HitPredict

Interactor 1: FGFR1 (P11362)
Fibroblast growth factor receptor 1 (FGFR-1) (EC 2.7.10.1) (Basic fibroblast growth factor receptor 1) (BFGFR) (bFGF-R-1) (Fms-like tyrosine kinase 2) (FLT-2) (N-sam) (Proto-oncogene c-Fgr) (CD antigen CD331)
Gene: FGFR1

Interactor 2: CRKL (P46109)
Crk-like protein
Gene: CRKL

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	19307307
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2, PK_Tyr_Ser-Thr~SH3_1
Common GO terms	GO:0001764 - neuron migration GO:0005829 - cytosol GO:0008284 - positive regulation of cell population proliferation GO:0008543 - fibroblast growth factor receptor signaling pathway GO:0016477 - cell migration
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 822 Hs			1 303
+	Mm
		555262 FGFR1_MOUSE (1-822): 0: 860: 98.42		CRKL_MOUSE (1-303): 2.79e-72: 227: 96.70
+	Hs
		507901 FGFR1_HUMAN (1-822): 0: 861: 100.00		CRK_HUMAN (3-302): 8.95e-54: 179: 55.21
+	Mm
		601624 FGFR2_MOUSE (1-821): 0: 768: 69.88		CRKL_MOUSE (1-303): 2.79e-72: 227: 96.70
+	Hs
		507843 FGFR1_HUMAN (1-822): 0: 861: 100.00		PLCG1_HUMAN (5-224): 1.42e-28: 117: 17.80
+	Hs
		507835 FGFR1_HUMAN (1-822): 0: 861: 100.00		PLCG2_HUMAN (5-188): 2.6e-27: 113: 19.10
+	Rn
		499160 FGFR1_RAT (1-822): 0: 849: 97.69		PLCG1_RAT (5-224): 2.46e-29: 119: 16.95
+	Hs
		508233 FGFR1_HUMAN (1-822): 0: 861: 100.00		ITSN2_HUMAN (74-298): 1.63e-17: 84.9: 16.44
+	Hs
		507832 FGFR1_HUMAN (1-822): 0: 861: 100.00		NCK1_HUMAN (85-196): 4.12e-16: 79.8: 22.81
+	Hs
		508140 FGFR1_HUMAN (1-822): 0: 861: 100.00		SH3K1_HUMAN (219-297): 1.64e-15: 78.7: 24.69
+	Hs
		507829 FGFR1_HUMAN (1-822): 0: 861: 100.00		VAV_HUMAN (214-293): 3.43e-15: 77.9: 30.86
+	Hs
		507939 FGFR1_HUMAN (1-822): 0: 861: 100.00		GRB2_HUMAN (240-295): 1.72e-10: 61.8: 26.32
+	Hs
		208983 FGFR1_HUMAN (1-822): 0: 861: 100.00		NCK2_HUMAN (72-204): 1.51e-09: 60.1: 21.48
+	Hs
		580923 FGFR2_HUMAN (1-821): 0: 803: 71.21		PLCG1_HUMAN (5-224): 1.42e-28: 117: 17.80
+	Hs
		601605 FGFR2_HUMAN (1-821): 0: 803: 71.21		ITSN2_HUMAN (74-298): 1.63e-17: 84.9: 16.44
+	Hs
		601492 FGFR2_HUMAN (1-821): 0: 803: 71.21		GRB2_HUMAN (240-295): 1.72e-10: 61.8: 26.32
+	Hs
		580927 FGFR3_HUMAN (6-821): 0: 730: 61.22		PLCG1_HUMAN (5-224): 1.42e-28: 117: 17.80
+	Hs
		609244 FGFR3_HUMAN (6-821): 0: 730: 61.22		GRB2_HUMAN (240-295): 1.72e-10: 61.8: 26.32
+	Hs
		580926 FGFR4_HUMAN (29-808): 0: 664: 55.60		PLCG1_HUMAN (5-224): 1.42e-28: 117: 17.80
+	Hs
		557606 FGFR4_HUMAN (29-808): 0: 664: 55.60		NCK1_HUMAN (85-196): 4.12e-16: 79.8: 22.81
+	Hs
		208993 FGFR4_HUMAN (29-808): 0: 664: 55.60		NCK2_HUMAN (72-204): 1.51e-09: 60.1: 21.48