HitPredict

Interactor 1: CFTR (P13569)
Cystic fibrosis transmembrane conductance regulator (CFTR) (ATP-binding cassette sub-family C member 7) (Channel conductance-controlling ATPase) (EC 5.6.1.6) (cAMP-dependent chloride channel)
Gene: CFTR

Interactor 2: EIF3A (Q14152)
Eukaryotic translation initiation factor 3 subunit A (eIF3a) (Eukaryotic translation initiation factor 3 subunit 10) (eIF-3-theta) (eIF3 p167) (eIF3 p180) (eIF3 p185)
Gene: EIF3A

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.60	0.60	0.601

Property	Details
Experiments	26618866, 31324722
Identification Methods	affinity chromatography technology, cross-linking study, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0016020 - membrane
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 1480 Hs			1 1382
+	Hs
		528675 CFTR_HUMAN (1-1480): 0: 1031: 100.00		MYH9_HUMAN (55-1098): 6.44e-45: 180: 9.65
+	Hs
		528676 CFTR_HUMAN (1-1480): 0: 1031: 100.00		MYH10_HUMAN (46-929): 1.09e-34: 147: 10.53
+	Hs
		529896 CFTR_HUMAN (1-1480): 0: 1031: 100.00		MYH13_HUMAN (638-1382): 4.53e-29: 128: 8.77
+	Hs
		502902 CFTR_HUMAN (1-1480): 0: 1031: 100.00		MYH3_HUMAN (355-1375): 4.75e-28: 125: 9.20
+	Hs
		528682 CFTR_HUMAN (1-1480): 0: 1031: 100.00		MYH11_HUMAN (79-823): 1.69e-23: 110: 11.10
+	Hs
		529895 CFTR_HUMAN (1-1480): 0: 1031: 100.00		MYH2_HUMAN (36-853): 1.99e-23: 110: 10.32
+	Hs
		529972 CFTR_HUMAN (1-1480): 0: 1031: 100.00		MYH4_HUMAN (9-938): 3.72e-23: 109: 9.08
+	Hs
		528357 CFTR_HUMAN (1-1480): 0: 1031: 100.00		MYH6_HUMAN (366-1087): 4.95e-21: 102: 10.45
+	Hs
		528400 CFTR_HUMAN (1-1480): 0: 1031: 100.00		MYH8_HUMAN (849-1382): 9.44e-20: 98.5: 7.87
+	Hs
		529144 CFTR_HUMAN (1-1480): 0: 1031: 100.00		PLEC_HUMAN (497-1343): 1.73e-18: 94.5: 13.97
+	Hs
		522533 CFTR_HUMAN (1-1480): 0: 1031: 100.00		MYH1_HUMAN (83-1022): 3.5e-18: 93.2: 10.72
+	Hs
		522586 CFTR_HUMAN (1-1480): 0: 1031: 100.00		MYH7_HUMAN (83-989): 5.61e-18: 92.8: 10.62
+	Hs
		529968 CFTR_HUMAN (1-1480): 0: 1031: 100.00		MRCKB_HUMAN (610-1132): 1.14e-14: 82: 10.96
+	Hs
		529340 CFTR_HUMAN (1-1480): 0: 1031: 100.00		MYH14_HUMAN (488-1381): 1.41e-12: 75.1: 9.26
+	Hs
		528484 CFTR_HUMAN (1-1480): 0: 1031: 100.00		DESP_HUMAN (478-1060): 3.57e-11: 70.4: 13.18
+	Hs
		529495 CFTR_HUMAN (1-1480): 0: 1031: 100.00		MY18A_HUMAN (532-955): 1.34e-09: 65.3: 16.18