Protein: NOD2
Nucleotide-binding oligomerization domain-containing protein 2 (Caspase recruitment domain-containing protein 15) (Inflammatory bowel disease protein 1)

Gene: NOD2
Organism: Homo sapiens
Interactions: 128
UniProt ID: Q9HC29

Gene Ontology (top 5):
GO:0001659 - temperature homeostasis
GO:0002221 - pattern recognition receptor signaling pathway
GO:0002250 - adaptive immune response
GO:0002606 - positive regulation of dendritic cell antigen processing and presentation
GO:0002720 - positive regulation of cytokine production involved in immune response

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

214464

RIPK2
Receptor-interacting serine/threonine-protein kinase 2

21

9

Small-scale

0.987

High

1401939

ERBIN
Erbin

5

13

Small-scale

0.925

High

1022794

XIAP
E3 ubiquitin-protein ligase XIAP

3

9

Small-scale

0.857

High

1438557

NOD2
Nucleotide-binding oligomerization domain-containing protein 2

3

18

Small-scale

0.821

High

712892

CASP1
Caspase-1

2

20

Small-scale

0.789

High

1438558

NLRC4
NLR family CARD domain-containing protein 4

2

20

Small-scale

0.776

High

1420415

NLRP1
NACHT, LRR and PYD domains-containing protein 1

2

16

Small-scale

0.770

High

1431505

CARD9
Caspase recruitment domain-containing protein 9

2

2

Small-scale

0.754

High

475000

VIME
Vimentin

4

11

Small-scale

0.708

High

1108171

SQSTM
Sequestosome-1

4

5

Small-scale

0.686

High

1389388

RNF31
E3 ubiquitin-protein ligase RNF31

4

3

Small-scale

0.686

High

214044

M3K7
Mitogen-activated protein kinase kinase kinase 7

3

5

Small-scale

0.678

High

1227491

A16L1
Autophagy-related protein 16-1

3

7

Small-scale

0.662

High

1418802

HOIL1
RanBP-type and C3HC4-type zinc finger-containing protein 1

3

3

Small-scale

0.656

High

1429982

SHRPN
Sharpin

3

2

Small-scale

0.656

High

1399392

NLRP3
NACHT, LRR and PYD domains-containing protein 3

1

17

Small-scale

0.653

High

50003

IRGM
Immunity-related GTPase family M protein

2

2

Small-scale

0.646

High

935154

TERA
Transitional endoplasmic reticulum ATPase

2

1

Small-scale

0.625

High

242987

PRKN
E3 ubiquitin-protein ligase parkin

1

9

Small-scale

0.618

High

885711

CASP4
Caspase-4

1

20

Small-scale

0.618

High

988726

RAC1
Ras-related C3 botulinum toxin substrate 1

1

3

Small-scale

0.618

High

1107228

BIRC3
Baculoviral IAP repeat-containing protein 3

1

9

Small-scale

0.618

High

1107486

BIRC2
Baculoviral IAP repeat-containing protein 2

1

9

Small-scale

0.618

High

1109669

RIPK1
Receptor-interacting serine/threonine-protein kinase 1

1

9

Small-scale

0.618

High

1158188

MK14
Mitogen-activated protein kinase 14

1

3

Small-scale

0.618

High

1250066

CASPC
Inactive caspase-12

1

20

Small-scale

0.618

High

1405245

M3K14
Mitogen-activated protein kinase kinase kinase 14

1

2

Small-scale

0.618

High

1438567

NOD1
Nucleotide-binding oligomerization domain-containing protein 1

1

17

Small-scale

0.618

High

1438568

CARD8
Caspase recruitment domain-containing protein 8

1

13

Small-scale

0.618

High

1315295

TRI22
E3 ubiquitin-protein ligase TRIM22

2

14

Small-scale

0.605

High

572225

TRI27
Zinc finger protein RFP

1

15

Small-scale

0.602

High

1438570

SGT1
Protein SGT1 homolog

2

13

Small-scale

0.601

High

1396047

SCYL1
N-terminal kinase-like protein

1

0

Small-scale

0.589

High

343813

LDOC1
Protein LDOC1

1

1

Small-scale

0.586

High

1357762

TRI41
E3 ubiquitin-protein ligase TRIM41

1

15

Small-scale

0.586

High

508663

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

4

Small-scale

0.575

High

618114

K1C15
Keratin, type I cytoskeletal 15

1

12

Small-scale

0.573

High

1047866

TLE1
Transducin-like enhancer protein 1

1

4

Small-scale

0.573

High

1420041

PP12C
