Protein: MDM2
E3 ubiquitin-protein ligase Mdm2 (EC 2.3.2.27) (Double minute 2 protein) (Oncoprotein Mdm2) (RING-type E3 ubiquitin transferase Mdm2) (p53-binding protein Mdm2)

Gene: MDM2
Organism: Mus musculus
Interactions: 80
UniProt ID: P23804

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0001568 - blood vessel development
GO:0001974 - blood vessel remodeling
GO:0002027 - regulation of heart rate
GO:0002039 - p53 binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

382448

P53
Cellular tumor antigen p53

34

10

Small-scale

0.994

High

205233

MDM4
Protein Mdm4

7

5

Small-scale

0.958

High

662997

RL11
Large ribosomal subunit protein uL5

5

2

Small-scale

0.912

High

662943

MDM2
E3 ubiquitin-protein ligase Mdm2

2

5

Small-scale

0.778

High

662975

ARF
Tumor suppressor ARF

8

0

Small-scale

0.718

High

662949

RL5
Large ribosomal subunit protein uL18

4

1

Small-scale

0.666

High

662954

UB2D3
Ubiquitin-conjugating enzyme E2 D3

1

14

Small-scale

0.647

High

662955

UB2D1
Ubiquitin-conjugating enzyme E2 D1

1

14

Small-scale

0.647

High

662960

UBC9
SUMO-conjugating enzyme UBC9

1

15

Small-scale

0.647

High

662973

DLG4
Disks large homolog 4

3

3

Small-scale

0.640

High

205199

DAXX
Death domain-associated protein 6

2

2

Small-scale

0.611

High

662958

RL23
Large ribosomal subunit protein uL14

2

1

Small-scale

0.611

High

662963

ELAV1
ELAV-like protein 1

1

0

Small-scale

0.586

High

662992

RASF1
Ras association domain-containing protein 1

1

7

Small-scale

0.586

High

662976

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

2

8

Small-scale

0.584

High

662946

CEBPB
CCAAT/enhancer-binding protein beta

1

2

Small-scale

0.561

High

662950

CCNG1
Cyclin-G1

1

2

Small-scale

0.561

High

662961

PP2AA
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

1

3

Small-scale

0.561

High

662988

SENP2
Sentrin-specific protease 2

1

2

Small-scale

0.561

High

313144

HIPK1
Homeodomain-interacting protein kinase 1

1

8

Small-scale

0.554

High

662965

PDCD1
Programmed cell death protein 1

1

1

Small-scale

0.553

High

662968

RASF5
Ras association domain-containing protein 5

1

6

Small-scale

0.552

High

662944

PAX3
Paired box protein Pax-3

1

0

Small-scale

0.537

High

108976

G3X9P9
SUMO/sentrin specific peptidase 2-like 2A

1

2

Small-scale

0.528

High

663006

DPOE1
DNA polymerase epsilon catalytic subunit A

1

0

Small-scale

0.504

High

74255

EP300
Histone acetyltransferase p300

1

3

Small-scale

0.479

High

98274

ZN431
Zinc finger protein 431

1

1

Small-scale

0.479

High

148650

HDAC1
Histone deacetylase 1

1

3

Small-scale

0.479

High

313397

SP1
Transcription factor Sp1

1

3

Small-scale

0.479

High

518663

EF1A1
Elongation factor 1-alpha 1

1

1

Small-scale

0.479

High

543008

CDK1
Cyclin-dependent kinase 1

1

1

Small-scale

0.479

High

659095

XRCC6
X-ray repair cross-complementing protein 6

1

1

Small-scale

0.479

High

660904

IRF8
Interferon regulatory factor 8

1

2

Small-scale

0.479

High

662945

NECD
Necdin

1

5

Small-scale

0.479

High

662947

TBP
TATA-box-binding protein

1

1

Small-scale

0.479

High

662948

AKT1
RAC-alpha serine/threonine-protein kinase

1

6

Small-scale

0.479

High

662951

HMGA2
High mobility group protein HMGI-C

1

1

Small-scale

0.479

High

662956

WDR5
