HitPredict

Interactor 1: HLAE (P13747)
HLA class I histocompatibility antigen, alpha chain E (MHC class I antigen E) [Cleaved into: Soluble HLA class I histocompatibility antigen, alpha chain E (sHLA-E)]
Gene: HLA-E

Interactor 2: CLC2B (Q92478)
C-type lectin domain family 2 member B (Activation-induced C-type lectin) (C-type lectin superfamily member 2) (IFN-alpha-2b-inducing-related protein 1)
Gene: CLEC2B

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	C1-set~Lectin_C, Lectin_C~MHC_I
Common GO terms	GO:0005886 - plasma membrane GO:0009897 - external side of plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 358 Hs			1 149
+	Hs
		382491 HLAA_HUMAN (1-354): 4.3e-168: 474: 78.81		CLC2B_HUMAN (1-149): 1.2e-43: 142: 100.00
+	Hs
		382559 HLAA_HUMAN (1-354): 4.3e-168: 474: 78.81		CLC4E_HUMAN (28-146): 4.09e-37: 128: 29.63
+	Hs
		59726 HLAA_HUMAN (1-354): 4.3e-168: 474: 78.81		KLRG2_HUMAN (2-146): 5.17e-35: 126: 26.32
+	Hs
		382561 HLAA_HUMAN (1-354): 4.3e-168: 474: 78.81		CLC4A_HUMAN (16-147): 7.74e-35: 122: 23.13
+	Hs
		354302 HLAB_HUMAN (1-354): 2.45e-151: 432: 77.40		NKG2A_HUMAN (8-148): 1.03e-39: 135: 26.75
+	Hs
		570305 HLAG_HUMAN (1-335): 7.83e-150: 427: 76.72		NKG2A_HUMAN (8-148): 1.03e-39: 135: 26.75
+	Hs
		488322 HLAC_HUMAN (1-354): 3.55e-146: 419: 74.65		CLC2B_HUMAN (1-149): 1.2e-43: 142: 100.00
+	Hs
		354602 HLAB_HUMAN (1-354): 2.45e-151: 432: 77.40		CLC4E_HUMAN (28-146): 4.09e-37: 128: 29.63
+	Hs
		533124 HLAE_HUMAN (17-358): 2.88e-145: 416: 100.00		NKG2A_HUMAN (8-148): 1.03e-39: 135: 26.75
+	Hs
		673971 HLAF_HUMAN (1-345): 2.93e-141: 406: 72.75		CLC2B_HUMAN (1-149): 1.2e-43: 142: 100.00
+	Hs
		354435 HLAB_HUMAN (1-354): 2.45e-151: 432: 77.40		KLRD1_HUMAN (25-148): 9.94e-33: 115: 26.72
+	Hs
		488420 HLAC_HUMAN (1-354): 3.55e-146: 419: 74.65		CLC4E_HUMAN (28-146): 4.09e-37: 128: 29.63
+	Hs
		59727 HLAC_HUMAN (1-354): 3.55e-146: 419: 74.65		KLRG2_HUMAN (2-146): 5.17e-35: 126: 26.32
+	Hs
		488269 HLAC_HUMAN (1-354): 3.55e-146: 419: 74.65		CLC4G_HUMAN (24-149): 7.45e-35: 124: 28.78
+	Hs
		488421 HLAC_HUMAN (1-354): 3.55e-146: 419: 74.65		CLC4A_HUMAN (16-147): 7.74e-35: 122: 23.13
+	Hs
		533125 HLAE_HUMAN (17-358): 2.88e-145: 416: 100.00		NKG2C_HUMAN (6-148): 1.44e-33: 119: 23.72
+	Hs
		673995 HLAF_HUMAN (1-345): 2.93e-141: 406: 72.75		CLC2D_HUMAN (3-146): 6.37e-38: 129: 38.07
+	Hs
		488205 HLAC_HUMAN (1-354): 3.55e-146: 419: 74.65		KLRD1_HUMAN (25-148): 9.94e-33: 115: 26.72
+	Hs
		533144 HLAE_HUMAN (17-358): 2.88e-145: 416: 100.00		KLRD1_HUMAN (25-148): 9.94e-33: 115: 26.72
+	Hs
		673960 HLAF_HUMAN (1-345): 2.93e-141: 406: 72.75		CL12B_HUMAN (19-146): 3.08e-35: 124: 31.66