Protein: EGR2
E3 SUMO-protein ligase EGR2 (EC 2.3.2.-) (AT591) (E3 SUMO-protein transferase ERG2) (Early growth response protein 2) (EGR-2) (Zinc finger protein Krox-20)

Gene: EGR2
Organism: Homo sapiens
Interactions: 162
UniProt ID: P11161

Gene Ontology (top 5):
GO:0000785 - chromatin
GO:0000976 - transcription cis-regulatory region binding
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001228 - DNA-binding transcription activator activity, RNA polymerase II-specific

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

349758

SNAI1
Zinc finger protein SNAI1

3

19

High-throughput

0.861

High

538366

EGR1
Early growth response protein 1

2

19

High-throughput

0.754

High

177430

ZN536
Zinc finger protein 536

1

15

High-throughput

0.618

High

245580

ZEB2
Zinc finger E-box-binding homeobox 2

1

20

High-throughput

0.618

High

277148

ZN217
Zinc finger protein 217

1

15

High-throughput

0.618

High

538365

ZEP1
Zinc finger protein 40

1

17

High-throughput

0.618

High

538369

ZEP2
Transcription factor HIVEP2

1

20

High-throughput

0.618

High

538387

MECOM
Histone-lysine N-methyltransferase MECOM

1

18

High-throughput

0.618

High

538390

EGR3
Early growth response protein 3

1

19

Small-scale

0.618

High

538401

ZFHX3
Zinc finger homeobox protein 3

1

10

High-throughput

0.618

High

538416

ZN746
Zinc finger protein 746

1

19

High-throughput

0.618

High

538428

ZFHX4
Zinc finger homeobox protein 4

1

17

High-throughput

0.618

High

538446

RREB1
Ras-responsive element-binding protein 1

1

19

High-throughput

0.618

High

538457

ZN521
Zinc finger protein 521

1

9

High-throughput

0.618

High

538459

TREF1
Transcriptional-regulating factor 1

1

4

High-throughput

0.618

High

538466

BC11B
B-cell lymphoma/leukemia 11B

1

20

High-throughput

0.618

High

538468

BC11A
BCL11 transcription factor A

1

19

High-throughput

0.618

High

538471

ZN644
Zinc finger protein 644

1

18

High-throughput

0.618

High

538475

PRD16
Histone-lysine N-methyltransferase PRDM16

1

18

High-throughput

0.618

High

538495

ZN148
Zinc finger protein 148

1

20

High-throughput

0.618

High

538496

ZN281
Zinc finger protein 281

1

18

High-throughput

0.618

High

538399

NAB2
NGFI-A-binding protein 2

2

6

Small-scale

0.595

High

131693

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

1

3

Small-scale

0.573

High

538375

HCFC1
Host cell factor 1

1

2

Small-scale

0.541

High

538436

RB15B
Putative RNA-binding protein 15B

1

1

High-throughput

0.541

High

538384

UBC9
SUMO-conjugating enzyme UBC9

1

3

Small-scale

0.527

High

275610

NDUS2
NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial

1

0

High-throughput

0.518

High

538472

JUPI2
Jupiter microtubule associated homolog 2

1

0

High-throughput

0.518

High

538490

RIMKB
Beta-citrylglutamate synthase B

1

0

High-throughput

0.518

High

538497

MED31
Mediator of RNA polymerase II transcription subunit 31

1

0

High-throughput

0.518

High

340811

NFAC1
Nuclear factor of activated T-cells, cytoplasmic 1

1

8

Small-scale

0.501

High

538478

SRA1
Steroid receptor RNA activator 1

1

1

Small-scale

0.501

High

538487

DNM3L
DNA

1

3

Small-scale

0.501

High

538413

RL7L
Ribosomal protein uL30-like

1

4

High-throughput

0.494

High

538410

MYOME
Myomegalin

1

2

High-throughput

0.481

High

538455

MCRS1
Microspherule protein 1

1

1

High-throughput

0.481

High

138964

BCL9
B-cell CLL/lymphoma 9 protein

