

0.437

High

1421207

RUVB1
RuvB-like 1

1

9

High-throughput

0.437

High

1421208

DRG1
Developmentally-regulated GTP-binding protein 1

1

4

High-throughput

0.437

High

1421209

RTCB
RNA-splicing ligase RtcB homolog

1

1

High-throughput

0.437

High

144483

SCD
Stearoyl-CoA desaturase

1

0

High-throughput

0.269

Low


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Last updated: 11Aug2025