HitPredict

Interactor 1: BIP (P11021)
Endoplasmic reticulum chaperone BiP (EC 3.6.4.10) (78 kDa glucose-regulated protein) (GRP-78) (Binding-immunoglobulin protein) (BiP) (Heat shock protein 70 family protein 5) (HSP70 family protein 5) (Heat shock protein family A member 5) (Immunoglobulin heavy chain-binding protein)
Gene: HSPA5

Interactor 2: SPDLY (Q96EA4)
Protein Spindly (hSpindly) (Arsenite-related gene 1 protein) (Coiled-coil domain-containing protein 99) (Rhabdomyosarcoma antigen MU-RMS-40.4A) (Spindle apparatus coiled-coil domain-containing protein 1)
Gene: SPDL1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	30258100
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol GO:0019899 - enzyme binding
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 654 Hs			1 605
+	Hs
		714046 HS71L_HUMAN (24-647): 0: 922: 63.16		SPDLY_HUMAN (1-605): 2.11e-78: 261: 100.00
+	Hs
		504558 HSP7C_HUMAN (26-637): 0: 916: 66.02		SPDLY_HUMAN (1-605): 2.11e-78: 261: 100.00
+	Hs
		564150 HSP76_HUMAN (25-635): 0: 915: 62.54		SPDLY_HUMAN (1-605): 2.11e-78: 261: 100.00
+	Hs
		503376 HSP7C_HUMAN (26-637): 0: 916: 66.02		DESP_HUMAN (15-507): 8.07e-47: 179: 14.37
+	Hs
		501641 BIP_HUMAN (19-654): 0: 914: 100.00		DESP_HUMAN (15-507): 8.07e-47: 179: 14.37
+	Hs
		254440 HSP7C_HUMAN (26-637): 0: 916: 66.02		ROCK2_HUMAN (2-601): 2.07e-45: 175: 18.70
+	Hs
		501880 BIP_HUMAN (19-654): 0: 914: 100.00		LAMB2_HUMAN (95-434): 1.66e-44: 173: 14.57
+	Hs
		504240 HSP7C_HUMAN (26-637): 0: 916: 66.02		MRCKG_HUMAN (79-496): 8.37e-36: 146: 17.24
+	Hs
		502210 BIP_HUMAN (19-654): 0: 914: 100.00		MRCKG_HUMAN (79-496): 8.37e-36: 146: 17.24
+	Hs
		501755 BIP_HUMAN (19-654): 0: 914: 100.00		MYH9_HUMAN (4-596): 3.84e-17: 87.9: 13.74
+	Hs
		501756 BIP_HUMAN (19-654): 0: 914: 100.00		MYH10_HUMAN (4-596): 7.47e-17: 87.1: 11.71
+	Hs
		502023 BIP_HUMAN (19-654): 0: 914: 100.00		CGNL1_HUMAN (80-605): 3.14e-13: 75.2: 13.85
+	Hs
		433114 BIP_HUMAN (19-654): 0: 914: 100.00		LAMB1_HUMAN (4-230): 1.14e-12: 73.6: 11.98
+	Hs
		504029 HSP7C_HUMAN (26-637): 0: 916: 66.02		ROCK1_HUMAN (18-586): 5.64e-11: 67.9: 10.33
+	Hs
		504493 HSP7C_HUMAN (26-637): 0: 916: 66.02		MY18A_HUMAN (36-569): 9.74e-11: 67.1: 14.03
+	Hs
		502805 HSP7C_HUMAN (26-637): 0: 916: 66.02		LAMC1_HUMAN (12-347): 5.01e-10: 64.8: 12.33
+	Hs
		504277 HSP7C_HUMAN (26-637): 0: 916: 66.02		WDR87_HUMAN (10-475): 1.57e-09: 63.2: 16.74
+	Hs
		501606 BIP_HUMAN (19-654): 0: 914: 100.00		LAMC1_HUMAN (12-347): 5.01e-10: 64.8: 12.33