1

11

High-throughput

0.479

High

154615

ARI1A
AT-rich interactive domain-containing protein 1A

1

7

High-throughput

0.479

High

161400

KMT2D
Histone-lysine N-methyltransferase 2D

1

9

High-throughput

0.479

High

174302

ZN609
Zinc finger protein 609

1

4

High-throughput

0.479

High

180676

TIF1A
Transcription intermediary factor 1-alpha

1

20

High-throughput

0.479

High

190041

FOXP2
Forkhead box protein P2

1

7

High-throughput

0.479

High

190113

TNC18
Trinucleotide repeat-containing gene 18 protein

1

4

High-throughput

0.479

High

194501

KDM6A
Lysine-specific demethylase 6A

1

5

High-throughput

0.479

High

269086

MITF
Microphthalmia-associated transcription factor

1

2

High-throughput

0.479

High

273971

CREST
Calcium-responsive transactivator

1

20

High-throughput

0.479

High

278218

NCOR1
Nuclear receptor corepressor 1

1

6

High-throughput

0.479

High

344857

WIZ
Protein Wiz

1

19

High-throughput

0.479

High

473748

NFIC
Nuclear factor 1 C-type

1

20

High-throughput

0.479

High

505510

ATX1L
Ataxin-1-like

1

1

High-throughput

0.479

High

538362

CADH1
Cadherin-1

1

4

High-throughput

0.479

High

538363

NR2C1
Nuclear receptor subfamily 2 group C member 1

1

8

High-throughput

0.479

High

538367

ATF3
Cyclic AMP-dependent transcription factor ATF-3

1

8

High-throughput

0.479

High

538368

CADH2
Cadherin-2

1

4

High-throughput

0.479

High

538370

CTNA1
Catenin alpha-1

1

1

High-throughput

0.479

High

538371

CTNB1
Catenin beta-1

1

12

High-throughput

0.479

High

538372

SOX5
Transcription factor SOX-5

1

20

High-throughput

0.479

High

538373

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

8

High-throughput

0.479

High

538374

SMCA2
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2

1

4

High-throughput

0.479

High

538376

HIRA
Protein HIRA

1

2

High-throughput

0.479

High

538377

ATX1
Ataxin-1

1

1

High-throughput

0.479

High

538378

ATN1
Atrophin-1

1

9

High-throughput

0.479

High

538379

HDAC4
Histone deacetylase 4

1

7

High-throughput

0.479

High

538380

RBM11
Splicing regulator RBM11

1

5

High-throughput

0.479

High

538382

LMO4
LIM domain transcription factor LMO4

1

11

High-throughput

0.479

High

538383

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

1

High-throughput

0.479

High

538385

SSBP2
Single-stranded DNA-binding protein 2

1

2

High-throughput

0.479

High

538386

FLI1
Friend leukemia integration 1 transcription factor

1

9

High-throughput

0.479

High

538388

TLE1
Transducin-like enhancer protein 1

1

7

High-throughput

0.479

High

538389

TLE3
Transducin-like enhancer protein 3

1

7

High-throughput

0.479

High

538391

TLE5
TLE family member 5

1

6

High-throughput

0.479

High

538393

EP300
Histone acetyltransferase p300

1

13

High-throughput

0.479

High

538394

NFIA
Nuclear factor 1 A-type

1

19

High-throughput

0.479

High

538395

NAB1
NGFI-A-binding protein 1

1

6

High-throughput

0.479

High

538396

NCOA6
Nuclear receptor coactivator 6

1

5

High-throughput

0.479

High

538397

RBBP5
Retinoblastoma-binding protein 5

1

3

High-throughput

0.479

High

538398

NCOA2
Nuclear receptor coactivator 2

1

4

High-throughput

0.479

High

538400

NCOA1
Nuclear receptor coactivator 1

1

3

High-throughput

0.479

High

538403

PCGF3
Polycomb group RING finger protein 3

1

18

High-throughput

0.479

High

538404

ARI4B
AT-rich interactive domain-containing protein 4B

