HitPredict

Interactor 1: XRCC5 (P13010)
X-ray repair cross-complementing protein 5 (EC 3.6.4.-) (86 kDa subunit of Ku antigen) (ATP-dependent DNA helicase 2 subunit 2) (ATP-dependent DNA helicase II 80 kDa subunit) (CTC box-binding factor 85 kDa subunit) (CTC85) (CTCBF) (DNA repair protein XRCC5) (Ku80) (Ku86) (Lupus Ku autoantigen protein p86) (Nuclear factor IV) (Thyroid-lupus autoantigen) (TLAA) (X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining))
Gene: XRCC5

Interactor 2: H2B1C (P62807)
Histone H2B type 1-C/E/F/G/I (Histone H2B.1 A) (Histone H2B.a) (H2B/a) (Histone H2B.g) (H2B/g) (Histone H2B.h) (H2B/h) (Histone H2B.k) (H2B/k) (Histone H2B.l) (H2B/l)
Gene: H2BC4

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	34079125
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003677 - DNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 732 Hs			1 126
+	Hs
		524943 XRCC5_HUMAN (1-732): 0: 755: 100.00		H2B2E_HUMAN (1-126): 5.61e-54: 166: 99.21
+	Hs
		524806 XRCC5_HUMAN (1-732): 0: 755: 100.00		H2B1B_HUMAN (1-126): 1.52e-53: 165: 97.62
+	Hs
		523652 XRCC6_HUMAN (3-609): 3.61e-141: 429: 14.49		H2B1C_HUMAN (1-126): 1.05e-53: 166: 100.00
+	Hs
		523794 XRCC6_HUMAN (3-609): 3.61e-141: 429: 14.49		H2B2E_HUMAN (1-126): 5.61e-54: 166: 99.21
+	Hs
		523545 XRCC6_HUMAN (3-609): 3.61e-141: 429: 14.49		H2B1B_HUMAN (1-126): 1.52e-53: 165: 97.62
+	Hs
		523921 XRCC6_HUMAN (3-609): 3.61e-141: 429: 14.49		H2B1A_HUMAN (1-126): 3.14e-46: 147: 84.25
+	Sc
		356005 KU80_YEAST (8-622): 1.51e-99: 321: 14.03		H2B2_YEAST (3-125): 5.51e-37: 124: 71.55
+	Sc
		355631 KU80_YEAST (8-622): 1.51e-99: 321: 14.03		H2B1_YEAST (3-125): 1.92e-36: 122: 71.55
+	Sc
		355839 KU70_YEAST (8-541): 5.97e-92: 300: 16.73		H2B2_YEAST (3-125): 5.51e-37: 124: 71.55
+	Sc
		355416 KU70_YEAST (8-541): 5.97e-92: 300: 16.73		H2B1_YEAST (3-125): 1.92e-36: 122: 71.55