Protein: INSRR
Insulin receptor-related protein (IRR) (EC 2.7.10.1) (IR-related receptor) [Cleaved into: Insulin receptor-related protein alpha chain; Insulin receptor-related protein beta chain]

Gene: INSRR
Organism: Homo sapiens
Interactions: 87
UniProt ID: P14616

Gene Ontology (top 5):
GO:0004714 - transmembrane receptor protein tyrosine kinase activity
GO:0005009 - insulin receptor activity
GO:0005524 - ATP binding
GO:0005886 - plasma membrane
GO:0005899 - insulin receptor complex

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

439630

INSR
Insulin receptor

3

18

Small-scale

0.867

High

461098

HS90A
Heat shock protein HSP 90-alpha

3

20

High-throughput

0.861

High

468023

HS90B
Heat shock protein HSP 90-beta

3

20

High-throughput

0.861

High

465392

IGF1R
Insulin-like growth factor 1 receptor

2

18

High-throughput

0.811

High

410576

ERBB2
Receptor tyrosine-protein kinase erbB-2

2

20

Small-scale

0.793

High

572904

UFO
Tyrosine-protein kinase receptor UFO

2

20

High-throughput

0.789

High

572928

CDC37
Hsp90 co-chaperone Cdc37

2

20

High-throughput

0.726

High

572899

KPCA
Protein kinase C alpha type

1

17

High-throughput

0.691

High

572900

PTN1
Tyrosine-protein phosphatase non-receptor type 1

1

20

High-throughput

0.691

High

572902

JAK1
Tyrosine-protein kinase JAK1

1

20

High-throughput

0.691

High

572905

BMR1A
Bone morphogenetic protein receptor type-1A

1

20

High-throughput

0.691

High

572906

ACV1B
Activin receptor type-1B

1

20

High-throughput

0.691

High

572912

RAB13
Ras-related protein Rab-13

1

14

High-throughput

0.691

High

572917

ACVR1
Activin receptor type-1

1

20

High-throughput

0.691

High

572918

KPCD
Protein kinase C delta type

1

18

High-throughput

0.691

High

572920

DDR1
Epithelial discoidin domain-containing receptor 1

1

19

High-throughput

0.691

High

572933

VASN
Vasorin

1

20

High-throughput

0.691

High

572940

VRK2
Serine/threonine-protein kinase VRK2

1

20

High-throughput

0.691

High

572946

ARH40
Rho guanine nucleotide exchange factor 40

1

20

High-throughput

0.691

High

572953

PMYT1
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase

1

15

High-throughput

0.691

High

572947

STYX
Serine/threonine/tyrosine-interacting protein

1

20

High-throughput

0.625

High

572921

FKBP5
Peptidyl-prolyl cis-trans isomerase FKBP5

1

20

High-throughput

0.618

High

572925

FKBP8
Peptidyl-prolyl cis-trans isomerase FKBP8

1

18

High-throughput

0.618

High

572927

RBBP5
Retinoblastoma-binding protein 5

1

7

High-throughput

0.618

High

572956

OSBL8
Oxysterol-binding protein-related protein 8

1

20

High-throughput

0.618

High

572957

OSBL5
Oxysterol-binding protein-related protein 5

1

20

High-throughput

0.618

High

136280

P85B
Phosphatidylinositol 3-kinase regulatory subunit beta

1

20

High-throughput

0.618

High

572903

EPHA8
Ephrin type-A receptor 8

1

20

High-throughput

0.618

High

572914

GRB2
Growth factor receptor-bound protein 2

1

20

High-throughput

0.618

High

572922

TBB3
Tubulin beta-3 chain

1

20

High-throughput

0.618

High

572931

HS905
Putative heat shock protein HSP 90-alpha A5

1

20

High-throughput

0.575

High

572955

GRWD1
Glutamate-rich WD repeat-containing protein 1

1

7

High-throughput

0.553

High

572907

SRBP1
Sterol regulatory element-binding protein 1

1

15

High-throughput

0.536

High

572916

TAP1
Antigen peptide transporter 1

1

8

High-throughput

0.536

High

572935

S27A4
Long-chain fatty acid transport protein 4

1

4

High-throughput

0.536

High

572936

RHDF2
Inactive rhomboid protein 2

1

1

High-throughput

0.536

High

572943

PLCD3
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3

1

20

High-throughput

0.536

High

572952

MYADM
Myeloid-associated differentiation marker

1

2

High-throughput

0.536

High

572944

EMC5
ER membrane protein complex subunit 5

1

0

High-throughput

0.513

High

572948

DCAKD
Dephospho-CoA kinase domain-containing protein

1

0

High-throughput

0.513

High

