HitPredict

Interactor 1: TOP1 (P11387)
DNA topoisomerase 1 (EC 5.6.2.1) (DNA topoisomerase I)
Gene: TOP1

Interactor 2: BRD2 (P25440)
Bromodomain-containing protein 2 (O27.1.1)
Gene: BRD2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.64	0.60	0.624

Property	Details
Experiments	31753913, 30554943
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003682 - chromatin binding GO:0004674 - protein serine/threonine kinase activity GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 765 Hs			1 801
+	Hs
		508537 TOP1_HUMAN (1-765): 0: 932: 100.00		BRD3_HUMAN (53-764): 4.91e-124: 390: 56.56
+	Hs
		243847 TOP1_HUMAN (1-765): 0: 932: 100.00		BRD4_HUMAN (26-765): 9.66e-99: 336: 45.89
+	Rn
		1149818 TOP1_RAT (1-765): 0: 922: 96.48		Q6AYL3_RAT (323-598): 1.86e-35: 139: 24.28
+	Hs
		508728 TOP1_HUMAN (1-765): 0: 932: 100.00		BRD7_HUMAN (25-338): 4.42e-29: 125: 17.13
+	Hs
		508596 TOP1_HUMAN (1-765): 0: 932: 100.00		PB1_HUMAN (306-773): 2.79e-18: 92.6: 12.33
+	Hs
		1067060 THOC2_HUMAN (7-198): 3.62e-09: 62.4: 16.42		BRD3_HUMAN (53-764): 4.91e-124: 390: 56.56
+	Hs
		1067006 NIPBL_HUMAN (5-216): 7.71e-09: 61.7: 10.92		BRD3_HUMAN (53-764): 4.91e-124: 390: 56.56
+	Hs
		244681 THOC2_HUMAN (7-198): 3.62e-09: 62.4: 16.42		BRD4_HUMAN (26-765): 9.66e-99: 336: 45.89
+	Hs
		244571 NIPBL_HUMAN (5-216): 7.71e-09: 61.7: 10.92		BRD4_HUMAN (26-765): 9.66e-99: 336: 45.89
+	Hs
		1246372 THOC2_HUMAN (7-198): 3.62e-09: 62.4: 16.42		BRD7_HUMAN (25-338): 4.42e-29: 125: 17.13