HitPredict

Interactor 1: FGFR1 (P11362)
Fibroblast growth factor receptor 1 (FGFR-1) (EC 2.7.10.1) (Basic fibroblast growth factor receptor 1) (BFGFR) (bFGF-R-1) (Fms-like tyrosine kinase 2) (FLT-2) (N-sam) (Proto-oncogene c-Fgr) (CD antigen CD331)
Gene: FGFR1

Interactor 2: MINK1 (Q8N4C8)
Misshapen-like kinase 1 (EC 2.7.11.1) (GCK family kinase MiNK) (MAPK/ERK kinase kinase kinase 6) (MEK kinase kinase 6) (MEKKK 6) (Misshapen/NIK-related kinase) (Mitogen-activated protein kinase kinase kinase kinase 6)
Gene: MINK1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	35384245
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	I-set~Pkinase, PK_Tyr_Ser-Thr~Pkinase
Common GO terms	GO:0000165 - MAPK cascade GO:0005524 - ATP binding GO:0005829 - cytosol GO:0006468 - protein phosphorylation GO:0046777 - protein autophosphorylation
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 822 Hs			1 1332
+	Hs
		508260 FGFR1_HUMAN (1-822): 0: 861: 100.00		TNIK_HUMAN (1-1332): 0: 1098: 60.83
+	Hs
		872460 EPHA5_HUMAN (3-791): 0: 639: 19.15		MINK1_HUMAN (1-1332): 0: 1277: 100.00
+	Hs
		1072547 EPHA7_HUMAN (3-783): 0: 629: 19.40		MINK1_HUMAN (1-1332): 0: 1277: 100.00
+	Hs
		324728 FGFR1_HUMAN (1-822): 0: 861: 100.00		M4K4_HUMAN (1-1332): 0: 1026: 57.14
+	Hs
		1083868 NTRK2_HUMAN (102-762): 5.62e-163: 495: 22.70		MINK1_HUMAN (1-1332): 0: 1277: 100.00
+	Hs
		1081533 NTRK3_HUMAN (163-762): 3.3e-161: 491: 25.08		MINK1_HUMAN (1-1332): 0: 1277: 100.00
+	Hs
		608181 FGFR4_HUMAN (29-808): 0: 664: 55.60		TNIK_HUMAN (1-1332): 0: 1098: 60.83
+	Hs
		665680 EPHB2_HUMAN (4-819): 0: 640: 18.07		TNIK_HUMAN (1-1332): 0: 1098: 60.83
+	Hs
		872502 EPHA5_HUMAN (3-791): 0: 639: 19.15		TNIK_HUMAN (1-1332): 0: 1098: 60.83
+	Hs
		1072625 EPHA7_HUMAN (3-783): 0: 629: 19.40		TNIK_HUMAN (1-1332): 0: 1098: 60.83
+	Hs
		324739 FGFR4_HUMAN (29-808): 0: 664: 55.60		M4K4_HUMAN (1-1332): 0: 1026: 57.14
+	Hs
		324742 EPHB2_HUMAN (4-819): 0: 640: 18.07		M4K4_HUMAN (1-1332): 0: 1026: 57.14
+	Hs
		324761 EPHA5_HUMAN (3-791): 0: 639: 19.15		M4K4_HUMAN (1-1332): 0: 1026: 57.14
+	Hs
		324809 EPHA7_HUMAN (3-783): 0: 629: 19.40		M4K4_HUMAN (1-1332): 0: 1026: 57.14
+	Hs
		324762 EPHA4_HUMAN (3-783): 0: 620: 19.44		M4K4_HUMAN (1-1332): 0: 1026: 57.14
+	Mm
		546291 NTRK2_MOUSE (111-762): 1.43e-163: 497: 23.74		TNIK_MOUSE (1-1332): 0: 1112: 62.60
+	Hs
		324810 NTRK3_HUMAN (163-762): 3.3e-161: 491: 25.08		M4K4_HUMAN (1-1332): 0: 1026: 57.14
+	Hs
		508290 FGFR1_HUMAN (1-822): 0: 861: 100.00		M4K5_HUMAN (5-307): 6.97e-71: 257: 45.60
+	Hs
		872510 EPHA5_HUMAN (3-791): 0: 639: 19.15		M4K5_HUMAN (5-307): 6.97e-71: 257: 45.60
+	Hs
		1072635 EPHA7_HUMAN (3-783): 0: 629: 19.40		M4K5_HUMAN (5-307): 6.97e-71: 257: 45.60