Protein: SPG21
Maspardin (Acid cluster protein 33) (Spastic paraplegia 21 autosomal recessive Mast syndrome protein) (Spastic paraplegia 21 protein)

Gene: SPG21
Organism: Homo sapiens
Interactions: 188
UniProt ID: Q9NZD8

Gene Ontology (top 5):
GO:0005794 - Golgi apparatus
GO:0005829 - cytosol
GO:0010008 - endosome membrane
GO:0030140 - trans-Golgi network transport vesicle
GO:0042609 - CD4 receptor binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1020962

TRAF2
TNF receptor-associated factor 2

5

2

High-throughput

0.722

High

1234828

ATPF2
ATP synthase mitochondrial F1 complex assembly factor 2

6

0

High-throughput

0.712

High

1191413

SPRE2
Sprouty-related, EVH1 domain-containing protein 2

4

1

High-throughput

0.698

High

893498

PRPS1
Ribose-phosphate pyrophosphokinase 1

5

0

High-throughput

0.691

High

1164277

ATRAP
Type-1 angiotensin II receptor-associated protein

5

0

High-throughput

0.689

High

1345767

CUTC
Copper homeostasis protein cutC homolog

5

0

High-throughput

0.687

High

1349082

PRAF1
Prenylated Rab acceptor protein 1

4

0

High-throughput

0.675

High

1023824

TRAF1
TNF receptor-associated factor 1

3

1

High-throughput

0.675

High

1254718

DTX3L
E3 ubiquitin-protein ligase DTX3L

3

1

High-throughput

0.675

High

1349085

IKZF3
Zinc finger protein Aiolos

3

1

High-throughput

0.675

High

358914

CRYAA
Alpha-crystallin A chain

4

0

High-throughput

0.668

High

380874

S100B
Protein S100-B

4

0

High-throughput

0.668

High

1218594

NXP20
Protein NOXP20

4

0

High-throughput

0.668

High

1200360

DTX2
Probable E3 ubiquitin-protein ligase DTX2

5

1

High-throughput

0.658

High

1056407

PLSI
Plastin-1

1

0

High-throughput

0.656

High

845299

RAB7A
Ras-related protein Rab-7a

3

1

Small-scale

0.656

High

1349079

PEF1
Peflin

2

0

High-throughput

0.655

High

1065340

AR6P1
ADP-ribosylation factor-like protein 6-interacting protein 1

3

0

High-throughput

0.646

High

1270151

TFG
Protein TFG

3

0

High-throughput

0.646

High

1349084

GGA2
ADP-ribosylation factor-binding protein GGA2

3

0

High-throughput

0.639

High

1303325

HTF4
Transcription factor 12

2

1

High-throughput

0.628

High

981760

REL
Proto-oncogene c-Rel

3

0

High-throughput

0.622

High

1344706

PYRG2
CTP synthase 2

2

0

High-throughput

0.618

High

1317464

TRI54
Tripartite motif-containing protein 54

3

3

High-throughput

0.616

High

1318682

TRIM9
E3 ubiquitin-protein ligase TRIM9

3

4

High-throughput

0.616

High

1349083

TRIM1
Probable E3 ubiquitin-protein ligase MID2

3

4

High-throughput

0.616

High

1285650

ARL8A
ADP-ribosylation factor-like protein 8A

3

1

High-throughput

0.607

High

337134

HPRT
Hypoxanthine-guanine phosphoribosyltransferase

2

1

High-throughput

0.606

High

444498

K1C19
Keratin, type I cytoskeletal 19

2

3

High-throughput

0.606

High

531521

K1C13
Keratin, type I cytoskeletal 13

2

2

High-throughput

0.606

High

995263

GOGA2
Golgin subfamily A member 2

2

1

High-throughput

0.606

High

1071429

K1H1
Keratin, type I cuticular Ha1

2

3

High-throughput

0.606

High

1191603

SPRE1
Sprouty-related, EVH1 domain-containing protein 1

2

1

High-throughput

0.606

High

1344727

PRDC1
Phosphoribosyltransferase domain-containing protein 1

2

1

High-throughput

0.606

High

1349075

SPG21
Maspardin

1

0

High-throughput

0.589

High

118614

EYA2
Eyes absent homolog 2

2

0

High-throughput

0.580

High

146874

CDKA1
Cyclin-dependent kinase 2-associated protein 1

2

0

High-throughput

0.580

High

157777

GEMI2
Gem-associated protein 2

2

0

High-throughput

0.580

High

200909

CTIF
CBP80/20-dependent translation initiation factor

2

0

High-throughput

0.580

High

206295

RA51C
DNA repair protein RAD51 homolog 3

2

0

High-throughput

0.580

High

215548

CF410
Cilia- and flagella-associated protein 410

2

0

High-throughput

0.580

High

235605

VINEX
Vinexin

2

0

High-throughput

0.580

High

283087

PDE5A
cGMP-specific 3',5'-cyclic phosphodiesterase

2

0

High-throughput

0.580

High

330143

DRC4
Dynein regulatory complex subunit 4

2

0

High-throughput

0.580

High

495629

THIO
Thioredoxin

2

0

High-throughput

0.580

High

555247

NQO2
Ribosyldihydronicotinamide dehydrogenase [quinone]