227783

MYO1B
Unconventional myosin-Ib

1

20

High-throughput

0.500

High

318255

MYO1D
Unconventional myosin-Id

1

18

High-throughput

0.500

High

572962

GBG12

1

3

High-throughput

0.500

High

158548

CTDS2
Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2

1

6

High-throughput

0.494

High

175830

SET1A
Histone-lysine N-methyltransferase SETD1A

1

4

High-throughput

0.489

High

572909

IDHP
Isocitrate dehydrogenase [NADP], mitochondrial

1

2

High-throughput

0.489

High

572924

ZMYM3
Zinc finger MYM-type protein 3

1

2

High-throughput

0.489

High

572929

CP51A
Lanosterol 14-alpha demethylase

1

5

High-throughput

0.489

High

572932

CDKAL
Threonylcarbamoyladenosine tRNA methylthiotransferase

1

8

High-throughput

0.489

High

572939

ANKL2
Ankyrin repeat and LEM domain-containing protein 2

1

6

High-throughput

0.489

High

572950

VCIP1
Deubiquitinating protein VCPIP1

1

1

High-throughput

0.489

High

572958

TYW1
S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase TYW1

1

2

High-throughput

0.489

High

572961

CXXC1
CXXC-type zinc finger protein 1

1

2

High-throughput

0.489

High

572963

ASH2L
Set1/Ash2 histone methyltransferase complex subunit ASH2

1

7

High-throughput

0.489

High

572964

DJB11
DnaJ homolog subfamily B member 11

1

20

High-throughput

0.489

High

572965

MAN1
Inner nuclear membrane protein Man1

1

11

High-throughput

0.489

High

332850

VAPB
Vesicle-associated membrane protein-associated protein B/C

1

20

High-throughput

0.479

High

424126

S10A8
Protein S100-A8

1

9

High-throughput

0.479

High

572901

ARF4
ADP-ribosylation factor 4

1

18

High-throughput

0.479

High

572919

CKAP4
Cytoskeleton-associated protein 4

1

20

High-throughput

0.479

High

572923

STIM1
Stromal interaction molecule 1

1

18

High-throughput

0.479

High

572926

DSC3
Desmocollin-3

1

20

High-throughput

0.479

High

572954

CHP1
Calcineurin B homologous protein 1

1

3

High-throughput

0.479

High

572959

DDX56
Probable ATP-dependent RNA helicase DDX56

1

12

High-throughput

0.479

High

572934

Q6FHY5
MEOX2 protein

1

3

High-throughput

0.470

High

572908

HUTH
Histidine ammonia-lyase

1

1

High-throughput

0.457

High

572910

MEOX2
Homeobox protein MOX-2

1

3

High-throughput

0.439

High

74432

HNRC2
Heterogeneous nuclear ribonucleoprotein C-like 2

1

12

High-throughput

0.437

High

124730

AIP
AH receptor-interacting protein

1

14

High-throughput

0.437

High

280995

TACC1
Transforming acidic coiled-coil-containing protein 1

1

20

High-throughput

0.437

High

468981

SRPRA
Signal recognition particle receptor subunit alpha

1

12

High-throughput

0.437

High

572911

EMD
Emerin

1

10

High-throughput

0.437

High

572913

AL3A2
Aldehyde dehydrogenase family 3 member A2

1

14

High-throughput

0.437

High

572915

KRT83
Keratin, type II cuticular Hb3

1

2

High-throughput

0.437

High

572937

LYRIC
Protein LYRIC

1

4

High-throughput

0.437

High

572941

LRC49
Leucine-rich repeat-containing protein 49

1

20

High-throughput

0.437

High

572942

DJC10
DnaJ homolog subfamily C member 10

1

20

High-throughput

0.437

High

572945

TXND5
Thioredoxin domain-containing protein 5

1

20

High-throughput

0.437

High

572951

CLCC1
Chloride channel CLIC-like protein 1

1

10

High-throughput

0.437

High

572960

NOP53
Ribosome biogenesis protein NOP53

1

1

High-throughput

0.437

High

572966

RT23
Small ribosomal subunit protein mS23

1

1

High-throughput

0.437

High

572967

SRPRB
Signal recognition particle receptor subunit beta

1

20

High-throughput

0.437

High

399659

HMDH
3-hydroxy-3-methylglutaryl-coenzyme A reductase

1

0

High-throughput

0.279

Low

572930

DB116
Beta-defensin 116

1

0

High-throughput

0.279

Low

572938

T200A
Transmembrane protein 200A

1

0

High-throughput

0.279

Low

572949

OTUL
Ubiquitin thioesterase otulin

1

0

High-throughput

0.279

Low

338041

NSA2
Ribosome biogenesis protein NSA2 homolog

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025