HitPredict

Interactor 1: CCL5 (P13501)
C-C motif chemokine 5 (EoCP) (Eosinophil chemotactic cytokine) (SIS-delta) (Small-inducible cytokine A5) (T cell-specific protein P228) (TCP228) (T-cell-specific protein RANTES) [Cleaved into: RANTES(3-68); RANTES(4-68)]
Gene: CCL5

Interactor 2: TF65 (Q04206)
Transcription factor p65 (Nuclear factor NF-kappa-B p65 subunit) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells 3)
Gene: RELA

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.78	0.60	0.688

Property	Details
Experiments	21988832, 16931600, 12820969, 22030901
Identification Methods	two hybrid, anti tag coimmunoprecipitation, two hybrid array
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0006954 - inflammatory response GO:0042803 - protein homodimerization activity GO:0071347 - cellular response to interleukin-1 GO:0071356 - cellular response to tumor necrosis factor
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 91 Hs			1 551
+	Hs
		526567 CCL4_HUMAN (1-91): 1.04e-35: 118: 45.65		TF65_HUMAN (1-551): 0: 601: 100.00
+	Hs
		978774 CCL14_HUMAN (1-91): 1.73e-33: 112: 34.41		TF65_HUMAN (1-551): 0: 601: 100.00
+	Hs
		528216 CCL2_HUMAN (1-90): 2.17e-27: 97.3: 33.70		TF65_HUMAN (1-551): 0: 601: 100.00
+	Mm
		677067 CCL5_MOUSE (1-91): 1.06e-35: 118: 80.22		TF65_MOUSE (1-551): 0: 577: 87.88
+	Hs
		943970 X3CL1_HUMAN (7-90): 2.46e-22: 90.4: 22.73		TF65_HUMAN (1-551): 0: 601: 100.00
+	Mm
		486360 CCL2_MOUSE (1-91): 7.78e-33: 112: 31.18		TF65_MOUSE (1-551): 0: 577: 87.88
+	Hs
		134732 CCL22_HUMAN (22-90): 6.56e-22: 83: 32.39		TF65_HUMAN (1-551): 0: 601: 100.00
+	Mm
		638438 CCL5_MOUSE (1-91): 1.06e-35: 118: 80.22		NFKB1_MOUSE (7-451): 3.1e-157: 475: 30.19
+	Hs
		528261 CCL5_HUMAN (1-91): 4.43e-31: 106: 100.00		REL_HUMAN (12-523): 3.56e-165: 484: 41.64
+	Mm
		486356 CCL2_MOUSE (1-91): 7.78e-33: 112: 31.18		NFKB1_MOUSE (7-451): 3.1e-157: 475: 30.19
+	Hs
		587597 CCL14_HUMAN (1-91): 1.73e-33: 112: 34.41		NFKB1_HUMAN (7-451): 2.23e-153: 465: 29.51
+	Hs
		587476 CCL11_HUMAN (1-90): 8.16e-28: 98.1: 41.76		NFKB1_HUMAN (7-451): 2.23e-153: 465: 29.51
+	Hs
		528199 CCL2_HUMAN (1-90): 2.17e-27: 97.3: 33.70		NFKB1_HUMAN (7-451): 2.23e-153: 465: 29.51
+	Hs
		528259 CCL5_HUMAN (1-91): 4.43e-31: 106: 100.00		RELB_HUMAN (3-461): 2.62e-154: 455: 40.00
+	Hs
		134722 CCL22_HUMAN (22-90): 6.56e-22: 83: 32.39		NFKB1_HUMAN (7-451): 2.23e-153: 465: 29.51
+	Hs
		587691 CCL19_HUMAN (17-91): 9.87e-22: 83: 31.17		NFKB1_HUMAN (7-451): 2.23e-153: 465: 29.51
+	Hs
		964508 CCL17_HUMAN (1-89): 3.41e-23: 86.5: 28.09		RELB_HUMAN (3-461): 2.62e-154: 455: 40.00
+	Hs
		134731 CCL22_HUMAN (22-90): 6.56e-22: 83: 32.39		RELB_HUMAN (3-461): 2.62e-154: 455: 40.00
+	Hs
		961427 CCL19_HUMAN (17-91): 9.87e-22: 83: 31.17		NFKB2_HUMAN (7-409): 7.21e-137: 420: 34.75
+	Mm
		486364 CCL2_MOUSE (1-91): 7.78e-33: 112: 31.18		NFAT5_MOUSE (6-471): 3.35e-100: 333: 17.26