Interactor 1: DNMT1 (P13864)
DNA (cytosine-5)-methyltransferase 1 (Dnmt1) (Met-1) (EC 2.1.1.37) (DNA methyltransferase MmuI) (DNA MTase MmuI) (M.MmuI) (MCMT)
Gene: DNMT1

Interactor 2: UHRF1 (Q8VDF2)
E3 ubiquitin-protein ligase UHRF1 (EC 2.3.2.27) (Nuclear protein 95) (Nuclear zinc finger protein Np95) (RING-type E3 ubiquitin transferase UHRF1) (Ubiquitin-like PHD and RING finger domain-containing protein 1) (mUhrf1) (Ubiquitin-like-containing PHD and RING finger domains protein 1)
Gene: UHRF1

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.88 1.00 0.941

The method score is based on:

Property Details
Experiments 28334952, 30530687, 23754744, 24013172, 30392929, 24782312
Identification Methods pull down, affinity chromatography technology
Interaction Type direct interaction, physical association

The annotation score is based on:

Property Details
Interacting Pfam domains BAH~PHD, DNMT1-RFD~ubiquitin
Common GO terms GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000792 - heterochromatin
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005657 - replication fork
and 3 others

more...

Homologous interactions 11

Homologous interactions

Color coding for hit scores

1 1620
Mm

1 782
+ Hs
+ Hs
+ Xl
+ Hs
+ Hs
+ Zm
+ Hs
+ Hs
+ Hs
+ Dm
+ Dm

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024