HitPredict

Interactor 1: FGFR1 (P11362)
Fibroblast growth factor receptor 1 (FGFR-1) (EC 2.7.10.1) (Basic fibroblast growth factor receptor 1) (BFGFR) (bFGF-R-1) (Fms-like tyrosine kinase 2) (FLT-2) (N-sam) (Proto-oncogene c-Fgr) (CD antigen CD331)
Gene: FGFR1

Interactor 2: DYN2 (P50570)
Dynamin-2 (EC 3.6.5.5) (Dynamin 2) (Dynamin II)
Gene: DNM2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	35384245, 36736316
Identification Methods	proximity labelling technology, affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PH~PK_Tyr_Ser-Thr
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 822 Hs			1 870
+	Hs
		601480 FGFR2_HUMAN (1-821): 0: 803: 71.21		DYN2_HUMAN (1-870): 0: 1057: 100.00
+	Hs
		508270 FGFR1_HUMAN (1-822): 0: 861: 100.00		DYN3_HUMAN (1-870): 0: 994: 78.41
+	Hs
		601616 FGFR2_HUMAN (1-821): 0: 803: 71.21		DYN3_HUMAN (1-870): 0: 994: 78.41
+	Hs
		609215 FGFR3_HUMAN (6-821): 0: 730: 61.22		DYN2_HUMAN (1-870): 0: 1057: 100.00
+	Hs
		609615 FGFR3_HUMAN (6-821): 0: 730: 61.22		DYN3_HUMAN (1-870): 0: 994: 78.41
+	Hs
		607921 FGFR4_HUMAN (29-808): 0: 664: 55.60		DYN2_HUMAN (1-870): 0: 1057: 100.00
+	Hs
		608198 FGFR4_HUMAN (29-808): 0: 664: 55.60		DYN3_HUMAN (1-870): 0: 994: 78.41
+	Hs
		384503 NTRK1_HUMAN (122-769): 8.92e-140: 434: 25.96		DYN2_HUMAN (1-870): 0: 1057: 100.00
+	Hs
		384691 NTRK1_HUMAN (122-769): 8.92e-140: 434: 25.96		DYN1_HUMAN (1-846): 0: 1002: 79.04
+	Hs
		128396 NTRK1_HUMAN (122-769): 8.92e-140: 434: 25.96		DNM1L_HUMAN (6-743): 0: 787: 39.13
+	Hs
		572603 VGFR1_HUMAN (48-362): 8.54e-23: 107: 18.73		DYN2_HUMAN (1-870): 0: 1057: 100.00
+	Hs
		729628 VGFR2_HUMAN (43-343): 3.9e-15: 82.1: 16.26		DYN2_HUMAN (1-870): 0: 1057: 100.00