HitPredict

Interactor 1: UBL4A (P11441)
Ubiquitin-like protein 4A (Ubiquitin-like protein GDX)
Gene: UBL4A

Interactor 2: TRAF4 (Q9BUZ4)
TNF receptor-associated factor 4 (EC 2.3.2.27) (Cysteine-rich domain associated with RING and Traf domains protein 1) (Metastatic lymph node gene 62 protein) (MLN 62) (RING finger protein 83)
Gene: TRAF4

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.81	1.00	0.904

Property	Details
Experiments	25416956, 21516116, 32296183, unassigned1304
Identification Methods	two hybrid, two hybrid prey pooling approach, two hybrid array, validated two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	ubiquitin~zf-C3HC4
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 157 Hs			1 470
+	Hs
		1237128 UBL4B_HUMAN (1-146): 2.55e-47: 153: 44.52		TRAF4_HUMAN (1-470): 5.03e-120: 361: 100.00
+	Mm
		476826 UBC_MOUSE (1-102): 1.77e-28: 111: 31.13		TRAF4_MOUSE (1-470): 1.84e-120: 362: 96.81
+	Hs
		475011 UBB_HUMAN (1-76): 1.43e-29: 109: 39.47		TRAF2_HUMAN (2-465): 4.35e-117: 354: 29.86
+	Hs
		475684 UBC_HUMAN (1-77): 1.92e-27: 108: 40.26		TRAF2_HUMAN (2-465): 4.35e-117: 354: 29.86
+	Rn
		78208 UBC_RAT (1-102): 9.46e-29: 112: 31.13		B5DFH7_RAT (2-465): 1.09e-113: 345: 30.24
+	Hs
		129527 UBC_HUMAN (1-77): 1.92e-27: 108: 40.26		TRAF5_HUMAN (2-465): 7.74e-104: 322: 24.95
+	Rn
		88507 UBC_RAT (1-102): 9.46e-29: 112: 31.13		D3Z9G0_RAT (3-465): 4.94e-101: 315: 24.17
+	Hs
		509753 UBL4A_HUMAN (1-157): 6.07e-43: 141: 100.00		TRAF6_HUMAN (3-464): 1.61e-84: 271: 24.79
+	Hs
		924227 RS27A_HUMAN (1-123): 2.9e-40: 134: 28.46		TRAF6_HUMAN (3-464): 1.61e-84: 271: 24.79
+	Hs
		475253 UBB_HUMAN (1-76): 1.43e-29: 109: 39.47		TRAF6_HUMAN (3-464): 1.61e-84: 271: 24.79
+	Dm
		547968 RS27A_DROME (1-123): 4.88e-39: 131: 28.46		Q9W3I9_DROME (2-464): 1.97e-72: 238: 19.49
+	Hs
		475013 UBB_HUMAN (1-76): 1.43e-29: 109: 39.47		TRAF1_HUMAN (16-465): 6.07e-72: 235: 24.18
+	Hs
		475691 UBC_HUMAN (1-77): 1.92e-27: 108: 40.26		TRAF1_HUMAN (16-465): 6.07e-72: 235: 24.18
+	Hs
		301744 RS27A_HUMAN (1-123): 2.9e-40: 134: 28.46		TRI37_HUMAN (5-465): 5.48e-55: 199: 13.81
+	Mm
		924236 RS27A_MOUSE (1-123): 2.97e-40: 134: 28.46		RO52_MOUSE (4-266): 2.26e-45: 166: 13.86
+	Hs
		924180 RS27A_HUMAN (1-123): 2.9e-40: 134: 28.46		ZNF71_HUMAN (4-216): 4.29e-41: 154: 13.95
+	Mm
		476831 UBC_MOUSE (1-102): 1.77e-28: 111: 31.13		RO52_MOUSE (4-266): 2.26e-45: 166: 13.86
+	Mm
		476671 UBB_MOUSE (1-76): 9.53e-29: 109: 39.47		RO52_MOUSE (4-266): 2.26e-45: 166: 13.86
+	Hs
		475328 UBC_HUMAN (1-77): 1.92e-27: 108: 40.26		RO52_HUMAN (9-286): 3.93e-44: 163: 14.84
+	Hs
		475125 UBB_HUMAN (1-76): 1.43e-29: 109: 39.47		RN166_HUMAN (9-146): 3.64e-16: 79.5: 25.90