HitPredict

Interactor 1: PEP5 (P12868)
E3 ubiquitin-protein ligase PEP5 (EC 2.3.2.27) (Carboxypeptidase Y-deficient protein 5) (Histone E3 ligase PEP5) (RING-type E3 ubiquitin transferase PEP5) (Vacuolar biogenesis protein END1) (Vacuolar morphogenesis protein 1) (Vacuolar protein sorting-associated protein 11) (Vacuolar protein-targeting protein 11)
Gene: PEP5

Interactor 2: VPS8 (P39702)
Vacuolar protein sorting-associated protein 8 (Vacuolar protein-targeting protein 8)
Gene: VPS8

Species: Saccharomyces cerevisiae S288C

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.94 0.60 0.752

The method score is based on:

Property Details
Experiments 11805826, 21325627, 20604902, 23840658, 15047864, 16429126, 23417307, 37968396, 20173035
Identification Methods tandem affinity purification, two hybrid, affinity chromatography technology
Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0030897 - HOPS complex
GO:0031901 - early endosome membrane
GO:0032889 - regulation of vacuole fusion, non-autophagic
GO:0033263 - CORVET complex
GO:0046872 - metal ion binding
and 1 others

more...
Homologous interactions 1

Homologous interactions

Color coding for hit scores

1 1029
Sc

1 1274
+ Hs

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024