HitPredict

Interactor 1: CFTR (P13569)
Cystic fibrosis transmembrane conductance regulator (CFTR) (ATP-binding cassette sub-family C member 7) (Channel conductance-controlling ATPase) (EC 5.6.1.6) (cAMP-dependent chloride channel)
Gene: CFTR

Interactor 2: AT2B4 (P23634)
Plasma membrane calcium-transporting ATPase 4 (PMCA4) (EC 7.2.2.10) (Matrix-remodeling-associated protein 1) (Plasma membrane calcium ATPase isoform 4) (Plasma membrane calcium pump isoform 4)
Gene: ATP2B4

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	26618866
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005524 - ATP binding GO:0005886 - plasma membrane GO:0016020 - membrane GO:0016887 - ATP hydrolysis activity GO:0030165 - PDZ domain binding and 1 others more... GO:0032991 - protein-containing complex
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 1480 Hs			1 1241
+	Hs
		528523 CFTR_HUMAN (1-1480): 0: 1031: 100.00		AT2B1_HUMAN (1-1241): 0: 1148: 72.46
+	Hs
		528795 CFTR_HUMAN (1-1480): 0: 1031: 100.00		AT1A2_HUMAN (35-1053): 0: 753: 23.60
+	Hs
		393007 CFTR_HUMAN (1-1480): 0: 1031: 100.00		AT1A1_HUMAN (34-1053): 0: 737: 23.37
+	Hs
		528489 CFTR_HUMAN (1-1480): 0: 1031: 100.00		AT2A2_HUMAN (45-1066): 0: 733: 25.98
+	Hs
		529516 CFTR_HUMAN (1-1480): 0: 1031: 100.00		AT2A3_HUMAN (46-1060): 0: 733: 24.89
+	Hs
		179351 MRP4_HUMAN (5-647): 2.25e-59: 227: 15.67		AT2B2_HUMAN (3-1241): 0: 1154: 68.59
+	Dm
		1123741 Q7KTD0_DROME (788-1466): 6.87e-53: 206: 14.95		Q59DP8_DROME (16-1104): 0: 1017: 62.80