HitPredict

Interactor 1: BIP (P11021)
Endoplasmic reticulum chaperone BiP (EC 3.6.4.10) (78 kDa glucose-regulated protein) (GRP-78) (Binding-immunoglobulin protein) (BiP) (Heat shock protein 70 family protein 5) (HSP70 family protein 5) (Heat shock protein family A member 5) (Immunoglobulin heavy chain-binding protein)
Gene: HSPA5

Interactor 2: NEK2 (P51955)
Serine/threonine-protein kinase Nek2 (EC 2.7.11.1) (HSPK 21) (Never in mitosis A-related kinase 2) (NimA-related protein kinase 2) (NimA-like protein kinase 1)
Gene: NEK2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	29863498
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005524 - ATP binding GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0030496 - midbody and 1 others more... GO:0032991 - protein-containing complex
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 654 Hs			1 445
+	Hs
		713928 HS71L_HUMAN (24-647): 0: 922: 63.16		NEK2_HUMAN (1-445): 5.46e-146: 425: 100.00
+	Hs
		503722 HSP7C_HUMAN (26-637): 0: 916: 66.02		NEK2_HUMAN (1-445): 5.46e-146: 425: 100.00
+	Hs
		871773 HSP72_HUMAN (25-636): 0: 905: 64.51		SIK2_HUMAN (2-396): 3.05e-111: 350: 25.47
+	Hs
		713953 HS71L_HUMAN (24-647): 0: 922: 63.16		STK4_HUMAN (6-442): 1.98e-108: 330: 22.75
+	Rn
		419264 BIP_RAT (1-654): 0: 918: 98.47		AAPK1_RAT (4-383): 1.2e-108: 333: 27.32
+	Hs
		504037 HSP7C_HUMAN (26-637): 0: 916: 66.02		KCC2D_HUMAN (6-391): 5.26e-110: 335: 23.01
+	Hs
		504002 HSP7C_HUMAN (26-637): 0: 916: 66.02		AAPK1_HUMAN (4-383): 1.46e-108: 333: 27.32
+	Rn
		871238 HSP7C_RAT (26-637): 0: 916: 66.02		AAPK1_RAT (4-383): 1.2e-108: 333: 27.32
+	Hs
		502041 BIP_HUMAN (19-654): 0: 914: 100.00		AAPK1_HUMAN (4-383): 1.46e-108: 333: 27.32
+	Hs
		503996 HSP7C_HUMAN (26-637): 0: 916: 66.02		STK4_HUMAN (6-442): 1.98e-108: 330: 22.75
+	Hs
		564065 HSP76_HUMAN (25-635): 0: 915: 62.54		STK4_HUMAN (6-442): 1.98e-108: 330: 22.75
+	Hs
		502036 BIP_HUMAN (19-654): 0: 914: 100.00		STK4_HUMAN (6-442): 1.98e-108: 330: 22.75
+	Rn
		483815 HS71B_RAT (26-635): 0: 910: 63.62		AAPK1_RAT (4-383): 1.2e-108: 333: 27.32
+	Hs
		871550 HSP72_HUMAN (25-636): 0: 905: 64.51		STK4_HUMAN (6-442): 1.98e-108: 330: 22.75
+	Hs
		714003 HS71L_HUMAN (24-647): 0: 922: 63.16		NEK8_HUMAN (6-270): 7.54e-54: 192: 40.23
+	Hs
		564110 HSP76_HUMAN (25-635): 0: 915: 62.54		NEK8_HUMAN (6-270): 7.54e-54: 192: 40.23
+	Hs
		713929 HS71L_HUMAN (24-647): 0: 922: 63.16		NEK4_HUMAN (8-271): 2.82e-49: 181: 40.91
+	Hs
		564042 HSP76_HUMAN (25-635): 0: 915: 62.54		NEK4_HUMAN (8-271): 2.82e-49: 181: 40.91
+	Hs
		851403 HSP72_HUMAN (25-636): 0: 905: 64.51		NEK4_HUMAN (8-271): 2.82e-49: 181: 40.91