Protein: ERG25
C-4 methylsterol oxidase ERG25 (EC 1.14.18.-) (Ergosterol biosynthetic protein 25) (Sterol-C4-methyl oxidase ERG25) (SMO)

Gene: ERG25
Organism: Saccharomyces cerevisiae S288C
Interactions: 116
UniProt ID: P53045

Gene Ontology (top 5):
GO:0000254 - C-4 methylsterol oxidase activity
GO:0005506 - iron ion binding
GO:0005789 - endoplasmic reticulum membrane
GO:0005886 - plasma membrane
GO:0006696 - ergosterol biosynthetic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

916791

ERG27
3-keto-steroid reductase ERG27

3

1

Small-scale

0.680

High

817334

ERG28
Ergosterol biosynthetic protein 28

3

2

Small-scale

0.678

High

797005

PHO88
SRP-independent targeting protein 3

3

2

High-throughput

0.669

High

916767

ERG26
Sterol-4-alpha-carboxylate 3-dehydrogenase ERG26, decarboxylating

3

2

Small-scale

0.660

High

528612

CP51
Lanosterol 14-alpha demethylase CYP51

2

3

Small-scale

0.632

High

735349

ERG3
Delta(7)-sterol 5(6)-desaturase ERG3

2

4

Small-scale

0.632

High

737578

ERG1
Squalene epoxidase ERG1

2

1

Small-scale

0.632

High

916777

GSF2
Glucose-signaling factor 2

2

2

High-throughput

0.614

High

916764

ERG25
C-4 methylsterol oxidase ERG25

2

4

Small-scale

0.613

High

823160

ALG5
Dolichyl-phosphate beta-glucosyltransferase

2

0

High-throughput

0.605

High

863215

PHO86
Inorganic phosphate transporter PHO86

2

1

High-throughput

0.577

High

524580

HSP71
Heat shock protein SSA1

2

5

High-throughput

0.571

High

545583

SSB1
Ribosome-associated molecular chaperone SSB1

2

4

High-throughput

0.571

High

687067

PPZ1
Serine/threonine-protein phosphatase PP-Z1

2

2

High-throughput

0.559

High

470078

PSS
CDP-diacylglycerol--serine O-phosphatidyltransferase

1

1

High-throughput

0.541

High

668935

ERG6
Sterol 24-C-methyltransferase ERG6

1

1

Small-scale

0.541

High

672164

ERG4
Delta(24(24(1)))-sterol reductase ERG4

1

1

Small-scale

0.541

High

672823

ELO2
Fatty acid elongase 2

1

6

High-throughput

0.541

High

673437

AGP1
General amino acid permease AGP1

1

3

High-throughput

0.541

High

703838

LAC1
Ceramide synthase LAC1

1

1

High-throughput

0.541

High

715042

ERG9
Squalene synthase ERG9

1

1

Small-scale

0.541

High

745370

EMP24
Endosomal protein P24B

1

3

High-throughput

0.541

High

776380

YET1
Endoplasmic reticulum transmembrane protein 1

1

1

High-throughput

0.541

High

780459

SRPB
Signal recognition particle receptor subunit beta

1

2

High-throughput

0.541

High

797424

MKAR
Very-long-chain 3-oxoacyl-CoA reductase

1

2

High-throughput

0.541

High

798657

SSH1
Sec sixty-one protein homolog

1

1

High-throughput

0.541

High

799710

CUE1
Coupling of ubiquitin conjugation to ER degradation protein 1

1

1

High-throughput

0.541

High

800447

ERG7
Lanosterol synthase ERG7

1

1

Small-scale

0.541

High

802491

LAG1
Ceramide synthase LAG1

1

1

High-throughput

0.541

High

805898

YHU0
UPF0641 membrane protein YHR140W

1

1

High-throughput

0.541

High

812918

UIP3
ULP1-interacting protein 3

1

1

High-throughput

0.541

High

813600

ERP2
Protein ERP2

1

4

High-throughput

0.541

High

822321

ELO3
Fatty acid elongase 3

1

6

High-throughput

0.541

High

826259

SNL1
HSP70 co-chaperone SNL1

1

1

High-throughput

0.541

High

863267

GPI2
Phosphatidylinositol N-acetylglucosaminyltransferase GPI2 subunit

