HitPredict

Interactor 1: CFTR (P13569)
Cystic fibrosis transmembrane conductance regulator (CFTR) (ATP-binding cassette sub-family C member 7) (Channel conductance-controlling ATPase) (EC 5.6.1.6) (cAMP-dependent chloride channel)
Gene: CFTR

Interactor 2: TRIM5 (Q9C035)
Tripartite motif-containing protein 5 (EC 2.3.2.27) (RING finger protein 88) (RING-type E3 ubiquitin transferase TRIM5)
Gene: TRIM5

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.66	0.60	0.633

Property	Details
Experiments	26618866, 35156780
Identification Methods	affinity chromatography technology, protein complementation assay, ubiquitin reconstruction, anti bait coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	2

Homologous interactions

Color coding for hit scores

	1 1480 Hs			1 493
+	Hs
		528519 CFTR_HUMAN (1-1480): 0: 1031: 100.00		RO52_HUMAN (1-492): 6.35e-136: 402: 39.80
+	Hs
		528467 CFTR_HUMAN (1-1480): 0: 1031: 100.00		TRI27_HUMAN (1-492): 5.51e-121: 365: 29.21