Protein: WDR59
Maintenance of telomere capping protein 5 (SEH-associated protein 3)

Gene: WDR59, MTC5
Organism: Saccharomyces cerevisiae S288C
Interactions: 82
UniProt ID: Q03897

Gene Ontology (top 5):
GO:0000329 - fungal-type vacuole membrane
GO:0005774 - vacuolar membrane
GO:0015031 - protein transport
GO:0034198 - cellular response to amino acid starvation
GO:0035591 - signaling adaptor activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

814932

NPR2
Nitrogen permease regulator 2

4

6

Small-scale

0.890

High

916424

SEH1
Nucleoporin SEH1

4

20

Small-scale

0.890

High

1044261

SEC13
Protein transport protein SEC13

4

20

Small-scale

0.885

High

794724

SEA4
SEH-associated protein 4

3

6

Small-scale

0.834

High

866244

IML1
Vacuolar membrane-associated protein IML1

3

12

Small-scale

0.834

High

1044264

RTC1
Restriction of telomere capping protein 1

3

20

Small-scale

0.834

High

626874

HSP60
Heat shock protein 60, mitochondrial

2

20

High-throughput

0.675

High

803217

NPR3
Nitrogen permease regulator 3

3

1

Small-scale

0.646

High

811151

TCPZ
T-complex protein 1 subunit zeta

1

20

High-throughput

0.618

High

481751

HSP73
Heat shock protein SSA3

3

20

High-throughput

0.593

High

592478

VATB
V-type proton ATPase subunit B

2

11

High-throughput

0.584

High

865058

TCPQ
T-complex protein 1 subunit theta

1

20

High-throughput

0.578

High

1035066

UBC7
Ubiquitin-conjugating enzyme E2 7

1

8

High-throughput

0.528

High

680026

CDC48
Cell division control protein 48

2

9

High-throughput

0.521

High

1044267

CRM2
Homeostatic regulator of DAG

1

7

High-throughput

0.515

High

948642

ACT
Actin

1

9

High-throughput

0.514

High

510788

HSP77
Import motor subunit, mitochondrial

2

20

High-throughput

0.504

High

448792

SNF1
Carbon catabolite-derepressing protein kinase

1

7

High-throughput

0.500

High

453996

IF4E
Eukaryotic translation initiation factor 4E

1

4

High-throughput

0.489

High

560758

KIN2
Serine/threonine-protein kinase KIN2

1

7

High-throughput

0.489

High

567706

ACOX
Acyl-coenzyme A oxidase

1

3

High-throughput

0.489

High

642459

MCK1
Protein kinase MCK1

1

7

High-throughput

0.489

High

763491

MDJ1
DnaJ homolog 1, mitochondrial

1

14

High-throughput

0.489

High

801813

YHJ3
Uncharacterized protein YHR033W

1

4

High-throughput

0.489

High

922684

PPID
Peptidyl-prolyl cis-trans isomerase CPR6

1

3

High-throughput

0.489

High

1044260

KU80
ATP-dependent DNA helicase II subunit 2

1

3

High-throughput

0.489

High

1044263

VAM6
Vacuolar morphogenesis protein 6

1

2

High-throughput

0.479

High

359525

G3P1
Glyceraldehyde-3-phosphate dehydrogenase 1

1

11

High-throughput

0.457

High

367806

ENO1
Enolase 1

1

5

High-throughput

0.457

High

393267

HSP82
ATP-dependent molecular chaperone HSP82

1

20

High-throughput

0.457

High

405136

LEU3
3-isopropylmalate dehydrogenase

1

11

High-throughput

0.457

High

408342

GAL1
Galactokinase

1

4

High-throughput

0.457

High

408585

GAL10
Bifunctional protein GAL10 [Includes: UDP-glucose 4-epimerase

1

2

High-throughput

0.457

High

425144

OTC
Ornithine carbamoyltransferase

1

6

High-throughput

0.457

High

456451

ILVB
Acetolactate synthase catalytic subunit, mitochondrial

1

5

High-throughput

0.457

High

470040

GAL7
Galactose-1-phosphate uridylyltransferase

1

1

High-throughput

0.457

High

575513

GFA1
Glutamine--fructose-6-phosphate aminotransferase [isomerizing]

