Protein: LRIG1
Leucine-rich repeats and immunoglobulin-like domains protein 1 (LIG-1)

Gene: LRIG1
Organism: Homo sapiens
Interactions: 67
UniProt ID: Q96JA1

Gene Ontology (top 5):
GO:0005615 - extracellular space
GO:0005886 - plasma membrane
GO:0007605 - sensory perception of sound
GO:0022405 - hair cycle process
GO:0031012 - extracellular matrix

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

363715

EGFR
Epidermal growth factor receptor

5

20

Small-scale

0.921

High

411002

ERBB2
Receptor tyrosine-protein kinase erbB-2

4

20

Small-scale

0.886

High

1145766

ERBB4
Receptor tyrosine-protein kinase erbB-4

3

20

Small-scale

0.871

High

1249978

LRIG3
Leucine-rich repeats and immunoglobulin-like domains protein 3

3

20

Small-scale

0.867

High

1144655

PTPRK
Receptor-type tyrosine-protein phosphatase kappa

3

6

High-throughput

0.861

High

320888

LRIG2
Leucine-rich repeats and immunoglobulin-like domains protein 2

2

20

High-throughput

0.811

High

568083

HLAE
HLA class I histocompatibility antigen, alpha chain E

2

3

High-throughput

0.811

High

1122310

SCRIB
Protein scribble homolog

2

20

High-throughput

0.811

High

380335

DRA
HLA class II histocompatibility antigen, DR alpha chain

2

5

High-throughput

0.789

High

472116

MET
Hepatocyte growth factor receptor

2

19

Small-scale

0.776

High

630932

RAB4A
Ras-related protein Rab-4A

2

4

High-throughput

0.726

High

1394725

LRC40
Leucine-rich repeat-containing protein 40

2

20

High-throughput

0.726

High

593469

PGFRA
Platelet-derived growth factor receptor alpha

1

9

High-throughput

0.691

High

688615

NKG2A
NKG2-A/NKG2-B type II integral membrane protein

1

17

High-throughput

0.691

High

1143773

PON2
Serum paraoxonase/arylesterase 2

3

2

High-throughput

0.667

High

1394722

G3ST1
Galactosylceramide sulfotransferase

3

1

High-throughput

0.667

High

641652

ERBB3
Receptor tyrosine-protein kinase erbB-3

1

20

Small-scale

0.665

High

1394727

TMPS4
Transmembrane protease serine 4

1

12

High-throughput

0.665

High

1358461

CANT1
Soluble calcium-activated nucleotidase 1

3

0

High-throughput

0.638

High

1101402

SG2A2
Mammaglobin-A

2

2

High-throughput

0.628

High

1394720

GML
Glycosyl-phosphatidylinositol-anchored molecule-like protein

2

1

High-throughput

0.628

High

416639

REL1
Prorelaxin H1 [Cleaved into: Relaxin B chain; Relaxin A chain]

1

2

High-throughput

0.618

High

1177865

CL12B
C-type lectin domain family 12 member B

1

13

High-throughput

0.618

High

1248785

LYZL1
Lysozyme-like protein 1

1

1

High-throughput

0.618

High

1394731

INSL5
Insulin-like peptide INSL5

1

1

High-throughput

0.618

High

464032

RET
Proto-oncogene tyrosine-protein kinase receptor Ret

1

20

Small-scale

0.618

High

901487

RAB7A
Ras-related protein Rab-7a

1

4

High-throughput

0.618

High

1286867

TM11B
Transmembrane protease serine 11B

1

13

High-throughput

0.618

High

1360914

CLC4D
C-type lectin domain family 4 member D

1

10

High-throughput

0.618

High

1231136

SCAR3
Scavenger receptor class A member 3

3

2

High-throughput

0.609

High

834647

NBL1
Neuroblastoma suppressor of tumorigenicity 1

2

0

High-throughput

0.580

High

1191934

TBB8
Tubulin beta-8 chain

2

3

High-throughput

0.574

High

1394723

CNPY3
Protein canopy homolog 3

2

11

High-throughput

0.574

High

651406

CBL
E3 ubiquitin-protein ligase CBL

1

2

Small-scale

0.561

High

1255082

TRI67
Tripartite motif-containing protein 67

1

8

High-throughput

0.553

High

1359435

LMO7
LIM domain only protein 7

1

5

Small-scale

0.553

High

1360115

NALP7
NACHT, LRR and PYD domains-containing protein 7

1

12

High-throughput

0.553

High

1394730

LIMC1
LIM and calponin homology domains-containing protein 1

1

4

Small-scale

0.553

High

170920

CLGN
Calmegin

2

12

High-throughput

0.549

High

1394729

FBX2
F-box only protein 2

2

12

High-throughput

0.549

High

948011

DEF1
Neutrophil defensin 1

1

2

High-throughput

0.536

High

49813

CLRN2
Clarin-2

1

0

High-throughput

0.513

High

829039

IL15
Interleukin-15

1

0

High-throughput

0.513

High

1292597

IFNE
Interferon epsilon

1

0

High-throughput

0.513

High

1322739

CNPY4
Protein canopy homolog 4

1

11

High-throughput

0.489

High

1359224

CA054
Uncharacterized protein C1orf54

1

2

High-throughput

0.489

High

1382365

SPSB4
SPRY domain-containing SOCS box protein 4

1

16

High-throughput

0.489

High

1394721

SPSB2
SPRY domain-containing SOCS box protein 2

1

13

High-throughput

0.489

High

828240

UBP8
Ubiquitin carboxyl-terminal hydrolase 8

1

2

Small-scale

0.479

High

1249120

LMBRL
Protein LMBR1L

1

2

High-throughput

0.479

High

300208

GLRX3
Glutaredoxin-3

1

4

Small-scale

0.464

High

1010965

BAT1
b(0,+)-type amino acid transporter 1

1

3

High-throughput

0.445

High

1031843

LAT1
Large neutral amino acids transporter small subunit 1

1

3

High-throughput

0.445

High

1065016

FGL1
Fibrinogen-like protein 1

1

2

High-throughput

0.445

High

1133801

SL9A5
Sodium/hydrogen exchanger 5

1

3

High-throughput

0.445

High

1359483

CTL1
Choline transporter-like protein 1

1

1

High-throughput

0.445

High

169704

HGS
Hepatocyte growth factor-regulated tyrosine kinase substrate

1

1

Small-scale

0.437

High

935005

TERA
Transitional endoplasmic reticulum ATPase

1

2

High-throughput

0.437

High

1394726

ANKH
Mineralization regulator ANKH

1

0

High-throughput

0.426

High

1394724

MFR1L
Mitochondrial fission regulator 1-like

2

0

High-throughput

0.328

High

1211189

ODR4
Protein odr-4 homolog

1

0

High-throughput

0.279

Low

1362521

SIA8D
CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferase

1

0

High-throughput

0.279

Low

1392426

TECT2
Tectonic-2

1

0

High-throughput

0.279

Low

1394728

UFSP2
Ufm1-specific protease 2

1

0

High-throughput

0.279

Low

1051404

ZBT16
Zinc finger and BTB domain-containing protein 16

1

0

Small-scale

0.265

Low

414413

P53
Cellular tumor antigen p53

1

0

High-throughput

0.249

Low

571498

GLU2B
Glucosidase 2 subunit beta

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025