1

1

High-throughput

0.541

High

863332

SPC1
Signal peptidase complex subunit 1

1

1

High-throughput

0.541

High

916766

MST27
Multicopy suppressor of SEC21 protein 27

1

1

High-throughput

0.541

High

916770

ERG5
C-22 sterol desaturase ERG5

1

1

Small-scale

0.541

High

916771

TMEDA
Endoplasmic reticulum vesicle protein 25

1

6

High-throughput

0.541

High

916772

SHR3
Secretory component protein SHR3

1

1

High-throughput

0.541

High

916773

GAS3
Probable 1,3-beta-glucanosyltransferase GAS3

1

1

High-throughput

0.541

High

916779

ERP1
Protein ERP1

1

6

High-throughput

0.541

High

916780

GAS2
1,3-beta-glucanosyltransferase GAS2

1

1

High-throughput

0.541

High

916781

ORM2
Protein ORM2

1

2

High-throughput

0.541

High

916783

SPO75
Sporulation-specific protein 75

1

2

High-throughput

0.541

High

916784

TPO1
Polyamine transporter 1

1

3

High-throughput

0.541

High

916787

PFA4
Palmitoyltransferase PFA4

1

1

High-throughput

0.541

High

916790

ERP4
Protein ERP4

1

6

High-throughput

0.541

High

554366

HMDH1
3-hydroxy-3-methylglutaryl-coenzyme A reductase 1

1

0

High-throughput

0.518

High

554472

TRK1
High-affinity potassium transport protein

1

0

High-throughput

0.518

High

613867

ERD2
ER lumen protein-retaining receptor

1

0

High-throughput

0.518

High

735318

ERG2
C-8 sterol isomerase ERG2

1

0

Small-scale

0.518

High

797608

YPC1
Alkaline ceramidase YPC1

1

0

High-throughput

0.518

High

808967

HXT6
High-affinity hexose transporter HXT6

1

0

High-throughput

0.518

High

820861

ERG29
Ergosterol biosynthesis protein 29

1

0

High-throughput

0.518

High

830039

PMP2
Plasma membrane ATPase proteolipid 2

1

0

High-throughput

0.518

High

835927

VMA21
Vacuolar ATPase assembly integral membrane protein VMA21

1

0

High-throughput

0.518

High

866114

STE24
CAAX prenyl protease 1

1

0

High-throughput

0.518

High

866129

ILM1
Protein ILM1

1

0

High-throughput

0.518

High

916768

ERV29
ER-derived vesicles protein ERV29

1

0

High-throughput

0.518

High

916778

SPC2
Signal peptidase complex subunit 2

1

0

High-throughput

0.518

High

916789

YOP1
Protein YOP1

1

0

High-throughput

0.518

High

916792

TECR
Very-long-chain enoyl-CoA reductase

1

0

High-throughput

0.518

High

748469

SC61A
Protein transport protein SEC61

1

1

High-throughput

0.494

High

794154

YB91
Probable metabolite transport protein YBR241C

1

1

High-throughput

0.494

High

836162

BAP3
Valine amino-acid permease

1

3

High-throughput

0.494

High

916786

YP264
Probable transport protein YPL264C

1

1

High-throughput

0.494

High

822192

CYB5
Cytochrome b5

1

5

High-throughput

0.479

High

916793

ENV10
SRP-independent targeting protein 2

1

2

High-throughput

0.479

High

506206

AQY1
Aquaporin-1

1

0

High-throughput

0.460

High

365661

PGK
Phosphoglycerate kinase

1

0

High-throughput

0.458

High

636335

ACO1
Acyl-CoA desaturase 1

1

0

High-throughput

0.458

High

816205

SPF1
Endoplasmic reticulum transmembrane helix translocase

1

0

High-throughput

0.458

High

527194

HSP72
Heat shock protein SSA2

1

5

High-throughput

0.445

High

679882

CDC48
Cell division control protein 48

1

1

High-throughput

0.445

High

751102

PDR5
Pleiotropic ABC efflux transporter of multiple drugs

