HitPredict

Interactor 1: CFTR (P13569)
Cystic fibrosis transmembrane conductance regulator (CFTR) (ATP-binding cassette sub-family C member 7) (Channel conductance-controlling ATPase) (EC 5.6.1.6) (cAMP-dependent chloride channel)
Gene: CFTR

Interactor 2: OPTN (Q96CV9)
Optineurin (E3-14.7K-interacting protein) (FIP-2) (Huntingtin yeast partner L) (Huntingtin-interacting protein 7) (HIP-7) (Huntingtin-interacting protein L) (NEMO-related protein) (Optic neuropathy-inducing protein) (Transcription factor IIIA-interacting protein) (TFIIIA-IntP)
Gene: OPTN

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.48	0.60	0.541

Property	Details
Experiments	35156780
Identification Methods	protein complementation assay, ubiquitin reconstruction
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0055038 - recycling endosome membrane
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 1480 Hs			1 577
+	Hs
		529102 CFTR_HUMAN (1-1480): 0: 1031: 100.00		DCTN1_HUMAN (199-553): 3.22e-27: 119: 17.58
+	Hs
		528484 CFTR_HUMAN (1-1480): 0: 1031: 100.00		DESP_HUMAN (6-522): 2.58e-16: 85.1: 11.60
+	Hs
		522586 CFTR_HUMAN (1-1480): 0: 1031: 100.00		MYH7_HUMAN (171-563): 8.39e-15: 80.3: 16.29
+	Hs
		529495 CFTR_HUMAN (1-1480): 0: 1031: 100.00		MY18A_HUMAN (73-548): 2.87e-14: 78.5: 12.99
+	Hs
		528676 CFTR_HUMAN (1-1480): 0: 1031: 100.00		MYH10_HUMAN (233-561): 3.51e-13: 74.9: 10.88
+	Hs
		529895 CFTR_HUMAN (1-1480): 0: 1031: 100.00		MYH2_HUMAN (226-567): 1.02e-12: 73.3: 11.82
+	Hs
		529767 CFTR_HUMAN (1-1480): 0: 1031: 100.00		MYO5C_HUMAN (39-462): 1.18e-12: 73.1: 14.87
+	Hs
		528357 CFTR_HUMAN (1-1480): 0: 1031: 100.00		MYH6_HUMAN (226-544): 5.47e-12: 71: 15.05
+	Hs
		522533 CFTR_HUMAN (1-1480): 0: 1031: 100.00		MYH1_HUMAN (226-567): 1.98e-11: 69.5: 11.82
+	Hs
		528682 CFTR_HUMAN (1-1480): 0: 1031: 100.00		MYH11_HUMAN (263-576): 6.07e-11: 67.9: 15.36
+	Hs
		528400 CFTR_HUMAN (1-1480): 0: 1031: 100.00		MYH8_HUMAN (226-544): 1.02e-10: 67.2: 12.85
+	Hs
		529972 CFTR_HUMAN (1-1480): 0: 1031: 100.00		MYH4_HUMAN (226-567): 2.08e-10: 66: 12.10
+	Hs
		528675 CFTR_HUMAN (1-1480): 0: 1031: 100.00		MYH9_HUMAN (171-574): 4.74e-10: 64.8: 13.08
+	Hs
		529968 CFTR_HUMAN (1-1480): 0: 1031: 100.00		MRCKB_HUMAN (39-409): 3.06e-09: 62.4: 14.77