Interactor 1: MIF (P14174)
Macrophage migration inhibitory factor (MIF) (EC 5.3.2.1) (Glycosylation-inhibiting factor) (GIF) (L-dopachrome isomerase) (L-dopachrome tautomerase) (EC 5.3.3.12) (Phenylpyruvate tautomerase)
Gene: MIF

Interactor 2: MIF (P14174)
Macrophage migration inhibitory factor (MIF) (EC 5.3.2.1) (Glycosylation-inhibiting factor) (GIF) (L-dopachrome isomerase) (L-dopachrome tautomerase) (EC 5.3.3.12) (Phenylpyruvate tautomerase)
Gene: MIF

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.85 1.00 0.927

The method score is based on:

Property Details
Experiments 25416956, 32296183, 20534506, 31515488, unassigned1304
Identification Methods two hybrid, two hybrid array, nuclear magnetic resonance, x-ray crystallography, two hybrid prey pooling approach, validated two hybrid
Interaction Type direct interaction, physical association

The annotation score is based on:

Property Details
Interacting Pfam domains MIF~MIF
Common GO terms GO:0001516 - prostaglandin biosynthetic process
GO:0001819 - positive regulation of cytokine production
GO:0002020 - protease binding
GO:0002906 - negative regulation of mature B cell apoptotic process
GO:0004167 - dopachrome isomerase activity
and 46 others

more...

Homologous interactions 2

Homologous interactions

Color coding for hit scores

1 115
Hs

1 115
+ Hs
+ At

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024