HitPredict

Interactor 1: XRCC5 (P13010)
X-ray repair cross-complementing protein 5 (EC 3.6.4.-) (86 kDa subunit of Ku antigen) (ATP-dependent DNA helicase 2 subunit 2) (ATP-dependent DNA helicase II 80 kDa subunit) (CTC box-binding factor 85 kDa subunit) (CTC85) (CTCBF) (DNA repair protein XRCC5) (Ku80) (Ku86) (Lupus Ku autoantigen protein p86) (Nuclear factor IV) (Thyroid-lupus autoantigen) (TLAA) (X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining))
Gene: XRCC5

Interactor 2: ELF3 (P78545)
ETS-related transcription factor Elf-3 (E74-like factor 3) (Epithelial-restricted with serine box) (Epithelium-restricted Ets protein ESX) (Epithelium-specific Ets transcription factor 1) (ESE-1)
Gene: ELF3

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.52	0.60	0.561

Property	Details
Experiments	15075319
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0045892 - negative regulation of DNA-templated transcription
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 732 Hs			1 371
+	Hs
		524778 XRCC5_HUMAN (1-732): 0: 755: 100.00		ETS1_HUMAN (18-366): 1.92e-89: 278: 19.48
+	Hs
		525086 XRCC5_HUMAN (1-732): 0: 755: 100.00		EHF_HUMAN (22-365): 8.41e-86: 263: 34.77
+	Hs
		507356 XRCC5_HUMAN (1-732): 0: 755: 100.00		ERG_HUMAN (47-354): 9.27e-81: 256: 20.46
+	Hs
		524842 XRCC5_HUMAN (1-732): 0: 755: 100.00		ETV1_HUMAN (147-361): 2.01e-51: 180: 21.40
+	Hs
		524786 XRCC5_HUMAN (1-732): 0: 755: 100.00		SPI1_HUMAN (101-360): 7.29e-47: 162: 21.75
+	Hs
		524841 XRCC5_HUMAN (1-732): 0: 755: 100.00		ERF_HUMAN (247-357): 1.89e-39: 148: 35.14
+	Hs
		523665 XRCC6_HUMAN (3-609): 3.61e-141: 429: 14.49		ELF3_HUMAN (1-371): 9.78e-139: 401: 100.00
+	Hs
		523492 XRCC6_HUMAN (3-609): 3.61e-141: 429: 14.49		ETS1_HUMAN (18-366): 1.92e-89: 278: 19.48
+	Hs
		524045 XRCC6_HUMAN (3-609): 3.61e-141: 429: 14.49		EHF_HUMAN (22-365): 8.41e-86: 263: 34.77
+	Hs
		507355 XRCC6_HUMAN (3-609): 3.61e-141: 429: 14.49		ERG_HUMAN (47-354): 9.27e-81: 256: 20.46
+	Hs
		523603 XRCC6_HUMAN (3-609): 3.61e-141: 429: 14.49		ETV1_HUMAN (147-361): 2.01e-51: 180: 21.40
+	Hs
		523507 XRCC6_HUMAN (3-609): 3.61e-141: 429: 14.49		SPI1_HUMAN (101-360): 7.29e-47: 162: 21.75