HitPredict

Interactor 1: CADH1 (P12830)
Cadherin-1 (CAM 120/80) (Epithelial cadherin) (E-cadherin) (Uvomorulin) (CD antigen CD324) [Cleaved into: E-Cad/CTF1; E-Cad/CTF2; E-Cad/CTF3]
Gene: CDH1

Interactor 2: FAK1 (Q05397)
Focal adhesion kinase 1 (FADK 1) (EC 2.7.10.2) (Focal adhesion kinase-related nonkinase) (FRNK) (Protein phosphatase 1 regulatory subunit 71) (PPP1R71) (Protein-tyrosine kinase 2) (p125FAK) (pp125FAK)
Gene: PTK2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	35525274
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0022408 - negative regulation of cell-cell adhesion GO:0048471 - perinuclear region of cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 882 Hs			1 1052
+	Hs
		521709 CADH1_HUMAN (1-882): 0: 836: 100.00		FER_HUMAN (86-682): 1.71e-137: 436: 24.84
+	Hs
		521738 CADH1_HUMAN (1-882): 0: 836: 100.00		MARK3_HUMAN (367-1026): 1.59e-119: 386: 16.85
+	Hs
		521744 CADH1_HUMAN (1-882): 0: 836: 100.00		EPHA2_HUMAN (369-774): 9.75e-117: 385: 30.73
+	Hs
		411968 CADH1_HUMAN (1-882): 0: 836: 100.00		FYN_HUMAN (265-689): 7.19e-119: 377: 26.68
+	Hs
		507817 CADH1_HUMAN (1-882): 0: 836: 100.00		FGFR1_HUMAN (331-734): 2.82e-114: 374: 27.64
+	Hs
		521694 CADH1_HUMAN (1-882): 0: 836: 100.00		SRC_HUMAN (415-689): 1.19e-113: 363: 38.77
+	Hs
		433230 CADH1_HUMAN (1-882): 0: 836: 100.00		YES_HUMAN (415-689): 7.31e-112: 359: 37.68
+	Hs
		580236 CADH2_HUMAN (28-881): 0: 769: 45.86		EPHA7_HUMAN (388-756): 5.73e-121: 397: 32.53
+	Hs
		580213 CADH2_HUMAN (28-881): 0: 769: 45.86		EPHA4_HUMAN (372-763): 1.33e-119: 393: 31.90
+	Hs
		507842 CADH2_HUMAN (28-881): 0: 769: 45.86		FGFR1_HUMAN (331-734): 2.82e-114: 374: 27.64
+	Hs
		872427 DSC2_HUMAN (33-874): 0: 652: 27.88		EPHA5_HUMAN (208-760): 5.09e-123: 403: 26.17
+	Hs
		971014 DSC2_HUMAN (33-874): 0: 652: 27.88		EPHA7_HUMAN (388-756): 5.73e-121: 397: 32.53
+	Hs
		872632 DSC2_HUMAN (33-874): 0: 652: 27.88		EPHA4_HUMAN (372-763): 1.33e-119: 393: 31.90
+	Hs
		665215 DSC2_HUMAN (33-874): 0: 652: 27.88		EPHA2_HUMAN (369-774): 9.75e-117: 385: 30.73
+	Hs
		508000 DSC3_HUMAN (2-874): 0: 655: 27.92		FGFR1_HUMAN (331-734): 2.82e-114: 374: 27.64
+	Hs
		374113 DSC1_HUMAN (33-769): 0: 640: 33.11		RAF1_HUMAN (106-714): 1.08e-119: 383: 16.88
+	Hs
		433353 DSC3_HUMAN (2-874): 0: 655: 27.92		YES_HUMAN (415-689): 7.31e-112: 359: 37.68
+	Hs
		411680 DSC2_HUMAN (33-874): 0: 652: 27.88		LCK_HUMAN (412-691): 7.42e-111: 355: 37.37
+	Hs
		507929 CAD11_HUMAN (3-481): 2.6e-77: 269: 20.16		FGFR1_HUMAN (331-734): 2.82e-114: 374: 27.64
+	Hs
		508294 PCDB7_HUMAN (385-867): 7.31e-69: 246: 15.22		FGFR1_HUMAN (331-734): 2.82e-114: 374: 27.64