HitPredict

Interactor 1: LYL1 (P12980)
Protein lyl-1 (Class A basic helix-loop-helix protein 18) (bHLHa18) (Lymphoblastic leukemia-derived sequence 1)
Gene: LYL1

Interactor 2: ID3 (Q02535)
DNA-binding protein inhibitor ID-3 (Class B basic helix-loop-helix protein 25) (bHLHb25) (Helix-loop-helix protein HEIR-1) (ID-like protein inhibitor HLH 1R21) (Inhibitor of DNA binding 3) (Inhibitor of differentiation 3)
Gene: ID3

Species: Homo sapiens

Source: innatedb

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	18160048
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	HLH~HLH
Common GO terms	GO:0005654 - nucleoplasm GO:0046983 - protein dimerization activity
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 280 Hs			1 119
+	Hs
		524547 LYL1_HUMAN (1-280): 1e-53: 177: 100.00		ID1_HUMAN (1-100): 6.35e-42: 137: 47.22
+	Hs
		551503 TFE2_HUMAN (18-254): 5.92e-28: 114: 18.60		ID3_HUMAN (1-119): 1.28e-63: 190: 100.00
+	Hs
		526744 MYF5_HUMAN (116-254): 6.42e-28: 109: 21.99		ID3_HUMAN (1-119): 1.28e-63: 190: 100.00
+	Mm
		485938 MYOD1_MOUSE (100-280): 2.2e-28: 112: 24.31		ID3_MOUSE (1-119): 9.94e-62: 186: 96.64
+	Hs
		524549 LYL1_HUMAN (1-280): 1e-53: 177: 100.00		ID4_HUMAN (1-88): 8.56e-27: 98.6: 40.71
+	Mm
		589139 TAL1_MOUSE (55-219): 1.79e-32: 123: 45.78		ID1_MOUSE (3-100): 5.07e-42: 137: 46.60
+	Hs
		551502 TFE2_HUMAN (18-254): 5.92e-28: 114: 18.60		ID2_HUMAN (1-118): 8.98e-43: 138: 39.13
+	Hs
		551478 TFE2_HUMAN (18-254): 5.92e-28: 114: 18.60		ID1_HUMAN (1-100): 6.35e-42: 137: 47.22
+	Mm
		485939 MYOD1_MOUSE (100-280): 2.2e-28: 112: 24.31		ID2_MOUSE (1-118): 2.33e-42: 137: 38.41
+	Hs
		526743 MYF5_HUMAN (116-254): 6.42e-28: 109: 21.99		ID2_HUMAN (1-118): 8.98e-43: 138: 39.13
+	Mm
		485951 MYOD1_MOUSE (100-280): 2.2e-28: 112: 24.31		Q6GTZ3_MOUSE (3-100): 6.94e-41: 134: 46.60
+	Hs
		526742 MYF5_HUMAN (116-254): 6.42e-28: 109: 21.99		ID1_HUMAN (1-100): 6.35e-42: 137: 47.22
+	Hs
		111607 K7EMM4_HUMAN (38-254): 1.05e-27: 108: 18.72		ID1_HUMAN (1-100): 6.35e-42: 137: 47.22
+	Hs
		546071 MYOG_HUMAN (95-279): 5.4e-27: 106: 18.42		ID1_HUMAN (1-100): 6.35e-42: 137: 47.22
+	Hs
		568188 TAL1_HUMAN (51-267): 1.7e-34: 128: 40.83		ID4_HUMAN (1-88): 8.56e-27: 98.6: 40.71
+	Hs
		551480 TFE2_HUMAN (18-254): 5.92e-28: 114: 18.60		ID4_HUMAN (1-88): 8.56e-27: 98.6: 40.71
+	Hs
		814909 FIGLA_HUMAN (96-280): 1.36e-29: 113: 26.04		ID4_HUMAN (1-88): 8.56e-27: 98.6: 40.71
+	Hs
		616610 MYF6_HUMAN (46-263): 2.83e-29: 112: 18.35		ID4_HUMAN (1-88): 8.56e-27: 98.6: 40.71
+	Hs
		546072 MYOG_HUMAN (95-279): 5.4e-27: 106: 18.42		ID4_HUMAN (1-88): 8.56e-27: 98.6: 40.71
+	Dm
		509355 DA_DROME (42-279): 7.08e-28: 114: 16.13		EMC_DROME (43-94): 1.17e-18: 79: 43.40