Protein phosphatase 1 regulatory subunit 12C

1

4

Small-scale

0.573

High

1438562

CHMP5
Charged multivesicular body protein 5

1

1

Small-scale

0.573

High

1438575

P2R3B
Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta

1

1

Small-scale

0.573

High

1311409

ANKH1
Ankyrin repeat and KH domain-containing protein 1

1

0

Small-scale

0.561

High

1438559

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

2

0

Small-scale

0.559

High

1083154

GALT2
Polypeptide N-acetylgalactosaminyltransferase 2

1

0

Small-scale

0.549

High

1158085

2A5E
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform

1

0

Small-scale

0.549

High

1315189

CJ067
Uncharacterized protein C10orf67, mitochondrial

1

0

Small-scale

0.549

High

1371295

KAT5
Histone acetyltransferase KAT5

1

0

Small-scale

0.549

High

1438571

FIS1
Mitochondrial fission 1 protein

1

0

Small-scale

0.549

High

537935

HSP7C
Heat shock cognate 71 kDa protein

1

10

High-throughput

0.536

High

666772

MYL9
Myosin regulatory light polypeptide 9

1

2

High-throughput

0.536

High

727976

DNJA1
DnaJ homolog subfamily A member 1

1

7

High-throughput

0.536

High

880386

RL34
Large ribosomal subunit protein eL34

1

2

High-throughput

0.536

High

889007

TMEDA
Transmembrane emp24 domain-containing protein 10

1

7

High-throughput

0.536

High

961849

RL37A
Large ribosomal subunit protein eL43

1

2

High-throughput

0.536

High

1024468

S25A3
Solute carrier family 25 member 3

1

6

High-throughput

0.536

High

1085923

TWF1
Twinfilin-1

1

2

High-throughput

0.536

High

1105876

TMED1
Transmembrane emp24 domain-containing protein 1

1

9

High-throughput

0.536

High

1415421

TMED9
Transmembrane emp24 domain-containing protein 9

1

6

High-throughput

0.536

High

1438566

CHIP
E3 ubiquitin-protein ligase CHIP

1

5

High-throughput

0.536

High

1438572

HDGR3
Hepatoma-derived growth factor-related protein 3

1

1

High-throughput

0.536

High

1438574

SRPRB
Signal recognition particle receptor subunit beta

1

2

High-throughput

0.536

High

345116

RIGI
Antiviral innate immune response receptor RIG-I

1

9

Small-scale

0.515

High

1272569

CSN6
COP9 signalosome complex subunit 6

1

2

Small-scale

0.515

High

339595

ACSL3
Fatty acid CoA ligase Acsl3

1

0

High-throughput

0.513

High

483219

CLCA
Clathrin light chain A

1

0

High-throughput

0.513

High

610899

TCPA
T-complex protein 1 subunit alpha

1

0

High-throughput

0.513

High

718007

2AAA
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform

1

0

High-throughput

0.513

High

829553

ECHA
Trifunctional enzyme subunit alpha, mitochondrial

1

0

High-throughput

0.513

High

991103

2ABA
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform

1

0

High-throughput

0.513

High

1083530

BST2
Bone marrow stromal antigen 2

1

0

High-throughput

0.513

High

386253

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

15

Small-scale

0.508

High

1123825

DCTN1
Dynactin subunit 1

1

1

Small-scale

0.508

High

1132337

GOGB1
Golgin subfamily B member 1

1

1

Small-scale

0.508

High

1433080

CHM4B
Charged multivesicular body protein 4b

1

1

Small-scale

0.508

High

1438569

WBP11
WW domain-binding protein 11

1

1

Small-scale

0.508

High

1438563

NDUAD
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13

1

1

Small-scale

0.506

High

1258683

IKIP
Inhibitor of nuclear factor kappa-B kinase-interacting protein

1

1

Small-scale

0.504

High

715070

OAS2
2'-5'-oligoadenylate synthase 2

1

0

Small-scale

0.493

High

184921

SPTC1
Serine palmitoyltransferase 1

1

1

High-throughput

0.489

High

1308136

LUR1L
Leucine rich adaptor protein 1-like

1

0

Small-scale

0.486

High

447863

TPM3
Tropomyosin alpha-3 chain

1

2

Small-scale

0.481

High

456855

ANXA2