2

0

High-throughput

0.580

High

641580

PAX6
Paired box protein Pax-6

2

0

High-throughput

0.580

High

656536

PSB4
Proteasome subunit beta type-4

2

0

High-throughput

0.580

High

683011

HNRH1
Heterogeneous nuclear ribonucleoprotein H

2

0

High-throughput

0.580

High

759870

RS19
Small ribosomal subunit protein eS19

2

0

High-throughput

0.580

High

790951

CDN2B
Cyclin-dependent kinase 4 inhibitor B

2

0

High-throughput

0.580

High

884095

GEMI4
Gem-associated protein 4

2

0

High-throughput

0.580

High

983568

DCE2
Glutamate decarboxylase 2

2

0

High-throughput

0.580

High

1066007

IQCB1
IQ calmodulin-binding motif-containing protein 1

2

0

High-throughput

0.580

High

1066114

IF4H
Eukaryotic translation initiation factor 4H

2

0

High-throughput

0.580

High

1191221

DHB13
17-beta-hydroxysteroid dehydrogenase 13

2

0

High-throughput

0.580

High

1192437

S35E3
Solute carrier family 35 member E3

2

0

High-throughput

0.580

High

1204908

TRI50
E3 ubiquitin-protein ligase TRIM50

2

0

High-throughput

0.580

High

1241884

SMIP6
Sperm microtubule inner protein 6

2

0

High-throughput

0.580

High

1251549

CEP76
Centrosomal protein of 76 kDa

2

0

High-throughput

0.580

High

1254517

CCHCR
Coiled-coil alpha-helical rod protein 1

2

0

High-throughput

0.580

High

1260991

SFT2A
Vesicle transport protein SFT2A

2

0

High-throughput

0.580

High

1294985

COG3
Conserved oligomeric Golgi complex subunit 3

2

0

High-throughput

0.580

High

1301565

TRIB3
Tribbles homolog 3

2

0

High-throughput

0.580

High

1304026

PFD5
Prefoldin subunit 5

2

0

High-throughput

0.580

High

1307420

SH3G1
Endophilin-A2

2

0

High-throughput

0.580

High

1309991

VPS25
Vacuolar protein-sorting-associated protein 25

2

0

High-throughput

0.580

High

1331274

FBX44
F-box only protein 44

2

0

High-throughput

0.580

High

1332874

DCTP1
dCTP pyrophosphatase 1

2

0

High-throughput

0.580

High

1342907

ACO13
Acyl-coenzyme A thioesterase 13

2

0

High-throughput

0.580

High

1347591

TXN4B
Thioredoxin-like protein 4B

2

0

High-throughput

0.580

High

1349081

CIDEB
Lipid transferase CIDEB

2

0

High-throughput

0.580

High

1349087

GOT1B
Vesicle transport protein GOT1B

2

0

High-throughput

0.580

High

1349088

CEPT1
Choline/ethanolaminephosphotransferase 1

2

0

High-throughput

0.580

High

580115

K1C15
Keratin, type I cytoskeletal 15

1

2

High-throughput

0.573

High

71013

ZBT42
Zinc finger and BTB domain-containing protein 42

2

2

High-throughput

0.553

High

197841

CRX
Cone-rod homeobox protein

2

1

High-throughput

0.553

High

213175

SNG1
Synaptogyrin-1

2

1

High-throughput

0.553

High

213280

SNG3
Synaptogyrin-3

2

1

High-throughput

0.553

High

517504

PCNA
Proliferating cell nuclear antigen

2

1

High-throughput

0.553

High

982782

PLP2
Proteolipid protein 2

2

3

High-throughput

0.553

High

1049164

TRI14
Tripartite motif-containing protein 14

2

