HitPredict

Interactor 1: LYL1 (P12980)
Protein lyl-1 (Class A basic helix-loop-helix protein 18) (bHLHa18) (Lymphoblastic leukemia-derived sequence 1)
Gene: LYL1

Interactor 2: RBTN2 (P25791)
Rhombotin-2 (Cysteine-rich protein TTG-2) (LIM domain only protein 2) (LMO-2) (T-cell translocation protein 2)
Gene: LMO2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.621

Property	Details
Experiments	7957052
Identification Methods	two hybrid
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	HLH~LIM
Common GO terms	GO:0005654 - nucleoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 280 Hs			1 158
+	Hs
		524538 LYL1_HUMAN (1-280): 1e-53: 177: 100.00		RBTN1_HUMAN (11-150): 2.04e-38: 129: 52.86
+	Hs
		1148470 FIGLA_HUMAN (96-280): 1.36e-29: 113: 26.04		LHX8_HUMAN (24-148): 1.1e-47: 159: 33.60
+	Hs
		568179 TAL1_HUMAN (51-267): 1.7e-34: 128: 40.83		RBTN2_HUMAN (1-158): 4.5e-41: 136: 100.00
+	Mm
		603898 TAL1_MOUSE (55-219): 1.79e-32: 123: 45.78		RBTN2_MOUSE (1-158): 3.35e-41: 137: 99.37
+	Hs
		568180 TAL1_HUMAN (51-267): 1.7e-34: 128: 40.83		RBTN1_HUMAN (11-150): 2.04e-38: 129: 52.86
+	Mm
		604035 TAL1_MOUSE (55-219): 1.79e-32: 123: 45.78		LMO3_MOUSE (30-156): 5.7e-39: 130: 58.27
+	Hs
		1163324 FIGLA_HUMAN (96-280): 1.36e-29: 113: 26.04		LHX6_HUMAN (7-153): 2.16e-38: 135: 27.70
+	Hs
		210862 TCF21_HUMAN (130-209): 1.64e-27: 106: 39.51		LMO4_HUMAN (11-147): 3.1e-39: 132: 42.34
+	Hs
		638295 TAL2_HUMAN (149-215): 7.25e-27: 102: 67.16		RBTN2_HUMAN (1-158): 4.5e-41: 136: 100.00
+	Hs
		546094 MYOG_HUMAN (95-279): 5.4e-27: 106: 18.42		LMO3_HUMAN (30-156): 5.7e-39: 130: 58.27
+	Mm
		1143746 TAL2_MOUSE (149-237): 1.4e-27: 104: 53.85		LMO3_MOUSE (30-156): 5.7e-39: 130: 58.27
+	Mm
		1143747 TAL2_MOUSE (149-237): 1.4e-27: 104: 53.85		RBTN1_MOUSE (11-150): 3.96e-38: 128: 52.86
+	Hs
		638508 TAL2_HUMAN (149-215): 7.25e-27: 102: 67.16		RBTN1_HUMAN (11-150): 2.04e-38: 129: 52.86
+	Dm
		114761 Q9VHG3_DROME (26-234): 1.6e-32: 122: 21.10		M9PD53_DROME (2-86): 7.78e-15: 72.3: 17.44
+	Dm
		1359764 Q9VHG3_DROME (26-234): 1.6e-32: 122: 21.10		Q9V472_DROME (94-155): 1.72e-09: 56.9: 22.58
+	Hs
		1163323 FIGLA_HUMAN (96-280): 1.36e-29: 113: 26.04		LHX3_HUMAN (92-155): 2.6e-12: 65: 23.44
+	Dm
		80870 DIMM_DROME (97-249): 3.54e-28: 113: 21.38		APTE_DROME (94-155): 2.27e-11: 62.3: 20.97
+	Dm
		1368265 Q9W4I4_DROME (148-208): 3.36e-25: 100: 50.82		Q9VJ00_DROME (2-86): 1.05e-14: 71.9: 17.44
+	Hs
		551558 TFE2_HUMAN (18-254): 5.92e-28: 114: 18.60		LMX1A_HUMAN (89-155): 3.3e-09: 56.1: 17.91
+	Dm
		112565 Q9W4I4_DROME (148-208): 3.36e-25: 100: 50.82		M9NCY1_DROME (2-86): 7.53e-12: 63.8: 17.44