HitPredict

Interactor 1: CCNB1 (P14635)
G2/mitotic-specific cyclin-B1
Gene: CCNB1

Interactor 2: CDK2 (P24941)
Cyclin-dependent kinase 2 (EC 2.7.11.22) (Cell division protein kinase 2) (p33 protein kinase)
Gene: CDK2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.96	1.00	0.984

Property	Details
Experiments	9891079, 30674583, 20733051, 18471975, 25852190, 26186194, 26496610, 28514442, 33961781, 35271311, 10995390, 7799941, 23602568, 23455922
Identification Methods	affinity chromatography technology, pull down, anti tag coimmunoprecipitation, tandem affinity purification
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	Cyclin_C~Pkinase, Cyclin_N~Pkinase
Common GO terms	GO:0000086 - G2/M transition of mitotic cell cycle GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005813 - centrosome and 2 others more... GO:0005829 - cytosol GO:0051301 - cell division
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 433 Hs			1 298
+	Hs
		538521 CCNB1_HUMAN (1-433): 6.07e-159: 457: 100.00		CDK3_HUMAN (1-294): 1.8e-154: 435: 76.87
+	Hs
		414711 CCNB1_HUMAN (1-433): 6.07e-159: 457: 100.00		CDK1_HUMAN (1-289): 7.44e-144: 408: 66.90
+	Hs
		538522 CCNB1_HUMAN (1-433): 6.07e-159: 457: 100.00		CDK5_HUMAN (1-292): 1.62e-138: 394: 59.39
+	Mm
		509465 CCNB1_MOUSE (1-432): 6.96e-153: 441: 84.26		CDK1_MOUSE (1-289): 8.74e-143: 405: 66.21
+	Hs
		303829 CCNB2_HUMAN (16-430): 8.52e-118: 351: 48.56		CDK2_HUMAN (1-298): 8.79e-167: 466: 100.00
+	Hs
		625350 CCNA1_HUMAN (21-424): 6.91e-117: 351: 27.70		CDK2_HUMAN (1-298): 8.79e-167: 466: 100.00
+	Hs
		538497 CCNB1_HUMAN (1-433): 6.07e-159: 457: 100.00		CDK7_HUMAN (2-298): 9.81e-124: 359: 44.00
+	Mm
		956329 CCNA1_MOUSE (5-418): 5.26e-118: 352: 26.54		CDK2_MOUSE (1-298): 1.06e-157: 445: 85.26
+	Xl
		526765 CCNB1_XENLA (1-430): 1.29e-126: 373: 64.19		CDK1A_XENLA (1-291): 1.26e-143: 407: 67.12
+	At
		621691 CCA24_ARATH (2-423): 1.65e-118: 355: 28.87		CDKA1_ARATH (1-289): 1.02e-144: 410: 68.62
+	Gg
		533892 CCNB2_CHICK (13-430): 9.7e-121: 358: 48.57		CDK1_CHICK (1-291): 1.09e-142: 405: 67.12
+	Hs
		303821 CCNB2_HUMAN (16-430): 8.52e-118: 351: 48.56		CDK1_HUMAN (1-289): 7.44e-144: 408: 66.90
+	Hs
		414855 CCNA1_HUMAN (21-424): 6.91e-117: 351: 27.70		CDK1_HUMAN (1-289): 7.44e-144: 408: 66.90
+	At
		621660 CCA23_ARATH (7-423): 4.19e-115: 346: 28.11		CDKA1_ARATH (1-289): 1.02e-144: 410: 68.62
+	Hs
		303843 CCNB2_HUMAN (16-430): 8.52e-118: 351: 48.56		CDK5_HUMAN (1-292): 1.62e-138: 394: 59.39
+	At
		1103366 CCA24_ARATH (2-423): 1.65e-118: 355: 28.87		CKB12_ARATH (1-291): 3.9e-133: 381: 56.31
+	At
		1227952 CCA24_ARATH (2-423): 1.65e-118: 355: 28.87		CKB21_ARATH (1-294): 1.78e-131: 377: 54.13
+	At
		639373 CCB24_ARATH (7-423): 9.76e-120: 357: 27.59		CKB11_ARATH (1-291): 1.3e-124: 359: 56.03
+	At
		639358 CCA24_ARATH (2-423): 1.65e-118: 355: 28.87		CKB11_ARATH (1-291): 1.3e-124: 359: 56.03
+	Hs
		303844 CCNB2_HUMAN (16-430): 8.52e-118: 351: 48.56		CDK17_HUMAN (1-296): 1.29e-122: 362: 52.53