1

6

High-throughput

0.479

High

538406

FILA2
Filaggrin-2

1

9

High-throughput

0.479

High

538407

BCORL
BCL-6 corepressor-like protein 1

1

2

High-throughput

0.479

High

538411

ZMYM4
Zinc finger MYM-type protein 4

1

17

High-throughput

0.479

High

538412

ARID2
AT-rich interactive domain-containing protein 2

1

7

High-throughput

0.479

High

538414

NIPBL
Nipped-B-like protein

1

2

High-throughput

0.479

High

538415

TET2
Methylcytosine dioxygenase TET2

1

3

High-throughput

0.479

High

538417

NFRKB
Nuclear factor related to kappa-B-binding protein

1

6

High-throughput

0.479

High

538418

MDEAS
Mitotic deacetylase-associated SANT domain protein

1

3

High-throughput

0.479

High

538419

SMRD3
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3

1

1

High-throughput

0.479

High

538420

BCOR
BCL-6 corepressor

1

6

High-throughput

0.479

High

538422

UBN2
Ubinuclein-2

1

10

High-throughput

0.479

High

538423

PAXI1
PAX-interacting protein 1

1

5

High-throughput

0.479

High

538424

POGZ
Pogo transposable element with ZNF domain

1

20

High-throughput

0.479

High

538425

EMSY
BRCA2-interacting transcriptional repressor EMSY

1

8

High-throughput

0.479

High

538426

PCGF5
Polycomb group RING finger protein 5

1

7

High-throughput

0.479

High

538429

BCL9L
B-cell CLL/lymphoma 9-like protein

1

8

High-throughput

0.479

High

538431

DTX1
E3 ubiquitin-protein ligase DTX1

1

2

Small-scale

0.479

High

538432

FOXP4
Forkhead box protein P4

1

7

High-throughput

0.479

High

538433

MGAP
MAX gene-associated protein

1

3

High-throughput

0.479

High

538434

HOMEZ
Homeobox and leucine zipper protein Homez

1

6

High-throughput

0.479

High

538437

KMT2C
Histone-lysine N-methyltransferase 2C

1

12

High-throughput

0.479

High

538438

ZMIZ2
Zinc finger MIZ domain-containing protein 2

1

2

High-throughput

0.479

High

538439

ARI1B
AT-rich interactive domain-containing protein 1B

1

11

High-throughput

0.479

High

538440

TET1
Methylcytosine dioxygenase TET1

1

3

High-throughput

0.479

High

538442

MORC4
MORC family CW-type zinc finger protein 4

1

1

High-throughput

0.479

High

538443

PHF10
PHD finger protein 10

1

9

High-throughput

0.479

High

538445

MAML1
Mastermind-like protein 1

1

6

High-throughput

0.479

High

538447

DPF1
Zinc finger protein neuro-d4

1

11

High-throughput

0.479

High

538448

REQU
Zinc finger protein ubi-d4

1

20

High-throughput

0.479

High

538449

CBP
CREB-binding protein

1

20

High-throughput

0.479

High

538450

KAT2B
Histone acetyltransferase KAT2B

1

12

High-throughput

0.479

High

538451

SMRC1
SWI/SNF complex subunit SMARCC1

1

4

High-throughput

0.479

High

538452

ISL2
Insulin gene enhancer protein ISL-2

1

10

High-throughput

0.479

High

538453

PF21A
PHD finger protein 21A

1

20

High-throughput

0.479

High

538454

ZBTB9
Zinc finger and BTB domain-containing protein 9

1

20

High-throughput

0.479

High

538456

ZN462
Zinc finger protein 462

1

12

High-throughput

0.479

High

538458

EP400
E1A-binding protein p400

1

9

High-throughput

0.479

High

538460

PHF12
PHD finger protein 12

1

20

High-throughput

0.479

High

538461

ARI3A
AT-rich interactive domain-containing protein 3A

1

6

High-throughput

0.479

High

538463

PCGF1
Polycomb group RING finger protein 1

1

18

High-throughput

0.479

High

538465

PCGF6
Polycomb group RING finger protein 6

1

7

High-throughput

0.479

High

