HitPredict

Interactor 1: NUAK1 (O60285)
NUAK family SNF1-like kinase 1 (EC 2.7.11.1) (AMPK-related protein kinase 5) (ARK5) (Omphalocele kinase 1)
Gene: NUAK1

Interactor 2: 1433E (P62258)
14-3-3 protein epsilon (14-3-3E)
Gene: YWHAE

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	36736316
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0035556 - intracellular signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 661 Hs			1 255
+	Mm
		910266 NUAK1_MOUSE (1-661): 0: 557: 90.79		1433E_MOUSE (1-255): 4.87e-154: 430: 100.00
+	Xl
		223344 Q804T2_XENLA (4-658): 1.2e-161: 483: 25.67		O57468_XENLA (1-255): 1.7e-152: 426: 96.47
+	Hs
		647862 MARK3_HUMAN (4-658): 1.17e-156: 471: 27.09		1433E_HUMAN (1-255): 4.87e-154: 430: 100.00
+	Mm
		910231 MARK3_MOUSE (4-658): 2.75e-156: 470: 27.09		1433E_MOUSE (1-255): 4.87e-154: 430: 100.00
+	Hs
		909916 MARK4_HUMAN (4-655): 1.51e-155: 468: 27.16		1433E_HUMAN (1-255): 4.87e-154: 430: 100.00
+	Mm
		910308 MARK4_MOUSE (4-655): 2.73e-155: 468: 27.01		1433E_MOUSE (1-255): 4.87e-154: 430: 100.00
+	Hs
		909730 MARK2_HUMAN (1-658): 9.28e-152: 460: 23.88		1433E_HUMAN (1-255): 4.87e-154: 430: 100.00
+	Mm
		910234 MARK2_MOUSE (1-658): 1.92e-150: 456: 23.55		1433E_MOUSE (1-255): 4.87e-154: 430: 100.00
+	Xl
		223345 Q8QGV3_XENLA (4-658): 6.08e-149: 452: 23.93		O57468_XENLA (1-255): 1.7e-152: 426: 96.47
+	Hs
		910009 NUAK2_HUMAN (1-661): 2.59e-148: 445: 49.92		1433E_HUMAN (1-255): 4.87e-154: 430: 100.00
+	Dm
		90534 E1JGN0_DROME (8-658): 2.11e-147: 458: 23.29		1433E_DROME (1-254): 2.95e-146: 411: 82.69
+	Hs
		910106 MARK1_HUMAN (4-658): 1.87e-140: 431: 24.32		1433E_HUMAN (1-255): 4.87e-154: 430: 100.00
+	Hs
		909532 KCC2D_HUMAN (50-557): 3.32e-142: 425: 23.55		1433E_HUMAN (1-255): 4.87e-154: 430: 100.00
+	Hs
		909567 MELK_HUMAN (50-654): 5.18e-140: 425: 24.39		1433E_HUMAN (1-255): 4.87e-154: 430: 100.00
+	At
		965360 CIPKC_ARATH (32-367): 3.8e-138: 414: 31.77		14332_ARATH (4-255): 1.05e-147: 414: 74.41
+	At
		788672 CIPKC_ARATH (32-367): 3.8e-138: 414: 31.77		14333_ARATH (1-253): 3.45e-147: 413: 74.12
+	At
		1280891 CIPKC_ARATH (32-367): 3.8e-138: 414: 31.77		14337_ARATH (2-255): 7.73e-147: 412: 71.21
+	Sc
		419854 SNF1_YEAST (55-509): 1.88e-132: 405: 29.98		BMH2_YEAST (4-242): 1.14e-134: 382: 77.08
+	Sc
		419824 SNF1_YEAST (55-509): 1.88e-132: 405: 29.98		BMH1_YEAST (2-243): 2.43e-134: 381: 75.72
+	Hs
		910187 SIK3_HUMAN (35-309): 9.42e-68: 243: 46.01		1433E_HUMAN (1-255): 4.87e-154: 430: 100.00