HitPredict

Interactor 1: PABP1 (P11940)
Polyadenylate-binding protein 1 (PABP-1) (Poly(A)-binding protein 1)
Gene: PABPC1

Interactor 2: AGO1 (Q9UL18)
Protein argonaute-1 (Argonaute1) (hAgo1) (Argonaute RISC catalytic component 1) (Eukaryotic translation initiation factor 2C 1) (eIF-2C 1) (eIF2C 1) (Putative RNA-binding protein Q99)
Gene: AGO1

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.70	0.60	0.650

Property	Details
Experiments	29395067, 19716330, 17932509
Identification Methods	proximity labelling technology, affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003723 - RNA binding GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0036464 - cytoplasmic ribonucleoprotein granule
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 636 Hs			1 857
+	Mm
		665763 PABP1_MOUSE (1-636): 0: 581: 99.69		AGO2_MOUSE (3-857): 0: 1213: 82.36
+	Hs
		516735 PABP1_HUMAN (1-636): 0: 582: 100.00		AGO2_HUMAN (19-857): 0: 1206: 83.43
+	Hs
		516695 PABP1_HUMAN (1-636): 0: 582: 100.00		AGO3_HUMAN (1-857): 0: 1189: 83.83
+	Hs
		1329989 PABP3_HUMAN (1-636): 0: 541: 91.37		AGO1_HUMAN (1-857): 0: 1222: 100.00
+	Hs
		516701 PABP1_HUMAN (1-636): 0: 582: 100.00		AGO4_HUMAN (9-857): 0: 1167: 83.04
+	Mm
		1208650 Q99LF8_MOUSE (1-635): 3.01e-176: 517: 71.99		AGO2_MOUSE (3-857): 0: 1213: 82.36
+	Hs
		1031470 PABP4_HUMAN (1-635): 0: 534: 74.69		AGO4_HUMAN (9-857): 0: 1167: 83.04
+	Hs
		582551 NUCL_HUMAN (3-89): 2.56e-19: 94.1: 33.33		AGO1_HUMAN (1-857): 0: 1222: 100.00
+	Ce
		108515 Q19581_CAEEL (6-113): 4.07e-15: 80.7: 26.85		G5EGR6_CAEEL (21-857): 0: 1109: 66.36
+	Dm
		284331 PABP_DROME (2-448): 6.58e-63: 221: 25.21		AUB_DROME (2-815): 0: 596: 21.60