2

High-throughput

0.553

High

1224743

CKLF4
CKLF-like MARVEL transmembrane domain-containing protein 4

2

3

High-throughput

0.553

High

1347864

CKLF6
CKLF-like MARVEL transmembrane domain-containing protein 6

2

3

High-throughput

0.553

High

1349076

ZN581
Zinc finger protein 581

2

1

High-throughput

0.553

High

1346676

ARL8B
ADP-ribosylation factor-like protein 8B

1

1

High-throughput

0.536

High

551299

ITF2
Transcription factor 4

1

1

High-throughput

0.523

High

734793

TRI23
E3 ubiquitin-protein ligase TRIM23

1

1

High-throughput

0.523

High

835542

GSK3A
Glycogen synthase kinase-3 alpha

1

0

Small-scale

0.518

High

1300462

MTMR9
Myotubularin-related protein 9

1

0

High-throughput

0.518

High

147819

G3PT
Glyceraldehyde-3-phosphate dehydrogenase, testis-specific

1

0

High-throughput

0.513

High

523176

SRC
Proto-oncogene tyrosine-protein kinase Src

1

0

High-throughput

0.513

High

837161

KHK
Ketohexokinase

1

0

High-throughput

0.513

High

850598

VAMP7
Vesicle-associated membrane protein 7

1

0

High-throughput

0.513

High

1139780

RRAGB
Ras-related GTP-binding protein B

1

0

High-throughput

0.513

High

1255773

MICA1
[F-actin]-monooxygenase MICAL1

1

0

High-throughput

0.513

High

1300503

VPS35
Vacuolar protein sorting-associated protein 35

1

0

High-throughput

0.513

High

1313274

MIC26
MICOS complex subunit MIC26

1

0

High-throughput

0.513

High

1349078

VPS29
Vacuolar protein sorting-associated protein 29

1

0

High-throughput

0.513

High

348970

RASN
GTPase NRas

1

1

High-throughput

0.479

High

350620

RASK
GTPase KRas

1

1

High-throughput

0.479

High

845775

RAB9A
Ras-related protein Rab-9A

1

1

High-throughput

0.479

High

46510

A0A286YEY3
SLIT-ROBO Rho GTPase activating protein 2B

1

1

High-throughput

0.470

High

360491

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

0

High-throughput

0.460

High

168064

NPC1
NPC intracellular cholesterol transporter 1

1

0

High-throughput

0.458

High

47173

A0A6Q8KRG2
Golgin subfamily A member 2

1

1

High-throughput

0.457

High

483672

SRG2B
SLIT-ROBO Rho GTPase-activating protein 2B

1

1

High-throughput

0.439

High

1121389

AKIR2
Akirin-2

6

0

High-throughput

0.384

High

1293776

REEP6
Receptor expression-enhancing protein 6

4

0

High-throughput

0.364

High

1012368

INCA1
Protein INCA1

3

0

High-throughput

0.352

High

1127597

EFHC2
EF-hand domain-containing family member C2

3

0

High-throughput

0.352

High

1147896

C102B
Coiled-coil domain-containing protein 102B

3

0

High-throughput

0.352

High

1288932

CKLF5
CKLF-like MARVEL transmembrane domain-containing protein 5

3

0

High-throughput

0.352

High

1127189

MTUS2
Microtubule-associated tumor suppressor candidate 2

3

0

High-throughput

0.339

High

1343302

RTN4
Reticulon-4

2

0

High-throughput

0.317

High

135712

NDKM
Nucleoside diphosphate kinase, mitochondrial

2

0

High-throughput

0.316

High

