HitPredict

Interactor 1: PCNA (P12004)
Proliferating cell nuclear antigen (PCNA) (Cyclin)
Gene: PCNA

Interactor 2: UHRF2 (Q96PU4)
E3 ubiquitin-protein ligase UHRF2 (EC 2.3.2.27) (Np95/ICBP90-like RING finger protein) (Np95-like RING finger protein) (Nuclear protein 97) (Nuclear zinc finger protein Np97) (RING finger protein 107) (RING-type E3 ubiquitin transferase UHRF2) (Ubiquitin-like PHD and RING finger domain-containing protein 2) (Ubiquitin-like-containing PHD and RING finger domains protein 2)
Gene: UHRF2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.74	1.00	0.865

Property	Details
Experiments	28951215, 27114453, 21952639
Identification Methods	x-ray crystallography, unspecified method, affinity chromatography technology, far western blotting, antibody array
Interaction Type	association, direct interaction, physical association

Property	Details
Interacting Pfam domains	PCNA_C~ubiquitin
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	4

Homologous interactions

Color coding for hit scores

	1 261 Hs			1 802
+	Hs
		517419 PCNA_HUMAN (1-261): 1.04e-125: 359: 100.00		UHRF1_HUMAN (1-802): 0: 817: 53.01
+	Dm
		332856 PCNA2_DROME (1-259): 3.01e-106: 309: 47.88		CHDM_DROME (257-672): 8.56e-67: 244: 16.16
+	Hs
		517117 PCNA_HUMAN (1-261): 1.04e-125: 359: 100.00		KDM5C_HUMAN (251-428): 3.26e-34: 143: 16.36
+	At
		1258482 PCNA1_ARATH (1-261): 8.59e-119: 342: 64.75		ATXR5_ARATH (307-442): 8.76e-25: 109: 18.54