HitPredict

Interactor 1: EDN3 (P14138)
Endothelin-3 (ET-3) (Preproendothelin-3) (PPET3)
Gene: EDN3

Interactor 2: MEGF8 (Q7Z7M0)
Multiple epidermal growth factor-like domains protein 8 (Multiple EGF-like domains protein 8) (Epidermal growth factor-like protein 4) (EGF-like protein 4)
Gene: MEGF8

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0010468 - regulation of gene expression
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 238 Hs			1 2845
+	Hs
		535622 EDN3_HUMAN (1-238): 3.65e-155: 431: 100.00		NOTC1_HUMAN (561-1682): 5.24e-57: 222: 10.49
+	Hs
		535630 EDN3_HUMAN (1-238): 3.65e-155: 431: 100.00		NOTC2_HUMAN (541-1277): 1.19e-24: 116: 11.76
+	Hs
		276919 EDN3_HUMAN (1-238): 3.65e-155: 431: 100.00		ATRN_HUMAN (447-1260): 1.09e-13: 79.8: 12.56
+	Hs
		535636 EDN3_HUMAN (1-238): 3.65e-155: 431: 100.00		LAMB3_HUMAN (1147-1316): 4.36e-12: 74.3: 30.15
+	Hs
		535624 EDN3_HUMAN (1-238): 3.65e-155: 431: 100.00		LAMB2_HUMAN (853-1167): 2.7e-11: 71.8: 16.06
+	Hs
		535627 EDN3_HUMAN (1-238): 3.65e-155: 431: 100.00		PGBM_HUMAN (1127-1262): 7.19e-11: 70.9: 35.29
+	Hs
		172641 EDN3_HUMAN (1-238): 3.65e-155: 431: 100.00		LAMA5_HUMAN (955-1137): 7.42e-09: 64.1: 19.80