HitPredict

Interactor 1: XRCC5 (P13010)
X-ray repair cross-complementing protein 5 (EC 3.6.4.-) (86 kDa subunit of Ku antigen) (ATP-dependent DNA helicase 2 subunit 2) (ATP-dependent DNA helicase II 80 kDa subunit) (CTC box-binding factor 85 kDa subunit) (CTC85) (CTCBF) (DNA repair protein XRCC5) (Ku80) (Ku86) (Lupus Ku autoantigen protein p86) (Nuclear factor IV) (Thyroid-lupus autoantigen) (TLAA) (X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining))
Gene: XRCC5

Interactor 2: WDR76 (Q9H967)
WD repeat-containing protein 76
Gene: WDR76

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.71	0.60	0.656

Property	Details
Experiments	25817432, 27248496, 31353912
Identification Methods	affinity chromatography technology, biochemical
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003677 - DNA binding GO:0005634 - nucleus GO:0006974 - DNA damage response GO:0090734 - site of DNA damage
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 732 Hs			1 626
+	Hs
		525001 XRCC5_HUMAN (1-732): 0: 755: 100.00		DDB2_HUMAN (201-625): 1.38e-70: 236: 21.51
+	Hs
		524866 XRCC5_HUMAN (1-732): 0: 755: 100.00		WDR5_HUMAN (435-622): 2.2e-42: 157: 12.23
+	Hs
		524011 XRCC6_HUMAN (3-609): 3.61e-141: 429: 14.49		WDR76_HUMAN (1-626): 1.19e-151: 453: 100.00
+	Hs
		523904 XRCC6_HUMAN (3-609): 3.61e-141: 429: 14.49		DDB2_HUMAN (201-625): 1.38e-70: 236: 21.51
+	Hs
		523645 XRCC6_HUMAN (3-609): 3.61e-141: 429: 14.49		WDR5_HUMAN (435-622): 2.2e-42: 157: 12.23
+	Sc
		979564 KU80_YEAST (8-622): 1.51e-99: 321: 14.03		CMR1_YEAST (159-623): 1.38e-74: 249: 23.50
+	Sc
		698532 KU70_YEAST (8-541): 5.97e-92: 300: 16.73		CMR1_YEAST (159-623): 1.38e-74: 249: 23.50
+	Hs
		523698 XRCC6_HUMAN (3-609): 3.61e-141: 429: 14.49		RBBP4_HUMAN (233-477): 2.84e-19: 92.6: 14.55