Annexin A2

1

3

Small-scale

0.481

High

482966

TPM1
Tropomyosin alpha-1 chain

1

2

Small-scale

0.481

High

488347

PPBI
Intestinal-type alkaline phosphatase

1

1

Small-scale

0.481

High

824370

RL13A
Large ribosomal subunit protein uL13

1

1

Small-scale

0.481

High

928228

HAP1
Huntingtin-associated protein 1

1

1

Small-scale

0.481

High

995481

TPM4
Tropomyosin alpha-4 chain

1

2

Small-scale

0.481

High

1138074

TNIP1
TNFAIP3-interacting protein 1

1

5

Small-scale

0.481

High

1393040

PDLI5
PDZ and LIM domain protein 5

1

2

Small-scale

0.481

High

1438576

TACC3
Transforming acidic coiled-coil-containing protein 3

1

4

Small-scale

0.481

High

485425

ROA1
Heterogeneous nuclear ribonucleoprotein A1

1

3

Small-scale

0.479

High

543543

VDR
Vitamin D3 receptor

1

5

Small-scale

0.479

High

639314

TNAP3
Tumor necrosis factor alpha-induced protein 3

1

3

Small-scale

0.479

High

761519

HS71L
Heat shock 70 kDa protein 1-like

1

10

Small-scale

0.479

High

852858

VDAC2
Non-selective voltage-gated ion channel VDAC2

1

2

High-throughput

0.479

High

939657

BID
BH3-interacting domain death agonist

1

1

Small-scale

0.479

High

992340

SKP1
S-phase kinase-associated protein 1

1

3

Small-scale

0.479

High

1045788

TF65
Transcription factor p65

1

1

Small-scale

0.479

High

1146640

TMED2
Transmembrane emp24 domain-containing protein 2

1

9

High-throughput

0.479

High

1214801

ATD3B
ATPase family AAA domain-containing protein 3B

1

9

Small-scale

0.479

High

1249441

OLFM4
Olfactomedin-4

1

3

Small-scale

0.479

High

1313847

S15A3
Solute carrier family 15 member 3

1

1

Small-scale

0.479

High

1329197

S15A4
Solute carrier family 15 member 4

1

1

Small-scale

0.479

High

1403583

MMS19
MMS19 nucleotide excision repair protein homolog

1

2

Small-scale

0.479

High

1414782

TRAF4
TNF receptor-associated factor 4

1

11

Small-scale

0.479

High

1420721

ZDHC5
Palmitoyltransferase ZDHHC5

1

1

Small-scale

0.479

High

1438561

ATD3A
ATPase family AAA domain-containing protein 3A

1

7

Small-scale

0.479

High

1438564

HSPB8
Heat shock protein beta-8

1

3

Small-scale

0.479

High

1438573

TRAF6
TNF receptor-associated factor 6

1

20

Small-scale

0.479

High

1438577

NEMO
NF-kappa-B essential modulator

1

4

Small-scale

0.479

High

1138215

ACAP1
Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1

1

1

Small-scale

0.462

High

1116782

AAMP
Angio-associated migratory cell protein

1

0

Small-scale

0.458

High

1438560

DUOX2
Dual oxidase 2

1

0

Small-scale

0.458

High

1438565

SPAT2
Spermatogenesis-associated protein 2

1

0

High-throughput

0.458

High

1294331

TRI50
E3 ubiquitin-protein ligase TRIM50

1

14

Small-scale

0.457

High

1420184

TRIM8
E3 ubiquitin-protein ligase TRIM8

1

18

Small-scale

0.457

High

85183

B7Z6G4
cDNA FLJ53193, highly similar to Homo sapiens caldesmon 1

1

3

High-throughput

0.445

High

95887

E7EQ72
Transmembrane p24 trafficking protein 2

1

9

High-throughput

0.445

High

472251

MYL3
Myosin light chain 3

1

2

High-throughput

0.445

High

1206322

Q5JSD2
Non-selective voltage-gated ion channel VDAC2

1

2

High-throughput

0.445

High

697665

PYR1
Multifunctional protein CAD

1

0

Small-scale

0.426

High

1398716

AP4AT
AP-4 complex accessory subunit Tepsin

1

0

Small-scale

0.426

High

1385696

ENTR1
Endosome-associated-trafficking regulator 1

1

0

Small-scale

0.305

High

1398844

DOCK7
Dedicator of cytokinesis protein 7

1

0

Small-scale

0.299

High

1201182

LARGN
Protein Largen

1

0

Small-scale

0.288

High

1405932

CCL13
C-C motif chemokine 13

1

0

Small-scale

0.251

Low

1331286

NAT16
Probable N-acetyltransferase 16

1

0

Small-scale

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025