165787

N4BP3
NEDD4-binding protein 3

2

0

High-throughput

0.316

High

168457

SCAM1
Secretory carrier-associated membrane protein 1

2

0

High-throughput

0.316

High

239623

EIF1B
Eukaryotic translation initiation factor 1b

2

0

High-throughput

0.316

High

307744

LERL1
Leptin receptor overlapping transcript-like 1

2

0

High-throughput

0.316

High

316453

MPC2
Mitochondrial pyruvate carrier 2

2

0

High-throughput

0.316

High

361646

APOC1
Apolipoprotein C-I

2

0

High-throughput

0.316

High

439186

SYPH
Synaptophysin

2

0

High-throughput

0.316

High

546111

MYOG
Myogenin

2

0

High-throughput

0.316

High

1349080

ZN629
Zinc finger protein 629

2

0

High-throughput

0.316

High

1349086

COG6
Conserved oligomeric Golgi complex subunit 6

2

0

High-throughput

0.316

High

592825

NR1D1
Nuclear receptor subfamily 1 group D member 1

2

0

High-throughput

0.316

High

638587

RBTN1
Rhombotin-1

2

0

High-throughput

0.316

High

878056

TPD52
Tumor protein D52

2

0

High-throughput

0.316

High

880522

ATP5I
ATP synthase subunit e, mitochondrial

2

0

High-throughput

0.316

High

967006

SATB1
DNA-binding protein SATB1

2

0

High-throughput

0.316

High

993631

TLE5
TLE family member 5

2

0

High-throughput

0.316

High

1069910

PTPA
Serine/threonine-protein phosphatase 2A activator

2

0

High-throughput

0.316

High

1077812

NAB2
NGFI-A-binding protein 2

2

0

High-throughput

0.316

High

1089326

RTL8B
Retrotransposon Gag-like protein 8B

2

0

High-throughput

0.316

High

1102214

VMAC
Vimentin-type intermediate filament-associated coiled-coil protein

2

0

High-throughput

0.316

High

1102719

TXIP1
Translin-associated factor X-interacting protein 1

2

0

High-throughput

0.316

High

1110224

T10IP
Testis-specific protein 10-interacting protein

2

0

High-throughput

0.316

High

1115323

DRC12
Dynein regulatory complex protein 12

2

0

High-throughput

0.316

High

1126988

PPM1J
Protein phosphatase 1J

2

0

High-throughput

0.316

High

1135398

ARM12
Armadillo repeat-containing protein 12

2

0

High-throughput

0.316

High

1156818

SWAP1
ATPase SWSAP1

2

0

High-throughput

0.316

High

1156840

UFSP1
Inactive Ufm1-specific protease 1

2

0

High-throughput

0.316

High

1161234

TT23L
Tetratricopeptide repeat protein 23-like

2

0

High-throughput

0.316

High

1183908

KCTD9
BTB/POZ domain-containing protein KCTD9

2

0

High-throughput

0.316

High

1188259

NUP54
Nucleoporin p54

2

0

High-throughput

0.316

High

1229977

LSME2
Leucine-rich single-pass membrane protein 2

2

0

High-throughput

0.316

High

1230622

NDUF2
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 2

2

0

High-throughput

0.316

High

1235825

CPSF7
Cleavage and polyadenylation specificity factor subunit 7

2

0

High-throughput

0.316

High

1236726

USBP1
Harmonin-binding protein USHBP1

2

0

High-throughput

0.316

High

1237207

CLD22
Claudin-22

2

0

High-throughput

0.316

High

