HitPredict

Interactor 1: CFTR (P13569)
Cystic fibrosis transmembrane conductance regulator (CFTR) (ATP-binding cassette sub-family C member 7) (Channel conductance-controlling ATPase) (EC 5.6.1.6) (cAMP-dependent chloride channel)
Gene: CFTR

Interactor 2: K1C12 (Q99456)
Keratin, type I cytoskeletal 12 (Cytokeratin-12) (CK-12) (Keratin-12) (K12)
Gene: KRT12

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	31324722
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1480 Hs			1 494
+	Hs
		529011 CFTR_HUMAN (1-1480): 0: 1031: 100.00		K1C17_HUMAN (119-491): 1.89e-149: 435: 60.05
+	Hs
		359298 CFTR_HUMAN (1-1480): 0: 1031: 100.00		K1C14_HUMAN (94-490): 3.63e-147: 431: 58.44
+	Hs
		528448 CFTR_HUMAN (1-1480): 0: 1031: 100.00		K1C10_HUMAN (120-434): 4.86e-129: 388: 69.21
+	Hs
		444303 CFTR_HUMAN (1-1480): 0: 1031: 100.00		K1C19_HUMAN (112-436): 8.56e-128: 379: 65.23
+	Hs
		528449 CFTR_HUMAN (1-1480): 0: 1031: 100.00		K1C13_HUMAN (117-436): 5.27e-126: 376: 64.38
+	Hs
		444998 CFTR_HUMAN (1-1480): 0: 1031: 100.00		K1C16_HUMAN (121-436): 5.48e-125: 374: 67.09
+	Hs
		529151 CFTR_HUMAN (1-1480): 0: 1031: 100.00		K1H1_HUMAN (119-436): 3.61e-109: 332: 54.40
+	Hs
		280490 CFTR_HUMAN (1-1480): 0: 1031: 100.00		KT33A_HUMAN (119-436): 1.88e-107: 327: 54.40
+	Hs
		529780 CFTR_HUMAN (1-1480): 0: 1031: 100.00		KRT84_HUMAN (20-455): 1.81e-99: 313: 26.77
+	Hs
		529119 CFTR_HUMAN (1-1480): 0: 1031: 100.00		KRT81_HUMAN (10-442): 5.26e-96: 301: 23.96
+	Hs
		528963 CFTR_HUMAN (1-1480): 0: 1031: 100.00		KRT85_HUMAN (16-474): 1.03e-95: 300: 24.51
+	Hs
		213928 CFTR_HUMAN (1-1480): 0: 1031: 100.00		KRT86_HUMAN (10-455): 1.48e-95: 299: 23.49
+	Hs
		318772 CFTR_HUMAN (1-1480): 0: 1031: 100.00		K2C75_HUMAN (9-443): 9e-88: 281: 25.00
+	Hs
		529130 CFTR_HUMAN (1-1480): 0: 1031: 100.00		K2C72_HUMAN (7-443): 4.46e-81: 262: 23.20
+	Hs
		529503 CFTR_HUMAN (1-1480): 0: 1031: 100.00		KRT35_HUMAN (32-440): 5.41e-77: 250: 46.49
+	Hs
		380440 CFTR_HUMAN (1-1480): 0: 1031: 100.00		K2C6B_HUMAN (91-459): 2.81e-74: 246: 25.95
+	Hs
		528450 CFTR_HUMAN (1-1480): 0: 1031: 100.00		K2C5_HUMAN (91-443): 4.05e-74: 246: 27.40
+	Hs
		528760 CFTR_HUMAN (1-1480): 0: 1031: 100.00		K2C6C_HUMAN (91-459): 5.56e-74: 245: 26.49
+	Hs
		359458 CFTR_HUMAN (1-1480): 0: 1031: 100.00		K2C6A_HUMAN (91-459): 4.33e-73: 243: 26.49
+	Hs
		529332 CFTR_HUMAN (1-1480): 0: 1031: 100.00		K2C74_HUMAN (32-444): 1.5e-72: 240: 24.88