Protein: COFI
Cofilin (Actin-depolymerizing factor 1)

Gene: COFI, COF1
Organism: Saccharomyces cerevisiae S288C
Interactions: 98
UniProt ID: Q03048

Gene Ontology (top 5):
GO:0005737 - cytoplasm
GO:0005886 - plasma membrane
GO:0006897 - endocytosis
GO:0007015 - actin filament organization
GO:0015629 - actin cytoskeleton

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

948633

ACT
Actin

20

20

Small-scale

0.989

High

858538

AIP1
Actin-interacting protein 1

3

7

Small-scale

0.664

High

605340

CAP
Adenylyl cyclase-associated protein

2

9

High-throughput

0.621

High

1040600

COFI
Cofilin

1

12

Small-scale

0.621

High

555140

G6PI
Glucose-6-phosphate isomerase

2

0

High-throughput

0.569

High

368736

PMG1
Phosphoglycerate mutase 1

2

1

High-throughput

0.543

High

449172

CALM
Calmodulin

1

3

High-throughput

0.536

High

475136

CYAA
Adenylate cyclase

1

1

High-throughput

0.536

High

850964

TOS3
Serine/threonine-protein kinase TOS3

1

5

High-throughput

0.536

High

916898

IMB5
Importin subunit beta-5

1

2

High-throughput

0.536

High

1030561

UBP3
Ubiquitin carboxyl-terminal hydrolase 3

1

1

High-throughput

0.536

High

1040602

CORO
Coronin-like protein

1

6

High-throughput

0.536

High

850170

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

2

1

High-throughput

0.533

High

811636

YCFI
Metal resistance protein YCF1

1

2

High-throughput

0.532

High

575736

BPT1
Bile pigment transporter 1

1

2

High-throughput

0.518

High

736201

YBT1
ATP-dependent bile acid permease

1

3

High-throughput

0.518

High

744014

RAD23
UV excision repair protein RAD23

1

1

High-throughput

0.515

High

604557

PHO81
Phosphate system positive regulatory protein PHO81

1

0

High-throughput

0.513

High

666705

GRR1
SCF E3 ubiquitin ligase complex F-box protein GRR1

1

0

High-throughput

0.513

High

850397

YFI6
Uncharacterized protein YFR016C

1

0

High-throughput

0.513

High

924921

APP1
Phosphatidate phosphatase APP1

1

0

High-throughput

0.513

High

1040603

BUD20
Bud site selection protein 20

1

0

High-throughput

0.513

High

506381

NFT1
ABC transporter NFT1

1

3

High-throughput

0.494

High

633268

CKS1
Cyclin-dependent kinases regulatory subunit

1

0

High-throughput

0.493

High

1040610

LAS17
Proline-rich protein LAS17

1

0

Small-scale

0.493

High

808543

TEM1
Protein TEM1

1

2

High-throughput

0.489

High

477620

MYO1
Myosin-1

1

5

Small-scale

0.481

High

779877

MID2
Cell wall integrity sensor MID2

1

1

Small-scale

0.481

High

836324

BNI1
Protein BNI1

1

0

High-throughput

0.480

High

359054

G3P2
Glyceraldehyde-3-phosphate dehydrogenase 2

1

3

High-throughput

0.479

High

359330

G3P3
Glyceraldehyde-3-phosphate dehydrogenase 3

1

3

High-throughput

0.479

High

359519

G3P1
Glyceraldehyde-3-phosphate dehydrogenase 1

1

3

High-throughput

0.479

High

367802

ENO1
Enolase 1

1

3

High-throughput

0.479

High

368039

ENO2
Enolase 2

1

3

High-throughput

0.479

High

368479

TPIS
Triosephosphate isomerase

1

1

High-throughput

0.479

High

393219

HSP82
ATP-dependent molecular chaperone HSP82

1

1

High-throughput

0.479

High

416472

HXKA
Hexokinase-1

1

2

High-throughput

0.479

High

579948

HSC82
ATP-dependent molecular chaperone HSC82

1

1

High-throughput

0.479

High

849721

OTU1
Ubiquitin thioesterase OTU1

1

1

High-throughput

0.479

High

747753

SMC1
Structural maintenance of chromosomes protein 1

1

1

High-throughput

0.470

High

361977

HIS1
ATP phosphoribosyltransferase

1

0

High-throughput

0.458

High

365165

KPYK1
Pyruvate kinase 1

1

0

High-throughput

0.458

High

365684

PGK
Phosphoglycerate kinase

1

0

High-throughput

0.458

High

366727

HIS2
Histidine biosynthesis trifunctional protein [Includes: Phosphoribosyl-AMP cyclohydrolase