WD repeat-containing protein 5

1

2

Small-scale

0.479

High

662959

SUMO1
Small ubiquitin-related modifier 1

1

2

Small-scale

0.479

High

662966

UBP39
Ubiquitin carboxyl-terminal hydrolase 39

1

10

Small-scale

0.479

High

662970

IGF1R
Insulin-like growth factor 1 receptor

1

3

Small-scale

0.479

High

662971

EZH2
Histone-lysine N-methyltransferase EZH2

1

5

Small-scale

0.479

High

662972

MRE11
Double-strand break repair protein MRE11

1

2

Small-scale

0.479

High

662974

DLX3
Homeobox protein DLX-3

1

1

Small-scale

0.479

High

662978

WDTC1
WD and tetratricopeptide repeats protein 1

1

2

High-throughput

0.479

High

662979

ZN771
Zinc finger protein 771

1

1

Small-scale

0.479

High

662981

KS6B1
Ribosomal protein S6 kinase beta-1

1

6

Small-scale

0.479

High

662983

CCAR1
Cell division cycle and apoptosis regulator protein 1

1

2

Small-scale

0.479

High

662984

TRIB3
Tribbles homolog 3

1

3

Small-scale

0.479

High

662985

ZN768
Zinc finger protein 768

1

1

Small-scale

0.479

High

662986

DLG2
Disks large homolog 2

1

3

Small-scale

0.479

High

662987

ARRB2
Beta-arrestin-2

1

4

Small-scale

0.479

High

662989

CDK9
Cyclin-dependent kinase 9

1

3

Small-scale

0.479

High

662991

ARBK1
Beta-adrenergic receptor kinase 1

1

5

Small-scale

0.479

High

662993

TRI26
Tripartite motif-containing protein 26

1

2

Small-scale

0.479

High

662996

SMUF1
E3 ubiquitin-protein ligase SMURF1

1

4

Small-scale

0.479

High

662998

MTREX
Exosome RNA helicase MTR4

1

2

Small-scale

0.479

High

663000

EID1
EP300-interacting inhibitor of differentiation 1

1

1

Small-scale

0.479

High

663001

P73
Tumor protein p73

1

10

Small-scale

0.479

High

663002

NBN
Nibrin

1

2

Small-scale

0.479

High

663004

GSK3B
Glycogen synthase kinase-3 beta

1

1

Small-scale

0.479

High

663007

FOXO3
Forkhead box protein O3

1

4

Small-scale

0.479

High

607870

TPIS
Triosephosphate isomerase

1

0

Small-scale

0.458

High

662952

MMP14
Matrix metalloproteinase-14

1

0

Small-scale

0.458

High

662957

SMD2
Small nuclear ribonucleoprotein Sm D2

1

0

Small-scale

0.458

High

662964

MCM6
DNA replication licensing factor MCM6

1

0

Small-scale

0.458

High

662967

CWC27
Spliceosome-associated protein CWC27 homolog

1

0

Small-scale

0.458

High

662980

PUM3
Pumilio homolog 3

1

0

Small-scale

0.458

High

662999

ASCC1
Activating signal cointegrator 1 complex subunit 1

1

0

Small-scale

0.458

High

662982

ARRB1
Beta-arrestin-1

1

4

High-throughput

0.457

High

662962

1433T
14-3-3 protein theta

1

11

Small-scale

0.445

High

662969

Q5SV02
DNA repair protein RAD50

1

2

Small-scale

0.437

High

663005

DECR2
Peroxisomal 2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing]

1

1

Small-scale

0.437

High

662953

S12A2
Solute carrier family 12 member 2

1

0

Small-scale

0.249

Low

662977

PARP6
Protein mono-ADP-ribosyltransferase PARP6

1

0

Small-scale

0.249

Low

662990

ERD21
ER lumen protein-retaining receptor 1

1

0

Small-scale

0.249

Low

662994

AT5F1
ATP synthase peripheral stalk subunit b, mitochondrial

1

0

Small-scale

0.249

Low

662995

NHP2
H/ACA ribonucleoprotein complex subunit 2

1

0

Small-scale

0.249

Low

663003

RFC2
Replication factor C subunit 2

1

0

Small-scale

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025