HitPredict

Interactor 1: TOP1 (P11387)
DNA topoisomerase 1 (EC 5.6.2.1) (DNA topoisomerase I)
Gene: TOP1

Interactor 2: WDR82 (Q6UXN9)
WD repeat-containing protein 82
Gene: WDR82

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	24981860, 35271311
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003682 - chromatin binding GO:0005654 - nucleoplasm GO:0005730 - nucleolus
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1 765 Hs			1 313
+	Hs
		508647 TOP1_HUMAN (1-765): 0: 932: 100.00		FBXW7_HUMAN (93-312): 2.41e-53: 187: 17.49
+	Hs
		196949 TOP1_HUMAN (1-765): 0: 932: 100.00		PRP4_HUMAN (107-313): 1.92e-47: 168: 16.13
+	Hs
		508656 TOP1_HUMAN (1-765): 0: 932: 100.00		SNR40_HUMAN (135-313): 6.85e-40: 144: 13.89
+	Hs
		508566 TOP1_HUMAN (1-765): 0: 932: 100.00		A16L1_HUMAN (16-292): 3.04e-14: 75.1: 21.71
+	Mm
		981024 TOP1_MOUSE (1-765): 0: 921: 96.48		A16L1_MOUSE (16-292): 1.33e-13: 73.2: 22.78