HitPredict

Interactor 1: IRF2 (P14316)
Interferon regulatory factor 2 (IRF-2)
Gene: IRF2

Interactor 2: I2BP1 (Q8IU81)
Interferon regulatory factor 2-binding protein 1 (IRF-2-binding protein 1) (IRF-2BP1) (Probable E3 ubiquitin-protein ligase IRF2BP1) (EC 2.3.2.27) (Probable RING-type E3 ubiquitin transferase IRF2BP1)
Gene: IRF2BP1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.88	0.60	0.728

Property	Details
Experiments	12799427, 28514442, 30833792, 33961781, 21903422
Identification Methods	two hybrid, affinity chromatography technology, anti tag coimmunoprecipitation, pull down
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006357 - regulation of transcription by RNA polymerase II
Homologous interactions	3

Homologous interactions

Color coding for hit scores

	1 349 Hs			1 584
+	Hs
		962712 IRF9_HUMAN (7-231): 1.48e-73: 234: 27.19		I2BP1_HUMAN (1-584): 0: 879: 100.00
+	Hs
		536533 IRF2_HUMAN (1-349): 0: 511: 100.00		I2BP2_HUMAN (7-263): 1.14e-62: 218: 29.94
+	Hs
		536551 IRF2_HUMAN (1-349): 0: 511: 100.00		I2BPL_HUMAN (2-84): 3.89e-28: 121: 65.48