1

2

High-throughput

0.445

High

819276

SSB2
Ribosome-associated molecular chaperone SSB2

1

4

High-throughput

0.445

High

916769

COPA
Coatomer subunit alpha

1

1

High-throughput

0.437

High

916776

DHR1
Probable ATP-dependent RNA helicase DHR1

1

1

High-throughput

0.437

High

801080

FKS1
1,3-beta-glucan synthase component FKS1

1

0

High-throughput

0.426

High

893400

MNN10
Probable alpha-1,6-mannosyltransferase MNN10

1

0

High-throughput

0.426

High

916775

USA1
U1 SNP1-associating protein 1

1

0

High-throughput

0.426

High

386792

TBB
Tubulin beta chain

1

1

High-throughput

0.407

High

394735

EF1A
Elongation factor 1-alpha

1

1

High-throughput

0.407

High

427364

RLA0
Large ribosomal subunit protein uL10

1

1

High-throughput

0.407

High

486257

TBA1
Tubulin alpha-1 chain

1

1

High-throughput

0.407

High

531810

RL4A
Large ribosomal subunit protein uL4A

1

1

High-throughput

0.407

High

592374

VATB
V-type proton ATPase subunit B

1

1

High-throughput

0.407

High

626817

HSP60
Heat shock protein 60, mitochondrial

1

1

High-throughput

0.407

High

796102

IMB2
Importin subunit beta-2

1

1

High-throughput

0.407

High

817911

IMB4
Importin subunit beta-4

1

1

High-throughput

0.407

High

835838

RL10
Large ribosomal subunit protein uL16

1

1

High-throughput

0.407

High

598520

ALG1
Chitobiosyldiphosphodolichol beta-mannosyltransferase

1

0

High-throughput

0.282

High

645115

EPT1
Choline/ethanolaminephosphotransferase 1

1

0

High-throughput

0.282

High

782620

TVP38
Golgi apparatus membrane protein TVP38

1

0

High-throughput

0.282

High

826140

EMC5
ER membrane protein complex subunit 5

1

0

High-throughput

0.282

High

898920

AVT4
Vacuolar amino acid transporter 4

1

0

High-throughput

0.282

High

916788

RBD2
Rhomboid-type serine protease 2

1

0

High-throughput

0.282

High

570280

RS17B
Small ribosomal subunit protein eS17B

1

0

High-throughput

0.249

Low

661543

PSA2
Proteasome subunit alpha type-2

1

0

High-throughput

0.249

Low

677483

KRR1
KRR1 small subunit processome component

1

0

High-throughput

0.249

Low

812490

LAA1
AP-1 accessory protein LAA1

1

0

High-throughput

0.249

Low

916782

VAM6
Vacuolar morphogenesis protein 6

1

0

High-throughput

0.249

Low

822228

SECU
Securin

1

0

High-throughput

0.238

Low

916785

RBX1
RING-box protein HRT1

1

0

High-throughput

0.238

Low

452523

PUR2
Bifunctional purine biosynthetic protein ADE5,7 [Includes: Phosphoribosylamine--glycine ligase

1

0

High-throughput

0.232

Low

453693

PYR1
Multifunctional protein URA2

1

0

High-throughput

0.232

Low

661664

MPCP
Mitochondrial phosphate carrier protein

1

0

High-throughput

0.232

Low

712618

RL8B
Large ribosomal subunit protein eL8B

1

0

High-throughput

0.232

Low

802660

YHI0
Putative proline--tRNA ligase YHR020W

1

0

High-throughput

0.232

Low

803623

RPN1
26S proteasome regulatory subunit RPN1

1

0

High-throughput

0.232

Low

816594

GEA2
ARF guanine-nucleotide exchange factor 2

1

0

High-throughput

0.232

Low

836792

MPG1
Mannose-1-phosphate guanyltransferase

1

0

High-throughput

0.232

Low

916765

DXO
Decapping nuclease RAI1

1

0

High-throughput

0.232

Low

916774

CLU
Clustered mitochondria protein 1

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025