1237947

MB213
Protein mab-21-like 3

2

0

High-throughput

0.316

High

1252522

LNX1
E3 ubiquitin-protein ligase LNX

2

0

High-throughput

0.316

High

1260075

CT55
Cancer/testis antigen 55

2

0

High-throughput

0.316

High

1262146

SMIP5
Sperm-associated microtubule inner protein 5

2

0

High-throughput

0.316

High

1262207

TEKT4
Tektin-4

2

0

High-throughput

0.316

High

1262248

TM239
Transmembrane protein 239

2

0

High-throughput

0.316

High

1264847

BSND
Barttin

2

0

High-throughput

0.316

High

1292773

BORC6
BLOC-1-related complex subunit 6

2

0

High-throughput

0.316

High

1298807

TOX2
TOX high mobility group box family member 2

2

0

High-throughput

0.316

High

1299837

PNMA5
Paraneoplastic antigen-like protein 5

2

0

High-throughput

0.316

High

1300107

FACC1
Flagellum-associated coiled-coil domain-containing protein 1

2

0

High-throughput

0.316

High

1305901

SEPT5
Septin-5

2

0

High-throughput

0.316

High

1312463

TM208
Transmembrane protein 208

2

0

High-throughput

0.316

High

1314657

SSBP4
Single-stranded DNA-binding protein 4

2

0

High-throughput

0.316

High

1317422

PBX4
Pre-B-cell leukemia transcription factor 4

2

0

High-throughput

0.316

High

1326641

NIF3L
NIF3-like protein 1

2

0

High-throughput

0.316

High

1327470

ZMY12
Zinc finger MYND domain-containing protein 12

2

0

High-throughput

0.316

High

1327952

PHS2
Pterin-4-alpha-carbinolamine dehydratase 2

2

0

High-throughput

0.316

High

1332371

ARMC7
Armadillo repeat-containing protein 7

2

0

High-throughput

0.316

High

1333239

NRDE2
Nuclear exosome regulator NRDE2

2

0

High-throughput

0.316

High

1334810

ROP1A
Ropporin-1A

2

0

High-throughput

0.316

High

1334969

GRPE1
GrpE protein homolog 1, mitochondrial

2

0

High-throughput

0.316

High

1343459

RPR1B
Regulation of nuclear pre-mRNA domain-containing protein 1B

2

0

High-throughput

0.316

High

1346718

F86C1
Putative protein FAM86C1P

2

0

High-throughput

0.316

High

1349077

TFP11
Tuftelin-interacting protein 11

2

0

High-throughput

0.316

High

353309

CD4
T-cell surface glycoprotein CD4

1

0

Small-scale

0.288

High

161884

ZN263
Zinc finger protein 263

1

0

High-throughput

0.282

High

674886

AGTR1
Type-1 angiotensin II receptor

1

0

High-throughput

0.282

High

580455

GNAZ
Guanine nucleotide-binding protein G(z) subunit alpha

1

0

High-throughput

0.279

Low

1053300

FA50A
Protein FAM50A

1

0

High-throughput

0.279

Low

1239826

XXLT1
Xyloside xylosyltransferase 1

1

0

High-throughput

0.279

Low

1310779

PXL2A
Peroxiredoxin-like 2A

1

0

High-throughput

0.279

Low

1335058

MYG1
MYG1 exonuclease

1

0

High-throughput

0.268

Low

898085

YPEL3
Protein yippee-like 3

1

0

High-throughput

0.251

Low

1235131

CCD33
Coiled-coil domain-containing protein 33

1

0

High-throughput

0.251

Low

1152149

LTOR1
Ragulator complex protein LAMTOR1

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024