Interactor 1: XRCC5 (P13010)
X-ray repair cross-complementing protein 5 (EC 3.6.4.-) (86 kDa subunit of Ku antigen) (ATP-dependent DNA helicase 2 subunit 2) (ATP-dependent DNA helicase II 80 kDa subunit) (CTC box-binding factor 85 kDa subunit) (CTC85) (CTCBF) (DNA repair protein XRCC5) (Ku80) (Ku86) (Lupus Ku autoantigen protein p86) (Nuclear factor IV) (Thyroid-lupus autoantigen) (TLAA) (X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining))
Gene: XRCC5

Interactor 2: NHEJ1 (Q9H9Q4)
Non-homologous end-joining factor 1 (Protein cernunnos) (XRCC4-like factor)
Gene: NHEJ1

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.79 1.00 0.892

The method score is based on:

Property Details
Experiments 26774286, 30017584, 31548606, 18064046, 21349273
Identification Methods affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains Ku_N~XLF
Common GO terms GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005958 - DNA-dependent protein kinase-DNA ligase 4 complex
GO:0006303 - double-strand break repair via nonhomologous end joining
GO:0045027 - DNA end binding
and 1 others

more...

Homologous interactions 1

Homologous interactions

Color coding for hit scores

1 732
Hs

1 299
+ Hs

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Last updated: 15 Jul 2024