HitPredict

Interactor 1: TOP2A (P11388)
DNA topoisomerase 2-alpha (EC 5.6.2.2) (DNA topoisomerase II, alpha isozyme)
Gene: TOP2A

Interactor 2: G3BP2 (Q9UN86)
Ras GTPase-activating protein-binding protein 2 (G3BP-2) (GAP SH3 domain-binding protein 2)
Gene: G3BP2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.60	0.628

Property	Details
Experiments	35271311, 34901782
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003723 - RNA binding GO:0005737 - cytoplasm GO:1990904 - ribonucleoprotein complex
Homologous interactions	3

Homologous interactions

Color coding for hit scores

	1 1531 Hs			1 482
+	Hs
		508977 TOP2A_HUMAN (1-1531): 0: 1750: 100.00		G3BP1_HUMAN (1-460): 6.81e-83: 265: 56.81
+	Hs
		973414 TOP2B_HUMAN (14-1523): 0: 1644: 65.85		G3BP2_HUMAN (1-482): 5.94e-108: 330: 100.00
+	Sc
		420149 TOP2_YEAST (24-1404): 0: 1262: 41.63		BRE5_YEAST (9-419): 2.98e-56: 197: 15.59