HitPredict

Interactor 1: TAU (P10636)
Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau)
Gene: MAPT

Interactor 2: MARE1 (Q15691)
Microtubule-associated protein RP/EB family member 1 (APC-binding protein EB1) (End-binding protein 1) (EB1)
Gene: MAPRE1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.82	0.60	0.703

Property	Details
Experiments	34079125, 26269332, 36634849, 30668577, 35063084
Identification Methods	proximity labelling technology, affinity chromatography technology, anti tag coimmunoprecipitation, filter binding
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003723 - RNA binding GO:0005829 - cytosol GO:0005874 - microtubule GO:0031110 - regulation of microtubule polymerization or depolymerization GO:0031116 - positive regulation of microtubule polymerization and 1 others more... GO:0046785 - microtubule polymerization
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 758 Hs			1 268
+	Hs
		530593 TAU_HUMAN (1-758): 6.41e-90: 300: 100.00		MARE3_HUMAN (1-268): 1.92e-134: 382: 63.70
+	Hs
		529856 TAU_HUMAN (1-758): 6.41e-90: 300: 100.00		MARE2_HUMAN (1-267): 3.69e-121: 350: 55.16
+	Mm
		530878 TAU_MOUSE (1-758): 8.57e-72: 250: 70.17		MARE2_MOUSE (1-267): 1.05e-118: 344: 55.27
+	Hs
		536343 MTAP2_HUMAN (16-758): 7.48e-30: 129: 23.42		MARE1_HUMAN (1-257): 3.34e-150: 421: 100.00
+	Hs
		536361 MTAP2_HUMAN (16-758): 7.48e-30: 129: 23.42		MARE3_HUMAN (1-268): 1.92e-134: 382: 63.70
+	Hs
		319067 K0754_HUMAN (410-757): 3.14e-12: 72.8: 8.33		MARE1_HUMAN (1-257): 3.34e-150: 421: 100.00
+	Hs
		698392 MAP4_HUMAN (22-721): 3.01e-10: 66.2: 9.24		MARE3_HUMAN (1-268): 1.92e-134: 382: 63.70