HitPredict

Interactor 1: CFTR (P13569)
Cystic fibrosis transmembrane conductance regulator (CFTR) (ATP-binding cassette sub-family C member 7) (Channel conductance-controlling ATPase) (EC 5.6.1.6) (cAMP-dependent chloride channel)
Gene: CFTR

Interactor 2: HYOU1 (Q9Y4L1)
Hypoxia up-regulated protein 1 (150 kDa oxygen-regulated protein) (ORP-150) (170 kDa glucose-regulated protein) (GRP-170) (Heat shock protein family H member 4)
Gene: HYOU1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.60	0.60	0.601

Property	Details
Experiments	26618866, 29924966
Identification Methods	affinity chromatography technology, pull down, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005524 - ATP binding GO:0016020 - membrane GO:0034976 - response to endoplasmic reticulum stress GO:0051087 - protein-folding chaperone binding
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 1480 Hs			1 999
+	Hs
		529494 CFTR_HUMAN (1-1480): 0: 1031: 100.00		HS105_HUMAN (33-960): 0: 812: 24.46
+	Hs
		320805 CFTR_HUMAN (1-1480): 0: 1031: 100.00		HS74L_HUMAN (33-960): 0: 793: 24.57
+	Hs
		528660 CFTR_HUMAN (1-1480): 0: 1031: 100.00		HSP74_HUMAN (33-964): 0: 785: 25.64
+	Hs
		528659 CFTR_HUMAN (1-1480): 0: 1031: 100.00		HS71L_HUMAN (682-814): 9.92e-31: 131: 15.04
+	Hs
		503344 CFTR_HUMAN (1-1480): 0: 1031: 100.00		HSP7C_HUMAN (682-815): 2.07e-30: 130: 16.42
+	Hs
		483745 CFTR_HUMAN (1-1480): 0: 1031: 100.00		HS71A_HUMAN (682-813): 3.35e-30: 129: 16.67
+	Hs
		528829 CFTR_HUMAN (1-1480): 0: 1031: 100.00		HSP72_HUMAN (682-814): 8.57e-30: 128: 16.54
+	Hs
		528491 CFTR_HUMAN (1-1480): 0: 1031: 100.00		HSP76_HUMAN (682-813): 1.1e-27: 121: 19.70
+	Hs
		714340 MRP2_HUMAN (798-1466): 4.31e-56: 217: 15.74		HSP74_HUMAN (33-964): 0: 785: 25.64