1

0

High-throughput

0.458

High

432357

METE
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase

1

0

High-throughput

0.458

High

439410

PDC1
Pyruvate decarboxylase isozyme 1

1

0

High-throughput

0.458

High

450744

KAD2
Adenylate kinase

1

0

High-throughput

0.458

High

452593

C1TC
C-1-tetrahydrofolate synthase, cytoplasmic

1

0

High-throughput

0.458

High

454127

DHE4
NADP-specific glutamate dehydrogenase 1

1

0

High-throughput

0.458

High

572640

ALF
Fructose-bisphosphate aldolase

1

0

High-throughput

0.458

High

575995

CYPH
Peptidyl-prolyl cis-trans isomerase

1

0

High-throughput

0.458

High

578249

TAL1
Transaldolase

1

0

High-throughput

0.458

High

605118

TPM1
Tropomyosin-1

1

0

Small-scale

0.458

High

655596

TKT1
Transketolase 1

1

0

High-throughput

0.458

High

733597

P5CR
Pyrroline-5-carboxylate reductase

1

0

High-throughput

0.458

High

750760

PRS6A
26S proteasome regulatory subunit 6A

1

0

High-throughput

0.458

High

775985

TCTP
Translationally-controlled tumor protein homolog

1

0

High-throughput

0.458

High

802971

6PGD1
6-phosphogluconate dehydrogenase, decarboxylating 1

1

0

High-throughput

0.458

High

803664

RPN1
26S proteasome regulatory subunit RPN1

1

0

High-throughput

0.458

High

815746

SAHH
Adenosylhomocysteinase

1

0

High-throughput

0.458

High

834723

GPP1
Glycerol-1-phosphate phosphohydrolase 1

1

0

High-throughput

0.458

High

910767

SKP1
Suppressor of kinetochore protein 1

1

0

Small-scale

0.458

High

1040605

ZEO1
Protein ZEO1

1

0

High-throughput

0.458

High

554957

ODP2
Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial

1

1

High-throughput

0.457

High

524944

HSP71
Heat shock protein SSA1

1

4

High-throughput

0.445

High

527513

HSP72
Heat shock protein SSA2

1

4

High-throughput

0.445

High

546022

SSB1
Ribosome-associated molecular chaperone SSB1

1

4

High-throughput

0.445

High

742254

HSP7F
Heat shock protein homolog SSE1

1

6

High-throughput

0.445

High

819608

SSB2
Ribosome-associated molecular chaperone SSB2

1

4

High-throughput

0.445

High

506403

YK104
Putative uncharacterized protein YKR104W

1

3

High-throughput

0.439

High

826396

MPH1
ATP-dependent DNA helicase MPH1

1

1

Small-scale

0.439

High

361012

CCPR
Cytochrome c peroxidase, mitochondrial

1

1

Small-scale

0.437

High

361451

SODC
Superoxide dismutase [Cu-Zn]

1

1

High-throughput

0.437

High

416565

HXKB
Hexokinase-2

1

2

High-throughput

0.437

High

755157

GCN1
eIF-2-alpha kinase activator GCN1

1

0

High-throughput

0.279

Low

933118

ORN
Oligoribonuclease, mitochondrial

1

0

High-throughput

0.279

Low

1040601

SEN15
tRNA-splicing endonuclease subunit SEN15

1

0

High-throughput

0.279

Low

1040606

DIA2
Protein DIA2

1

0

High-throughput

0.279

Low

797442

MKAR
Very-long-chain 3-oxoacyl-CoA reductase

1

0

High-throughput

0.269

Low

823601

RIC1
Guanine nucleotide exchange factor subunit RIC1

1

0

High-throughput

0.269

Low

917901

PUS2
tRNA pseudouridine(27/28) synthase

1

0

High-throughput

0.269

Low

1040604

THI20
Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase THI20

1

0

High-throughput

0.261

Low

1038090

ULP1
Ubiquitin-like-specific protease 1

1

0

High-throughput

0.251

Low

610190

PDI
Protein disulfide-isomerase

1

0

High-throughput

0.249

Low

671052

SIS1
Protein SIS1

1

0

High-throughput

0.249

Low

707988

TF2B
Transcription initiation factor IIB

1

0

High-throughput

0.249

Low

737386

EF1B
Elongation factor 1-beta

1

0

High-throughput

0.249

Low

795175

NU170
Nucleoporin NUP170

1

0

High-throughput

0.249

Low

795651

UBP13
Ubiquitin carboxyl-terminal hydrolase 13

1

0

High-throughput

0.249

Low

806804

RPN10
26S proteasome regulatory subunit RPN10

1

0

High-throughput

0.249

Low

820486

MMF1
Protein MMF1, mitochondrial

1

0

High-throughput

0.249

Low

865721

MOG1
Nuclear import protein MOG1

1

0

High-throughput

0.249

Low

925376

SAM50
Sorting assembly machinery 50 kDa subunit

1

0

High-throughput

0.249

Low

926272

ALDH6
Magnesium-activated aldehyde dehydrogenase, cytosolic

1

0

High-throughput

0.249

Low

1040607

AP3D
AP-3 complex subunit delta

1

0

High-throughput

0.249

Low

1040608

RRP6
Exosome complex exonuclease RRP6

1

0

High-throughput

0.249

Low

1040609

JID1
J domain-containing protein 1

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025