1

5

High-throughput

0.457

High

590710

HSP26
Heat shock protein 26

1

4

High-throughput

0.457

High

645774

HSP74
Heat shock protein SSA4

1

20

High-throughput

0.457

High

734195

EF2
Elongation factor 2

1

10

High-throughput

0.457

High

750890

PRS6B
26S proteasome regulatory subunit 6B homolog

1

14

High-throughput

0.457

High

856560

ALDH4
Potassium-activated aldehyde dehydrogenase, mitochondrial

1

9

High-throughput

0.457

High

1044268

HSP42
Heat shock protein 42

1

5

High-throughput

0.457

High

527580

HSP72
Heat shock protein SSA2

1

20

High-throughput

0.445

High

603541

VATA
V-type proton ATPase catalytic subunit A

1

13

High-throughput

0.445

High

557762

SRS2
ATP-dependent DNA helicase SRS2

1

4

Small-scale

0.439

High

741096

PUB1
Nuclear and cytoplasmic polyadenylated RNA-binding protein PUB1

1

3

High-throughput

0.437

High

802801

OSH3
Oxysterol-binding protein homolog 3

1

2

High-throughput

0.437

High

865739

MOG1
Nuclear import protein MOG1

1

1

High-throughput

0.437

High

1036919

MLP1
Protein MLP1

1

20

High-throughput

0.437

High

1044259

SCC2
Sister chromatid cohesion protein 2

1

1

High-throughput

0.437

High

792934

ANM1
Protein arginine N-methyltransferase 1

1

9

High-throughput

0.417

High

367109

ATPB
ATP synthase subunit beta, mitochondrial

1

10

High-throughput

0.407

High

368742

PMG1
Phosphoglycerate mutase 1

1

1

High-throughput

0.407

High

452529

PUR2
Bifunctional purine biosynthetic protein ADE5,7 [Includes: Phosphoribosylamine--glycine ligase

1

1

High-throughput

0.407

High

452962

ATPA
ATP synthase subunit alpha, mitochondrial

1

11

High-throughput

0.407

High

453772

PYR1
Multifunctional protein URA2

1

12

High-throughput

0.407

High

546130

SSB1
Ribosome-associated molecular chaperone SSB1

1

20

High-throughput

0.407

High

598909

PFKA1
ATP-dependent 6-phosphofructokinase subunit alpha

1

8

High-throughput

0.407

High

599067

PFKA2
ATP-dependent 6-phosphofructokinase subunit beta

1

8

High-throughput

0.407

High

644832

CLH
Clathrin heavy chain

1

9

High-throughput

0.407

High

661685

MPCP
Mitochondrial phosphate carrier protein

1

18

High-throughput

0.407

High

816382

HSP7E
Heat shock protein SSC3, mitochondrial

1

20

High-throughput

0.407

High

819686

SSB2
Ribosome-associated molecular chaperone SSB2

1

20

High-throughput

0.407

High

836023

COPB
Coatomer subunit beta

1

9

High-throughput

0.407

High

918673

PIL1
Sphingolipid long chain base-responsive protein PIL1

1

2

High-throughput

0.407

High

926276

ALDH6
Magnesium-activated aldehyde dehydrogenase, cytosolic

1

9

High-throughput

0.407

High

1044266

CWC2
Pre-mRNA-splicing factor CWC2

1

2

High-throughput

0.407

High

1044269

NOP58
Nucleolar protein 58

1

9

High-throughput

0.407

High

673125

RNQ1
[PIN+] prion protein RNQ1

1

0

High-throughput

0.279

Low

688817

RFA3
Replication factor A protein 3

1

0

High-throughput

0.279

Low

818644

FMP10
Uncharacterized mitochondrial membrane protein FMP10

1

0

High-throughput

0.279

Low

1044265

THI21
Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase THI21

1

0

High-throughput

0.279

Low

506514

YL016
Putative truncated guanine nucleotide exchange factor SDC25

1

0

High-throughput

0.261

Low

548297

FUS1
Nuclear fusion protein FUS1

1

0

High-throughput

0.261

Low

1044262

SOV1
Protein SOV1, mitochondrial

1

0

High-throughput

0.261

Low

697337

COQ8
Atypical kinase COQ8, mitochondrial

1

0

High-throughput

0.249

Low

807841

SSN2
Mediator of RNA polymerase II transcription subunit 13

1

0

Small-scale

0.249

Low

919087

SHY1
Cytochrome oxidase assembly protein SHY1

1

0

Small-scale

0.249

Low

1044258

MTQ2
eRF1 methyltransferase catalytic subunit MTQ2

1

0

High-throughput

0.249

Low

780637

CAB3
Coenzyme A biosynthesis protein 3

1

0

High-throughput

0.232

Low

828314

MKT1
Post-transcriptional regulator MKT1

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025