HitPredict

Interactor 1: PRPS2 (P11908)
Ribose-phosphate pyrophosphokinase 2 (EC 2.7.6.1) (PPRibP) (Phosphoribosyl pyrophosphate synthase II) (PRS-II)
Gene: PRPS2

Interactor 2: NCK1 (P16333)
SH2/SH3 adapter protein NCK1 (Cytoplasmic protein NCK1) (NCK adapter protein 1) (Nck-1) (SH2/SH3 adapter protein NCK-alpha)
Gene: NCK1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	31980649, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 318 Hs			1 377
+	Hs
		557648 PRPS1_HUMAN (1-318): 3.91e-178: 496: 95.28		NCK1_HUMAN (1-377): 1.69e-98: 299: 100.00
+	Hs
		225839 KPRB_HUMAN (4-318): 1.36e-135: 390: 44.70		NCK1_HUMAN (1-377): 1.69e-98: 299: 100.00
+	Hs
		557692 KPRA_HUMAN (4-318): 5.53e-131: 378: 43.39		NCK1_HUMAN (1-377): 1.69e-98: 299: 100.00
+	Hs
		412112 PRPS1_HUMAN (1-318): 3.91e-178: 496: 95.28		FYN_HUMAN (7-173): 7.47e-21: 96: 15.39
+	Hs
		442805 PRPS1_HUMAN (1-318): 3.91e-178: 496: 95.28		HCK_HUMAN (2-174): 4.07e-20: 93.7: 17.24
+	Hs
		411967 PRPS2_HUMAN (1-318): 9.18e-177: 493: 100.00		FYN_HUMAN (7-173): 7.47e-21: 96: 15.39
+	Hs
		454819 PRPS1_HUMAN (1-318): 3.91e-178: 496: 95.28		FGR_HUMAN (7-150): 8.06e-20: 92.9: 20.00
+	Hs
		442769 PRPS2_HUMAN (1-318): 9.18e-177: 493: 100.00		HCK_HUMAN (2-174): 4.07e-20: 93.7: 17.24
+	Hs
		454793 PRPS2_HUMAN (1-318): 9.18e-177: 493: 100.00		FGR_HUMAN (7-150): 8.06e-20: 92.9: 20.00
+	Hs
		225829 KPRB_HUMAN (4-318): 1.36e-135: 390: 44.70		FYN_HUMAN (7-173): 7.47e-21: 96: 15.39
+	Hs
		225830 KPRB_HUMAN (4-318): 1.36e-135: 390: 44.70		HCK_HUMAN (2-174): 4.07e-20: 93.7: 17.24
+	Hs
		412194 KPRA_HUMAN (4-318): 5.53e-131: 378: 43.39		FYN_HUMAN (7-173): 7.47e-21: 96: 15.39
+	Hs
		442829 KPRA_HUMAN (4-318): 5.53e-131: 378: 43.39		HCK_HUMAN (2-174): 4.07e-20: 93.7: 17.24
+	Hs
		454831 KPRA_HUMAN (4-318): 5.53e-131: 378: 43.39		FGR_HUMAN (7-150): 8.06e-20: 92.9: 20.00