HitPredict

Interactor 1: TAU (P10636)
Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau)
Gene: MAPT

Interactor 2: TP53B (Q12888)
TP53-binding protein 1 (53BP1) (p53-binding protein 1) (p53BP1)
Gene: TP53BP1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.33	0.60	0.445

Property	Details
Experiments	26402096
Identification Methods	anti bait coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0006974 - DNA damage response GO:0051260 - protein homooligomerization
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 758 Hs			1 1972
+	Hs
		1088840 MDC1_HUMAN (31-732): 1.31e-18: 93.5: 10.48		TP53B_HUMAN (1-1972): 0: 762: 100.00
+	Hs
		1088980 CIC_HUMAN (10-717): 9.83e-10: 64.7: 8.46		TP53B_HUMAN (1-1972): 0: 762: 100.00
+	Hs
		1129588 MDC1_HUMAN (31-732): 1.31e-18: 93.5: 10.48		MDC1_HUMAN (24-1848): 6.05e-94: 341: 11.23
+	Hs
		530136 TAU_HUMAN (1-758): 6.41e-90: 300: 100.00		TITIN_HUMAN (5-1527): 2.75e-30: 134: 9.47
+	Hs
		529612 TAU_HUMAN (1-758): 6.41e-90: 300: 100.00		MAP1A_HUMAN (7-1530): 6.97e-21: 103: 8.79
+	Rn
		620003 TAU_RAT (1-758): 3.21e-76: 263: 72.11		MAP1A_RAT (3-1763): 1.47e-23: 111: 9.54
+	Rn
		98693 F1LST4_RAT (1-757): 7.75e-76: 262: 72.21		MAP1A_RAT (3-1763): 1.47e-23: 111: 9.54
+	Hs
		529650 TAU_HUMAN (1-758): 6.41e-90: 300: 100.00		ANK2_HUMAN (82-860): 6.83e-09: 63.6: 13.21
+	Hs
		1403962 MUC4_HUMAN (14-748): 4.59e-20: 98.5: 10.67		MUC4_HUMAN (98-1769): 8.77e-34: 145: 10.53
+	Hs
		1129637 MDC1_HUMAN (31-732): 1.31e-18: 93.5: 10.48		MICA3_HUMAN (254-923): 1.95e-14: 81.7: 14.49
+	Dm
		119660 M9PB30_DROME (3-585): 4.93e-18: 91.6: 9.03		M9PB30_DROME (15-535): 1.82e-11: 72.2: 9.76
+	Mm
		1455913 PCLO_MOUSE (31-654): 3.4e-09: 62.7: 10.40		PCLO_MOUSE (1280-1722): 5.29e-10: 67.2: 9.74