538470

FOXP1
Forkhead box protein P1

1

5

High-throughput

0.479

High

538479

BRD7
Bromodomain-containing protein 7

1

11

High-throughput

0.479

High

538480

TF7L2
Transcription factor 7-like 2

1

19

High-throughput

0.479

High

538481

BICRA
BRD4-interacting chromatin-remodeling complex-associated protein

1

8

High-throughput

0.479

High

538482

BAHC1
BAH and coiled-coil domain-containing protein 1

1

2

High-throughput

0.479

High

538483

CHD7
Chromodomain-helicase-DNA-binding protein 7

1

4

High-throughput

0.479

High

538484

RERE
Arginine-glutamic acid dipeptide repeats protein

1

5

High-throughput

0.479

High

538485

TRPS1
Zinc finger transcription factor Trps1

1

2

High-throughput

0.479

High

538486

SIX4
Homeobox protein SIX4

1

3

High-throughput

0.479

High

538488

ZN608
Zinc finger protein 608

1

2

High-throughput

0.479

High

538489

INO80
Chromatin-remodeling ATPase INO80

1

5

High-throughput

0.479

High

538491

PRR12
Proline-rich protein 12

1

8

High-throughput

0.479

High

538492

AKP8L
A-kinase anchor protein 8-like

1

1

High-throughput

0.479

High

538493

TRI33
E3 ubiquitin-protein ligase TRIM33

1

20

High-throughput

0.479

High

538494

HDAC5
Histone deacetylase 5

1

6

High-throughput

0.479

High

538498

ARIP4
Helicase ARIP4

1

10

High-throughput

0.479

High

538499

NCOR2
Nuclear receptor corepressor 2

1

3

High-throughput

0.479

High

538500

NCOA3
Nuclear receptor coactivator 3

1

5

High-throughput

0.479

High

538381

DCAF7
DDB1- and CUL4-associated factor 7

1

0

High-throughput

0.458

High

538405

BCL7A
B-cell CLL/lymphoma 7 protein family member A

1

0

High-throughput

0.458

High

538409

AHDC1
Transcription factor Gibbin

1

0

High-throughput

0.458

High

538427

LDB1
LIM domain-binding protein 1

1

0

High-throughput

0.458

High

538435

IN80E
INO80 complex subunit E

1

0

High-throughput

0.458

High

538441

KDM2B
Lysine-specific demethylase 2B

1

0

High-throughput

0.458

High

538444

GATD1
GATA zinc finger domain-containing protein 1

1

0

High-throughput

0.458

High

538462

PYGO2
Pygopus homolog 2

1

0

High-throughput

0.458

High

538464

PAGR1
PAXIP1-associated glutamate-rich protein 1

1

0

High-throughput

0.458

High

538467

TDIF1
Deoxynucleotidyltransferase terminal-interacting protein 1

1

0

High-throughput

0.458

High

538469

EPC1
Enhancer of polycomb homolog 1

1

0

High-throughput

0.458

High

538473

EAF6
Chromatin modification-related protein MEAF6

1

0

High-throughput

0.458

High

538476

RESF1
Retroelement silencing factor 1

1

0

High-throughput

0.458

High

538392

GOGA2
Golgin subfamily A member 2

1

16

High-throughput

0.439

High

174909

SC16A
Protein transport protein Sec16A

1

2

High-throughput

0.437

High

538402

QSER1
Glutamine and serine-rich protein 1

1

6

High-throughput

0.437

High

538408

PRC2B
Protein PRRC2B

1

9

High-throughput

0.437

High

538421

CO039
Uncharacterized protein C15orf39

1

2

High-throughput

0.437

High

538430

PRSR1
Proline and serine-rich protein 1

1

4

High-throughput

0.437

High

538474

FBRS
Probable fibrosin-1

1

1

High-throughput

0.437

High

538477

FBSL
Fibrosin-1-like protein

1

1

High-throughput

0.437

High

459829

PMGE
Bisphosphoglycerate mutase

1

0

High-throughput

0.282

High

538364

PPA5
Tartrate-resistant acid phosphatase type 5

1

0

High-throughput

0.282

High


Service provided by Combinatics, Japan

Last updated: 11Aug2025